Format:
Online-Ressource
ISSN:
1527-2648
Content:
Abstract: Electrospinning is a versatile technique to generate tissue engineering matrices possessing structural features similar to the extracellular matrix. Biodegradable polylactides are well suited for processing by this technique, but their innate hydrophobicity impairs initial protein adsorption and cell adhesion. In this work, therefore, electrospun poly (l‐lactide‐co‐d,l‐lactide) (70/30) non‐wovens are modified with an ultrathin plasma‐polymerized allylamine (PPAAm) coating. Using scanning electron microsocopy (SEM), it is shown that the fiber structure of the non‐woven is not affected by the plasma treatment. X‐ray photoelectron spectroscopy (XPS) and contact angle measurements of PPAAm‐coated non‐wovens confirm the presence of nitrogen and oxygen‐functional groups in the coating and a hydrophilic nature of the coated non‐woven surface. Cell experiments in vitro demonstrate that the PPAAm‐coated surface promotes occupancy of the non‐woven by human MG‐63 osteoblasts accompanied by improved initial cell spreading and filopodia formation along and between the electrospun polylactide fibers. Overall, plasma‐assisted incorporation of amino groups into electrospun polylactone non‐wovens represents a promising approach to tissue engineering scaffolds with improved cell–material interfaces.
In:
volume:13
In:
number:5
In:
year:2011
In:
pages:B165-B171
In:
extent:7
In:
Advanced engineering materials, Weinheim : Wiley-VCH Verl., [1999]-, 13, Heft 5 (2011), B165-B171 (gesamt 7), 1527-2648
Language:
English
DOI:
10.1002/adem.201080116
URN:
urn:nbn:de:101:1-2023040606290312082905
URL:
https://doi.org/10.1002/adem.201080116
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023040606290312082905
URL:
https://d-nb.info/1285575598/34
URL:
https://doi.org/10.1002/adem.201080116
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