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RNA polymerases as molecular motors (2009)

Buc, Henri [Sonstige] ; Strick, Terence [Sonstige] ; Neidle, Stephen [Sonstige] ; [weitere]

Cambridge : Royal Society of Chemistry

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UID:

b3kat_BV037195559

Umfang: 1 Online-Ressource (330 p.) , 59 b&w, ill

ISBN: 1847559980 , 9781847559982

Serie: RSC Biomolecular sciences v. 16

Anmerkung: This book, written by expert scientists in the field, analyses how diverse fields of scientific research interact on a specific example - RNA polymerases, The cell can be viewed as a 'collection of protein machines' and understanding these molecular machines requires sophisticated cooperation between cell biologists, geneticists, enzymologists, crystallographers, chemists and physicists. To observe these machines in action, researchers have developed entirely new methodologies for the detection and the nanomanipulation of single molecules. This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerase. The book concentrates on RNA polymerases because they play a central role among all the other machines operating in the cell and are the target of a wide range of regulatory mechanisms. They have also been the subject of spectacular advances in their structural understanding in recent years, as testified by the attribution of the Nobel prize in chemistry in 2006 to Roger Kornberg. The book focuses on two aspects of the transcription cycle that have been more intensively studied thanks to this increased scientific cooperation - the recognition of the promoter by the enzyme, and the achievement of consecutive translocation steps during elongation of the RNA product. Each of these two topics is introduced by an overview, and is then presented by worldwide experts in the field, taking the viewpoint of their speciality. The overview chapters focus on the mechanism-structure interface and the structure-machine interface while the individual chapters within each section concentrate more specifically on particular processes-kinetic analysis, single-molecule spectroscopy, and termination of transcription, amongst others. Specific attention has been paid to the newcomers in the field, with ++ , careful descriptions of new emerging techniques and the constitution of an atlas of three-dimensional pictures of the enzymes involved. For more than thirty years, the study of RNA polymerases has benefited from intense cooperation between the scientific partners involved in the various fields listed above. It is hoped that a collection of essays from outstanding scientists on this subject will catalyse the convergence of scientific efforts in this field, as well as contribute to better teaching at advanced levels in Universities

Sprache: Englisch

Fachgebiete: Biologie

RVK:

WG 1800

Schlagwort(e): DNS-abhängige-RNS-Polymerasen ; Aufsatzsammlung

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Protein-Nucleic Acid Interactions : Structural Biology (2008)

Rice, Phoebe A. [Sonstige] ; Neidle, Stephen [Sonstige] ; Campbell, Simon [Sonstige] ; [weitere]

Cambridge : Royal Society of Chemistry

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UID:

b3kat_BV037195507

Umfang: 1 Online-Ressource (416 p.) , 109 b&w, ill

ISBN: 1847558267 , 9781847558268

Anmerkung: Written by a team of experts, this book bridges the gap between the DNA- and RNA- views of protein-nucleic acid recognition which are often treated as separate fields, The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the , fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between DNA bending and indirect readout. Horvath lays out the fundamentals of protein recognition of single stranded DNA and single stranded RNA, and describes how they apply in a detailed analysis of telomere end binding proteins. Nucleic acids adopt more complex structures - Lilley describes the conformational properties of helical junctions, and how proteins recognize and cleave them. Because RNA readily folds due to the stabilizing role of its 2'-hydroxyl groups, Li discusses how proteins recognize different RNA folds, which include duplex RNA. With the fundamentals laid out, discussion turns to more specialized , examples taken from important aspects of nucleic acid metabolism. Schroeder discusses how proteins chaperone RNA by rearranging its structure into a functional form. Berger and Dong discuss how topoisomerases alter the topology of DNA and relieve the superhelical tension introduced by other processes such as replication and transcription. Dyda and Hickman show how DNA transposes mediate genetic mobility and Van Duyne discusses how site-specific recombinases "cut" and "paste" DNA. Horton presents a comprehensive review of the structural families and chemical mechanisms of DNA nucleases, whereas Li in her discussion of RNA-protein recognition also covers RNA nucleases. Lastly, Ferre-D'Amare shows how proteins recognize and modify RNA transcripts at specific sites. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons

Sprache: Englisch

Fachgebiete: Biologie

RVK:

WD 5100

Schlagwort(e): Proteine ; Nucleinsäuren ; Wechselwirkung ; DNS ; Proteine ; Wechselwirkung ; DNS ; Proteinstoffwechsel ; Aufsatzsammlung

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Metabolomics, Metabonomics and Metabolite Profiling (2007)

Griffiths, William J. [Sonstige] ; Lilley, David M. J. [Sonstige] ; Clore, Marius [Sonstige]

Cambridge : Royal Society of Chemistry

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UID:

b3kat_BV037195448

Umfang: 1 Online-Ressource (336 p.) , 107 b&w, ill

ISBN: 1847558100 , 9781847558107

Anmerkung: In this comprehensive resource the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology, The completion of gene sequencing has resulted in an intensified investigation of the proteome and metabolome. Metabolite profiling methods used for disease diagnosis have been expanded with the advent of new technology and are being applied extensively in the quest for the discovery of new markers for diseases. In this comprehensive resource, the Editor draws together experts from the field and provides an insightful introduction into the technology and methodology. Metabolomics, Metabonomics And Metabolite Profiling covers a broad range of topics including: * Mass spectrometry and NMR in metabolite profiling * Current applications of metabolite profiling for disease diagnosis * Studies of specific metabolite classes * Plant metabolites * Metabolite data mining * Global systems biology This book is a must have, up-to-date, reference which will appeal to academics, students, technicians and professionals working in, or joining this field

Sprache: Englisch

Fachgebiete: Biologie

RVK:

WG 2100

Schlagwort(e): Metabolom ; Chemische Analyse ; Aufsatzsammlung

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Protein folding, misfolding and aggregation : Classical themes and novel approaches (2008)

Muñoz, Victor [Sonstige] 1965- ; Lilley, David M. J. [Sonstige] ; Neidle, Stephen [Sonstige]

Cambridge : Royal Society of Chemistry

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UID:

b3kat_BV037195506

Umfang: 1 Online-Ressource (288 p.) , 44 b&w, ill

ISBN: 1847558283 , 9781847558282

Serie: RSC Biomolecular sciences v. 14

Anmerkung: This unique book covers all the modern approaches and the many advances experienced in the field of protein folding and aggregation during the last 10 years, Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods have evolved to permit resolving fast processes of folding reactions and visualizing single molecules during folding. The findings from these novel experiments and detailed computer simulations have confirmed the main predictions of analytical theory of protein folding. In summary, protein folding research has finally acquired the status of a truly quantitative science, paving the way for more exciting developments in the near future. This unique book covers all the modern approaches and the many advances experienced in the field during the last 10 years. There is also much emphasis on computational methods and studies of protein aggregation which have really flourished in the last decade. It includes chapters in the areas that have witnessed major developments and are written by top experts including:computer simulations of folding, fast folding, single molecule spectroscopy, protein design, aggregation studies (both computational and experimental). Readers will obtain a unique perspective of the problems faced in the biophysical study of protein conformational behaviour in aqueous solution and how these problems are be++ , ing solved with a multidisciplinary approach that combines theory, experiment and computer simulations. Protein Folding, Misfolding and Aggregation Classical Themes and Novel Approaches is essential reading for graduate students actively involved in protein folding research, other scientists interested in the recent progress of the field and instructors revamping the protein folding section of their biochemistry and biophysics courses

Sprache: Englisch

Fachgebiete: Biologie

RVK:

WD 5100

Schlagwort(e): Proteinfaltung ; Aufsatzsammlung

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Gynecologic Cancer (2006)

Eifel, Patricia J. ; Gershenson, David M. ; Kavanagh, John J. ; [weitere]

New York, NY : Springer Science+Business Media, Inc

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UID:

gbv_1646583272

Umfang: Online-Ressource (XIX, 311 p, digital)

ISBN: 9780387287966

Serie: M. D. Anderson Cancer Care Series 5

Anmerkung: Includes bibliographical references and index

Weitere Ausg.: ISBN 9780387287942

Weitere Ausg.: Buchausg. u.d.T. Gynecologic cancer New York. NY : Springer, 2006 ISBN 0387287949

Sprache: Englisch

Fachgebiete: Medizin

RVK:

XH 8203

Schlagwort(e): Frau ; Genitalkrebs ; Frau ; Genitalkrebs ; Aufsatzsammlung

DOI: 10.1007/0-387-28796-5

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URL: Cover

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Semiconductor nanocrystals and silicate nanoparticles (2005)

Peng, Xiaogang ; Mingos, David M. P. 1944- ; Bard, Allan J.

Berlin Heidelberg : Springer

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UID:

gbv_550059342

Umfang: Online-Ressource , Ill., zahlr. graph. Darst.

Ausgabe: Online-Ausg. 2005 Springer eBook Collection. Chemistry and Materials Science

ISBN: 9783540314974

Serie: Structure and bonding 118

Weitere Ausg.: ISBN 9783540278054

Weitere Ausg.: Druckausg. Semiconductor nanocrystals and silicate nanoparticles Berlin : Springer, 2005 ISBN 3540278052

Weitere Ausg.: ISBN 9783540278054

Sprache: Englisch

Schlagwort(e): Halbleiter ; Nanostrukturiertes Material ; Silicate ; Nanopartikel ; Aufsatzsammlung

DOI: 10.1007/b11020

URL: Volltext (lizenzpflichtig)

Mehr zum Autor: Mingos, David M. P. 1944-

Mehr zum Autor: Peng, Xiaogang

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The foundations of medieval English ecclesiastical history : studies presented to David Smith (2005)

Hoskin, Philippa M. [HerausgeberIn] ; Brooke, Christopher Nugent Lawrence [HerausgeberIn] 1927-2015 ; Dobson, R. [HerausgeberIn] ; [weitere]

Suffolk : Boydell & Brewer

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UID:

gbv_1008676462

Umfang: 1 Online-Ressource (xi, 235 pages) , digital, PDF file(s).

ISBN: 9781846153976

Serie: Studies in the history of medieval religion volume 27

Inhalt: The work of historians in providing new editions of primary documents, and other aids to research, has tended to go largely unsung, yet is crucial to scholarship, as providing the very foundations on which further enquiry can be based. The essays in this volume, conversely, celebrate the achievements in this field by a whole generation of medievalists, of whom the honoree, David Smith, is one of the most distinguished. They demonstrate the importance of such editions to a proper understanding and elucidation of a number of problems in medieval ecclesiastical history, ranging from thirteenth-century forgery to diocesan administration, from the church courts to the cloisters, and from the English parish clergy to the papacy. Contributors: CHRISTOPHER BROOKE, C.C. WEBB, JULIA BARROW, NICHOLAS BENNETT, JANET BURTON, CHARLES FONGE, CHRISTOPHER HARPER-BILL, R.H. HELMHOLZ, PHILIPPA HOSKIN, BRIAN KEMP, F. DONALD LOGAN, ALISON MCHARDY

Anmerkung: Title from publisher's bibliographic system (viewed on 30 Oct 2017) , David Smith : the scholar , 'The archivist is not and ought not to be a historian' : David Smith and the Borthwick Institute , Why forge Episcopal acta? : preliminary observations on the forged charters in the English Episcopal Acta series , Pastors and masters : the beneficed clergy of north-east Lincolnshire, 1290-1340 , The convent and the community : cause papers as a source for monastic history , Patriarchy and patrimony : investing in the medieval college , 'Above all these charity' : the career of Walter Suffield, Bishop of Norwich, 1244-57 , The law of charity and the English ecclesiastical courts , Continuing service : the Episcopal households of thirteenth-century Durham , The acta of English rural deans in the later twelfth and early thirteenth centuries , The Court of Arches and the Bishop of Salisbury , Bishops' registers and political history : a neglected resource , The Vatican archives, the papal registers and Great Britain and Ireland : the foundations of historical research , Bibliography of the writings of David Smith.

Weitere Ausg.: ISBN 9781843831693

Weitere Ausg.: Erscheint auch als The foundations of medieval English ecclesiastical history Woodbridge [u.a.] : Boydell & Brewer, 2005 ISBN 1843831694

Weitere Ausg.: Print version ISBN 9781843831693

Sprache: Englisch

Fachgebiete: Geschichte , Allgemeines

RVK:

AK 13000

RVK:

NV 9700

RVK:

NM 9300

Schlagwort(e): England ; Kirchengeschichte 500-1500 ; Aufsatzsammlung ; Festschrift

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Mehr zum Autor: Brooke, Christopher Nugent Lawrence 1927-2015

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