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  • 1
    Language: English
    In: Science (New York, N.Y.), 17 May 2013, Vol.340(6134), pp.879-82
    Description: A negative transcriptional feedback loop generates circadian rhythms in Drosophila. PERIOD (PER) is a critical state-variable in this mechanism, and its abundance is tightly regulated. We found that the Drosophila homolog of ATAXIN-2 (ATX2)--an RNA-binding protein implicated in human neurodegenerative diseases--was required for circadian locomotor behavior. ATX2 was necessary for PER accumulation in circadian pacemaker neurons and thus determined period length of circadian behavior. ATX2 was required for the function of TWENTY-FOUR (TYF), a crucial activator of PER translation. ATX2 formed a complex with TYF and promoted its interaction with polyadenylate-binding protein (PABP). Our work uncovers a role for ATX2 in circadian timing and reveals that this protein functions as an activator of PER translation in circadian neurons.
    Keywords: Circadian Rhythm ; Drosophila Proteins -- Biosynthesis ; Drosophila Melanogaster -- Physiology ; Nerve Tissue Proteins -- Physiology ; Neurons -- Metabolism ; Period Circadian Proteins -- Biosynthesis
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 2
    Language: English
    In: Advanced Materials, Jan 25, 2013, Vol.25(4), p.502(1)
    Description: Byline: Yong Zhang*, Qian Wang ***** No abstract is available for this article. *****
    Keywords: Engineering;
    ISSN: 0935-9648
    E-ISSN: 15214095
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Journal of the American Chemical Society, 24 June 2015, Vol.137(24), pp.7560-3
    Description: Iron porphyrin carbenes (IPCs) are important intermediates in various chemical reactions catalyzed by iron porphyrins and engineered heme proteins, as well as in the metabolism of various xenobiotics by cytochrome P450. However, there are no prior theoretical reports to help understand their formation mechanisms and identify key information governing the binding mode, formation feasibility, and stability/reactivity. A systematic quantum chemical study was performed to investigate the effects of carbene substituent, porphyrin substituent, and axial ligand on IPC formation pathways. Results not only are consistent with available experimental data but also provide a number of unprecedented insights into electronic, steric, and H-bonding effects of various structural factors on IPC formation mechanisms. These results shall facilitate research on IPC and related systems for sustainable chemical catalysis and biocatalysis.
    Keywords: Iron Compounds -- Chemistry ; Metalloporphyrins -- Chemistry ; Methane -- Analogs & Derivatives
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 4
    Language: English
    In: Biophysical Journal, 16 November 2011, Vol.101(10), pp.L47-L49
    Description: Using a reactive molecular dynamics simulation methodology, the free energy barrier for water-mediated proton transport between the two proton gating residues Glu and Glu in the ClC-ec1 antiporter, including the Grotthuss mechanism of proton hopping, was calculated. Three different chloride-binding states, with 1), both the central and internal Cl , 2), the central Cl only, and 3), the internal Cl only, were considered and the coupling to the H transport studied. The results show that both the central and internal Cl are essential for the proton transport from Glu to Glu to have a favorite free energy driving force. The rotation of the Glu side chain was also found to be independent of the internal chloride binding state. These results emphasize the importance of the 2:1 stoichiometry of this well-studied Cl /H antiporter.
    Keywords: Biology
    ISSN: 0006-3495
    E-ISSN: 1542-0086
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  • 5
    Language: English
    In: Neuron, 10 April 2013, Vol.78(1), pp.152-165
    Description: The neuropeptide PDF is crucial for circadian behavior: it keeps circadian neurons synchronized. Here, we identify GW182 as a key regulator of PDF signaling. Indeed, GW182 downregulation results in phenotypes similar to those of and mutants. genetically interacts with and cAMP signaling, which is essential for PDFR function. GW182 mediates miRNA-dependent gene silencing through its interaction with AGO1. Consistently, GW182’s AGO1 interaction domain is required for GW182's circadian function. Moreover, our results indicate that GW182 modulates PDFR signaling by silencing the expression of the cAMP phosphodiesterase DUNCE. Importantly, this repression is under photic control, and GW182 activity level—which is limiting in circadian neurons—influences the responses of the circadian neural network to light. We propose that GW182’s gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts the circadian neural network and its response to environmental inputs. ► GW182 promotes PDFR signaling and is thus critical for circadian behavior ► GW182 gene silencing activity is limiting and determines PDFR signaling levels ► GW182 inhibits the expression of DNC, a negative regulator of PDFR signaling ► GW182 influences the response of the circadian neural network to light input The neuropeptide PDF controls circadian behavior in Drosophila. Zhang and Emery report that GW182—required for miRNA-mediated silencing—modulates PDF signaling by inhibiting . Light controls this repression, suggesting that it may contribute to plasticity of circadian behavior.
    Keywords: Biology ; Anatomy & Physiology
    ISSN: 0896-6273
    E-ISSN: 1097-4199
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  • 6
    In: Nature, 2011, Vol.479(7371), p.80
    Description: Unidentified infrared emission bands at wavelengths of 3-20 micrometres are widely observed in a range of environments in our Galaxy and in others (1). Some features have been identified as the stretching and bending modes of aromatic compounds (2,3), and are commonly attributed to polycyclic aromatic hydrocarbon molecules (4,5). The central argument supporting this attribution is that single-photon excitation of the molecule can account for the unidentified infrared emission features observed in 'cirrus' clouds in the diffuse interstellar medium (6). Of the more than (160) molecules identified in the circumstellar and interstellar environments, however, not one is a polycyclic aromatic hydrocarbon molecule. The detections of discrete and broad aliphatic spectral features suggest that the carrier of the unidentified infrared emission features cannot be a pure aromatic compound. Here we report an analysis of archival spectroscopic observations and demonstrate that the data are most consistent with the carriers being amorphous organic solids with a mixed aromatic-aliphatic structure. This structure is similar to that of the organic materials found in meteorites, as would be expected if the Solar System had inherited these organic materials from interstellar sources.
    Keywords: Polycyclic Aromatic Hydrocarbons -- Health Aspects ; Polycyclic Aromatic Hydrocarbons -- Environmental Aspects ; Polycyclic Aromatic Hydrocarbons -- Research;
    ISSN: 0028-0836
    E-ISSN: 14764687
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  • 7
    Language: English
    In: Journal of the American Chemical Society, May 19, 2010, Vol.132(19), p.6719-6727
    Description: A new model for alkyne inhibition of the [Fe.sub.4][S.sub.4]-cluster-containing protein IspH from Aquifex aeolicus involving [pi] (or [pi]/[sigma]) 'metallacycle' complex formation with the unique fourth Fe in the [Fe.sub.4][S.sub.4] cluster is reported. The new approach could have significant implications for inhibiting other [Fe.sub.4][S.sub.4]-cluster-containing proteins that are of interest as drug and herbicide targets.
    Keywords: Alkynes -- Chemical Properties ; Electron Paramagnetic Resonance Spectroscopy -- Analysis ; Iron Compounds -- Structure ; Iron Compounds -- Chemical Properties ; Organometallic Compounds -- Structure ; Organometallic Compounds -- Chemical Properties ; Phosphates -- Chemical Properties
    ISSN: 0002-7863
    Source: Cengage Learning, Inc.
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  • 8
    Language: English
    In: Journal of Colloid And Interface Science, Feb 15, 2014, Vol.416, p.177(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jcis.2013.11.003 Byline: Yong Zhang, Qian Wang Abstract: Display Omitted Article History: Received 21 August 2013; Accepted 4 November 2013
    Keywords: Pyridine
    ISSN: 0021-9797
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: The Journal of Allergy and Clinical Immunology, 2014, Vol.133(6), pp.1744-1752.e1
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jaci.2013.12.004 Byline: Yong Zhang, Donald Y.M. Leung, Elena Goleva Abstract: Vitamin D is known for its anti-inflammatory effects. Author Affiliation: (a) Department of Pediatrics, National Jewish Health, Denver, Colo (b) Department of Pediatrics, University of Colorado Denver, Aurora, Colo Article History: Received 10 July 2013; Revised 4 December 2013; Accepted 6 December 2013 Article Note: (footnote) Supported by National Institutes of Health grants AI070140, 2R56AI070140, and HL37260 and NIH/NCATS Colorado CTSI grant no. UL1 TR001082. This work was also supported by the Edelstein Family Foundation., Disclosure of potential conflict of interest: Y. Zhang, D. Y. M. Leung, and E. Goleva have received grants from the National Institutes of Health.
    Keywords: Vitamin D ; Glucocorticoids ; Anti-Inflammatory Agents ; Asthma ; Corticosteroid Drugs
    ISSN: 0091-6749
    Source: Cengage Learning, Inc.
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  • 10
    Language: English
    In: Sensors & Actuators: B. Chemical, 2011, Vol.156(2), pp.887-892
    Description: Bi₀.₅Na₀.₅TiO₃–Bi₀.₅K₀.₅TiO₃ (BNT–BKT) powder is synthesized by a metal-organic decomposition method and characterized by field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). A humidity sensor, which is consisted of five pairs of Ag–Pd interdigitated electrodes and an Al₂O₃ ceramic substrate, is fabricated by spin-coating the BNT–BKT powder on the substrate. Good humidity sensing properties such as high response value, short response and recovery times, and small hysteresis are observed in the sensing measurement. The impedance changes more than four orders of magnitude within the whole humidity range from 11% to 95% relative humidity (RH) at 100Hz. The response time and recovery time are about 20 and 60s, respectively. The maximum hysteresis is around 4% RH. The results indicate that BNT–BKT powder is of potential applications for fabricating high performance humidity sensors. ; p. 887-892.
    Keywords: Transmission Electron Microscopy ; Electrodes ; Relative Humidity ; Hysteresis ; Ceramics ; X-Ray Diffraction ; Scanning Electron Microscopy ; Aluminum Oxide ; Impedance
    ISSN: 0925-4005
    E-ISSN: 18733077
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