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  • 1
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 27 August 2013, Vol.110(35), pp.14249-54
    Description: The SNARE complex consists of the three proteins synaptobrevin-2, syntaxin, and synaptosomal-associated protein 25 (SNAP25) and is thought to execute a large conformational change as it drives membrane fusion and exocytosis. The relation between changes in the SNARE complex and fusion pore opening is, however, still unknown. We report here a direct measurement relating a change in the SNARE complex to vesicle fusion on the millisecond time scale. In individual chromaffin cells, we tracked conformational changes in SNAP25 by total internal reflection fluorescence resonance energy transfer (FRET) microscopy while exocytotic catecholamine release from single vesicles was simultaneously recorded using a microfabricated electrochemical detector array. A local rapid and transient FRET change occurred precisely where individual vesicles released catecholamine. To overcome the low time resolution of the imaging frames needed to collect sufficient signal intensity, a method named event correlation microscopy was developed, which revealed that the FRET change was abrupt and preceded the opening of an exocytotic fusion pore by ∼90 ms. The FRET change correlated temporally with the opening of the fusion pore and not with its dilation.
    Keywords: Tir-Fret Imaging ; Electrochemical Imaging ; Image Analysis ; Time Superresolution Microscopy ; Transmitter Release ; Membrane Fusion ; Chromaffin Cells -- Metabolism ; Synaptosomal-Associated Protein 25 -- Metabolism
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 2
    Language: English
    In: Journal of the American College of Cardiology, 20 October 2015, Vol.66(16), pp.C262-C262
    Description: Objectives To retrospective the echocardiographic feature of myocardial dissection after acute myocardial infarction (AMI) Methods The echocardiographic features of five cases with myocardial dissection after AMI were reviewed, and the clinical outcome were followed up Results In 5 cases, 2 were anterior...
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 3
    Language: English
    In: Journal of the American College of Cardiology, 20 October 2015, Vol.66(16), pp.C253-C254
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2015.06.986 Byline: Ying Zhao, Yihua He Author Affiliation: Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University
    Keywords: Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
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  • 4
    Language: English
    In: Journal of Marketing Research, 1 April 2011, Vol.48(2), pp.255-267
    Description: The authors empirically study consumer choice behavior in the wake of a product-harm crisis, which creates consumer uncertainty about product quality. They develop a model that explicitly incorporates the impact of such uncertainty on consumer behavior, assuming that consumers are uncertain about the mean product quality level and learn about product quality through the signals contained in use experience and the product-harm crisis and also that consumers are uncertain about the precision of the signals in conveying product quality and update their perception of this precision over time. They estimate this model using a scanner panel data set that includes consumer purchase history before, during, and after a product-harm crisis that affected Kraft Foods Australia's peanut butter division in June 1996. The proposed model fits the data better than the standard consumer learning model, which assumes consumers are uncertain about product quality level but the precision of information in conveying product quality is known. This study also provides insights into consumers' behavioral choice responses to a product-harm crisis. Finally, the authors conduct counterfactual experiments based on the estimation results and provide insights to managers on crisis management.
    Keywords: Business -- Business administration -- Corporate communications ; Business -- Business administration -- Corporate communications ; Business -- Business information -- Consumer research ; Health sciences -- Health care industry -- Health care facilities ; Behavioral sciences -- Anthropology -- Ethnology ; Social sciences -- Communications -- Advertising ; Economics -- Economic disciplines -- Financial economics ; Mathematics -- Pure mathematics -- Algebra ; Behavioral sciences -- Behavioral economics -- Consumer behavior ; Behavioral sciences -- Psychology -- Cognitive psychology
    ISSN: 00222437
    E-ISSN: 15477193
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  • 5
    Language: English
    In: Water Research, 01 November 2012, Vol.46(17), pp.5635-5644
    Description: Shallow lake eutrophication has been an important issue of global water environment. Based on the simulation and field sampling experiments in Baiyangdian Lake, the largest shallow lake in North China, this study proposed a shallow lake remediation regime with (reed) incorporating its opposite effects of nutrient removal and water evapotranspiration on water quality. The results of simulation experiments showed that both total nitrogen (TN) and phosphorus (TP) removal efficiencies increased with the increasing reed coverage. The TN removal efficiencies by reed aboveground uptake and rhizosphere denitrification were 11.2%, 13.8%, 22.6%, 28.4%, and 29.6% for the reed coverage of 20%, 40%, 60%, 80%, and 100%, respectively. Correspondingly, TP removal efficiencies by aboveground reed uptake were 1.4%, 2.5%, 4.4%, 7.4% and 7.9%, respectively. However, the water quality was best when the reed coverage was 60% (72 plants m ). This was due to the fact that the concentration effect of reed evapotranspiration on nutrient increased with reed coverage. When the reed coverage was 100% (120 plants m ), the evapotranspiration was approximately twice that without reeds. The field sampling results showed that the highest aboveground nutrient storages occurred in September. Thus, the proposed remediation regime for Baiyangdian Lake was that the reed coverage should be adjusted to 60%, and the aboveground biomass of reeds should be harvested in each September. With this remediation regime, TN and TP removal in Baiyangdian Lake were 117.8 and 4.0 g m , respectively, and the corresponding removal efficiencies were estimated to be 49% and 8.5% after six years. This study suggests that reed is an effective plant for the remediation of shallow lake eutrophication, and its contrasting effects of nutrient removal and evapotranspiration on water quality should be considered for establishing the remediation regime in the future. Water quality of shallow lakes will be influenced by two opposite effects of reeds. On the one hand, reeds can remove nutrients from water and sediments, which will improve water quality; on the other hand, their evapotranspiration will lead to higher water nutrient concentrations due to the concentration effect. ► Two opposite effects of reeds on water quality were proposed for shallow lake remediation. ► Reed nutrient removal and evapotranspiration increased with its coverage. ► The water quality was best when the reed coverage was 60%. ► The peak reed nutrient storage occurred in September for Baiyangdian Lake. ► The contribution of rhizosphere denitrification to TN removal by reeds was 72%-82%.
    Keywords: Eutrophication ; Nutrient Removal ; Phragmites Australis ; Remediation ; Shallow Lake ; Water Evapotranspiration ; Engineering
    ISSN: 0043-1354
    E-ISSN: 1879-2448
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  • 6
    Language: English
    In: Journal of Colloid And Interface Science, Sept 1, 2013, Vol.405, p.211(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jcis.2013.05.004 Byline: Ying Zhao, Donglin Zhao, Changlun Chen, Xiangke Wang Abstract: Display Omitted Article History: Received 7 March 2013; Accepted 1 May 2013
    Keywords: Graphene ; Graphite
    ISSN: 0021-9797
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: International Journal of Cardiology, 09 October 2013, Vol.168(4), pp.3560-3563
    Description: Patients with severe, but asymptomatic aortic stenosis (AS) present a difficult clinical challenge. The conventional strategy is ‘wait for symptoms’ approach. However, some observational studies have suggested early aortic valve replacement (AVR) results in better outcome compared to late surgery. There are no randomised controlled trials comparing clinical outcome of early and late AVR. This meta-analysis is to examine the effect of the two approaches on clinical outcome in such patients. We searched the PubMed for published studies on asymptomatic AS and treatment. Four observational studies (N = 976 patients) were suitable for inclusion in the analysis. All four studies provided sufficient details. Using the subgroup of asymptomatic patients who underwent early surgery together or separately from the subgroup who had surgery after developing symptoms resulted in ORs of 0.17 and 0.16 respectively (p 〈 0.00001) in favour of early AVR compared with conservational or late surgery. Meta-analysis of the available observational studies has demonstrated highly significant clinical outcome in favour of early AVR compared with late surgery, suggesting that early surgical approach offers substantial survival benefit for severe asymptomatic AS patients.
    Keywords: Aortic Stenosis ; Asymptomatic ; Valve Replacement ; Medicine
    ISSN: 0167-5273
    E-ISSN: 1874-1754
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  • 8
    Language: English
    In: International Journal of Cardiology, 15 April 2013, Vol.164(3), pp.339-344
    Description: The interventricular septal motion becomes reversed after aortic valve replacement (AVR) for aortic stenosis (AS) despite maintained stroke volume (SV). We hypothesis that left ventricular (LV) lateral wall compensates for such disturbances, in order to secure normal SV. We studied 29 severe AS patients (age 63 ± 11 years, 18 males) with normal ejection fraction (EF) before, 6 months and 12 months after AVR and compared them with 29 age- and gender-matched controls, using speckle tracking echocardiography. In patients, the LVEF and SV remained unchanged throughout. Before AVR, the septal radial motion, septal and lateral strain were reduced (p 〈 0.001). Peak septal and lateral displacements, times from QRS to peak displacement were all not different from controls. Six months after AVR, septal radial motion reversed (p 〈 0.001), lateral strain increased (p 〈 0.05), peak septal displacement reduced (p 〈 0.01) while lateral displacement increased (p 〈 0.05). Time to peak septal displacement delayed (p 〈 0.01) in contrast to lateral displacement which became early (p 〈 0.05), resulting in a significant septal-lateral time delay (p 〈 0.01). The accentuation of LV lateral wall correlated with septal displacement time delay (r = 0.60, p 〈 0.001) and septal–lateral time delay (r = 0.64, p 〈 0.001). SV correlated with lateral displacement (r = 0.39, p 〈 0.05). The systolic strain was correlated with opposite wall displacement (p 〈 0.05 for both). There was no correlation between these measurements before and 12 month after AVR. Accentuated lateral wall displacement compensates for septal dyssynchrony in order to maintain normal LVEF and SV. The continuing recovery of these disturbances 12 months after complete mass regression suggests an ongoing reverse remodeling.
    Keywords: Aortic Valve Replacement ; Displacement ; Dyssynchrony ; Remodeling ; Medicine
    ISSN: 0167-5273
    E-ISSN: 1874-1754
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  • 9
    Language: English
    In: Journal of Language Teaching and Research, Nov, 2013, Vol.4(6), p.1365(6)
    Description: This paper discusses the present problems in college English teachers' professional development from an educational, sociological and management viewpoints. It highlights the necessity of introducing professional learning community (PLC) into teachers' professional development and gives some suggestions at the same time. The main purpose is to promote teachers' collaborative development mode to replace the isolating and competitive one, which puts barriers to college English teachers' professional development. Index Terms--college English teacher, teachers' professional development, professional learning community
    Keywords: Universities And Colleges ; Teachers ; Professional Development
    ISSN: 1798-4769
    E-ISSN: 20530684
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  • 10
    Language: English
    In: PLoS ONE, 2012, Vol.7(2), p.e32152
    Description: Heteroptera, or true bugs, are the largest, morphologically diverse and economically important group of insects with incomplete metamorphosis. However, the phylogenetic relationships within Heteroptera are still in dispute and most of the previous studies were based on morphological characters or with single gene (partial or whole 18S rDNA). Besides, so far, divergence time estimates for Heteroptera totally rely on the fossil record, while no studies have been performed on molecular divergence rates. Here, for the first time, we used maximum parsimony (MP), maximum likelihood (ML) and Bayesian inference (BI) with multiple genes (18S rDNA, 28S rDNA, 16S rDNA and COI) to estimate phylogenetic relationships among the infraorders, and meanwhile, the Penalized Likelihood (r8s) and Bayesian (BEAST) molecular dating methods were employed to estimate divergence time of higher taxa of this suborder. Major results of the present study included: Nepomorpha was placed as the most basal clade in all six trees (MP trees, ML trees and Bayesian trees of nuclear gene data and four-gene combined data, respectively) with full support values. The sister-group relationship of Cimicomorpha and Pentatomomorpha was also strongly supported. Nepomorpha originated in early Triassic and the other six infraorders originated in a very short period of time in middle Triassic. Cimicomorpha and Pentatomomorpha underwent a radiation at family level in Cretaceous, paralleling the proliferation of the flowering plants. Our results indicated that the higher-group radiations within hemimetabolous Heteroptera were simultaneously with those of holometabolous Coleoptera and Diptera which took place in the Triassic. While the aquatic habitat was colonized by Nepomorpha already in the Triassic, the Gerromorpha independently adapted to the semi-aquatic habitat in the Early Jurassic.
    Keywords: Research Article ; Biology ; Genetics And Genomics ; Computational Biology ; Evolutionary Biology
    E-ISSN: 1932-6203
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