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  • 1
    In: Journal of Tissue Engineering and Regenerative Medicine, October 2013, Vol.7(10), pp.757-766
    Description: Liver progenitor cells (LPCs) are a promising source of cells to treat liver disease by cell therapy, due to their capability for self‐replication and bipotentiality. In order to establish useful culture systems of LPCs and apply them to future clinical therapies, it is necessary to understand their interactions with their microenvironment and especially with the extracellular matrix (ECM). There is considerable evidence from studies that matrix proteins affect the activation, expansion, migration and differentiation of LPCs, but the information on the role that specific ECMs play in regulating LPCs is more limited. Nevertheless, current studies suggest that laminin, collagen type III, collagen type IV and hyaluronic acid help to maintain the undifferentiated phenotype of LPCs and promote their proliferation when cultured in media supplemented with growth factors chosen for LPC expansion, whereas collagen type I and fibronectin are generally associated with a differentiated phenotype under the same conditions. Experimental evidence suggests that 61 and 51 integrins as well as CD44 on the surface of LPCs, and their related downstream signals, are important mediators of interactions between LPCs and the ECM. The interactions of LPCs with the ECM form the focus of this review and the contribution of ECM molecules to strategies for optimizing LPC cultures for therapeutic applications is discussed. Copyright © 2012 John Wiley & Sons, Ltd.
    Keywords: Liver Progenitor Cells ; Extracellular Matrix ; Interactions ; Integrins ; Matrix Receptors ; Matrix Turnover
    ISSN: 1932-6254
    E-ISSN: 1932-7005
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  • 2
    Language: English
    In: Tetrahedron: Asymmetry, 2011, Vol.22(14), pp.1530-1535
    Description: A novel water-soluble cationic -monosulfonated chiral diamine ligand diguanidinium was easily prepared from ( , )-DPEN and its rhodium complex and was successfully applied in the asymmetric transfer hydrogenation of prochiral ketones and imines in water by using sodium formate and formic acid as co-hydrogen donors. Various substrates were reduced with high yields and good to excellent enantioselectivities (up to 〉99% ee).
    Keywords: Chemistry
    ISSN: 0957-4166
    E-ISSN: 1362-511X
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  • 3
    Language: English
    In: PLoS ONE, 2012, Vol.7(2), p.e31876
    Description: Schistosomiasis japonica is prevalent in Asian countries and it remains a major public health problem in China. The major endemic foci are the marsh and lake regions of southern China, particularly the Dongting Lake region bordering Hunan and Hubei provinces, and the Poyang Lake region in Jiangxi province. Domestic ruminants, especially bovines, have long been considered to play a major role in the transmission of Schistosoma japonicum to humans. ; A miracidial hatching technique was used to investigate the prevalence of infections in domestic ruminants and field feces collected from two towns located to the south and east of Dongting Lake, Hunan province, between 2005 and 2010. The overall prevalence of infection was not significantly reduced from 4.93% in 2005 to 3.64% in 2008, after which it was maintained at this level. Bovines comprised 23.5–58.2% of the total infected ruminants, while goats comprised 41.8–76.5%. Infection rates in cattle and goats were significantly higher than those found in buffalo in most study years. The prevalence in buffalo younger than three years was significantly higher than that in those aged over three years. All the positive field samples of feces were derived from bovines in Nandashan. In Matang Town, 61.22% of the positive field feces were from bovines, while the rest were from goats. The positive rates for field feces were approximately the same in April and November/October. ; The present study found that bovines and goats are major sources of infection in the Dongting lake region and there was age-related resistance in buffalo. Both bovines and goats should be treated equally when controlling infections in the Dongting lake region. It is essential to conduct an additional mass treatment in late March or early April, in addition to the original treatment scheme.
    Keywords: Research Article ; Biology ; Medicine ; Veterinary Science ; Public Health And Epidemiology ; Infectious Diseases
    E-ISSN: 1932-6203
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  • 4
    Language: English
    In: 2012, Vol.7(9), p.e45302
    Description: A complete texture image retrieval system includes two techniques: texture feature extraction and similarity measurement. Specifically, similarity measurement is a key problem for texture image retrieval study. In this paper, we present an effective similarity measurement formula. The MIT vision texture database, the Brodatz texture database, and the Outex texture database were used to verify the retrieval performance of the proposed similarity measurement method. Dual-tree complex wavelet transform and nonsubsampled contourlet transform were used to extract texture features. Experimental results show that the proposed similarity measurement method achieves better retrieval performance than some existing similarity measurement methods.
    Keywords: Research Article ; Computer Science ; Engineering ; Mathematics ; Computer Science ; Mathematics
    E-ISSN: 1932-6203
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  • 5
    Language: English
    In: PLoS One, San Francisco: Public Library of Science
    Description: Article discussing the bacterial composition of subgingival plaque among diabetic and non-diabetic subjects to determine the effect that diabetes mellitus has on dental health.
    Keywords: Periodontiitis ; Bacteria ; Diabetes ; Pyrosequencing
    ISSN: 19326203
    E-ISSN: 19326203
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  • 6
    Language: English
    In: Journal of Mechanical Science and Technology, 2014, Vol.28(12), pp.4833-4840
    Description: This paper presents dynamic parameters identification analysis of a 3-TPT parallel manipulator with flexible links by means of simulation and experiment. The 3-TPT mechanism is described in detail, and the dynamic equations of the regarded mechanism are derived analytically based on the Newton’s second law. The dynamic simulation model of parallel manipulator with flexible links is built by the integration method of virtual prototyping (VP) and finite element analysis (FEA), which forms the flexible multi-body system of parallel manipulator. Frequency response curves are obtained by applied force on the simulation model, and the stiffness and damping ratio are identified, respectively, from the simulation results. The strategy has been experimentally tested on an actual 3-TPT parallel manipulator. The compared results show that the errors are very small and reasonable scope, so it is feasible for the integration method used as reference and basis for dynamic characteristic. Therefore, the integration simulation method provides a theoretical foundation and reference for dynamic optimal design of parallel manipulator. These analyses and results provide valuable insight into the design and control of the parallel manipulator with flexible links.
    Keywords: Dynamic parameters identification ; Flexible multi-bodies system ; Parallel manipulator ; Virtual prototype (VP) ; Finite element analysis (FEA)
    ISBN: 9783037856666
    ISSN: 1738-494X
    E-ISSN: 1976-3824
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  • 7
    Language: English
    In: Journal of Vibroengineering, 2015, Vol.17(4), p.1660(11)
    Description: In order to obtain the satisfied machining requirements, ball-screw feed drive systems of machine tools need to work accurately and efficiently. A new method which can predict exactly the dynamic performance of feed drive systems by integrating the virtual prototype and finite element is proposed in this paper. The influences of flexible bodies and joint surfaces on dynamic performance were studied based on the finite element theory and dynamic theory. The exciting vibration simulation model can then be formed by using the integration method. The frequency response curves of ball-screw feed drive systems were obtained based on the vibration model, which matched quite well with the experimental results, where the stiffness and damping ratio were also identified respectively. It can be concluded that, therefore, the proposed integration simulation method can offer a theoretical foundation and reference for dynamic optimal design for other products. Keywords: feed drive systems, virtual prototype (VP), finite element (FE), dynamic performance, flexible multi-bodies, joint interface.
    Keywords: Drives (Machinery) – Mechanical Properties ; Finite Element Method – Usage ; Machine Dynamics – Measurement
    ISSN: 1392-8716
    Source: Cengage Learning, Inc.
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  • 8
    Language: English
    In: Advanced Science Letters, 07/01/2011, Vol.4(6), pp.1913-1917
    Description: The Linear Rolling Guide that springs and damping units imitate joints is simulated by finite element methods to analyze accurately the dynamic characteristics of Linear Rolling Guide during the design stage. The proposed method can predict the regular pattern which joint stiffness and joint span affect natural frequency and harmonic response. The research demonstrates that the method predicts well the dynamic characteristics of the Linear Rolling Guide, therefore, the simulation method is feasible by experimental verification, which provides reference for dynamic optimal design Linear Rolling Guide in turn-milling center. References: 6 references open in new window Opening the references page in a new window requires javascript to be enabled in your browser. Articles that cite this article?
    Keywords: Computer Simulation ; Resonant Frequency ; Simulation ; Dynamic Characteristics ; Java (Programming Language) ; Optimization ; Mathematical Analysis ; Damping ; Miscellaneous Sciences (So);
    ISSN: 1936-6612
    E-ISSN: 19367317
    Source: CrossRef
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  • 9
    Language: English
    In: International Journal of Mechanical Sciences, December 2017, Vol.134, pp.357-369
    Description: The normal contact stiffness of mechanical joint has immediate impact on dynamic characteristics and machining precision of machine tools. A fractal contact stiffness model considering the effect of asperity interaction is proposed in this paper. On the basis of elastic theory, the deformation of a given asperity is deduced. The relationship between contact stiffness, normal load and contact area is derived from Hertz contact theory and fractal theory. The effect of asperity interaction on contact stiffness is studied by comparing with fractal model. The fractal smoothness is defined from relation between fractal parameters and surface roughness. It is concluded that with the increase of the fractal dimension  and the decrease of fractal roughness parameter  , the contact stiffness of the joint increases, and the effect of asperity interaction becomes greater. The fractal smoothness also affects the normal contact stiffness and the effect of surface smoothness can be offset by the asperity interaction. Experiment shows that the proposed model is more in line with the actual load-stiffness relationship. The model reveals the factors that affect stiffness of the joint, which can provide a theoretical basis for improving the rigidity and precision of integrated machineries.
    Keywords: Normal Contact Stiffness ; Mechanical Joint ; Asperity Interaction ; Fractal Theory ; Engineering
    ISSN: 0020-7403
    E-ISSN: 1879-2162
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  • 10
    In: Journal of Convergence Information Technology, 1/31/2012, Vol.7(1), pp.19-26
    ISSN: 1975-9320
    E-ISSN: 2233-9299
    Source: CrossRef
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