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  • BSZ  (579)
Type of Material
Type of Publication
Consortium
  • BSZ  (579)
  • GBV  (137)
  • 1
    Book
    Book
    Ha er bin : Ha er bin gong ye da xue chu ban she
    UID:
    (DE-627)1645952347
    Format: 245 Seiten , Illustrationen, Fotografien , 26cm
    Edition: Di 1 ban
    Original writing edition: 第1版
    Original writing title: 一个俄罗斯人的哈尔滨情结
    Original writing person/organisation: Коршунов, Сергей
    Original writing publisher: 哈尔滨 : 哈尔滨工业大学出版社
    ISBN: 9787560356181 , 7560356184
    Series Statement: A si tu wen hua xi lie cong shu
    Content: Ben shu nei rong bao kuo:yu ha er bin kai shi jie yuan,Ba fu nu ji ye fu jiao shou,Ao lie ge·Lun zi te ye mu,Ha er bin gong ye da xue di yi ren xiao zhang bi ye yu na ge xue xiao?,Si ta he ye fu jia zu,Ren nan qi ta de e yu ming jiao re ni ya deng
    Language: Chinese , Russian
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  • 2
    UID:
    (DE-627)1791013635
    Format: 1 Online-Ressource (14 p)
    Series Statement: Mathematics Preprint Archive Vol. 2001, Issue 10, pp 281-294
    Content: We find asymptotic formulae for the number of monotone Boolean functions of variables with a most probable number of terms in the minimal disjunctive normal form. It is proven that the distribution of such functions is asymptotically normal if all monotone Boolean functions are equiprobable. The formulae are different depending on whether is even or odd
    Note: Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments October 2001 erstellt
    Language: English
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  • 3
    UID:
    (DE-627)1664962298
    Format: 6
    ISSN: 1091-6490
    Content: The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the developing cerebellum. SHH-MBs can be further subdivided based on molecular and clinical parameters, as well as location because SHH-MBs occur preferentially in the lateral cerebellum (hemispheres). Our analysis of adult patient data suggests that tumors with Smoothened (SMO) mutations form more specifically in the hemispheres than those with Patched 1 (PTCH1) mutations. Using sporadic mouse models of SHH-MB with the two mutations commonly seen in adult MB, constitutive activation of Smo (SmoM2) or loss-of-Ptch1, we found that regardless of timing of induction or type of mutation, tumors developed primarily in the hemispheres, with SmoM2-mutants indeed showing a stronger specificity. We further uncovered that GCPs in the hemispheres are more susceptible to high-level SHH signaling compared with GCPs in the medial cerebellum (vermis), as more SmoM2 or Ptch1-mutant hemisphere cells remain undifferentiated and show increased tumorigenicity when transplanted. Finally, we identified location-specific GCP gene-expression profiles, and found that deletion of the genes most highly expressed in the hemispheres (Nr2f2) or vermis (Engrailed1) showed opposing effects on GCP differentiation. Our studies thus provide insights into intrinsic differences within GCPs that impact on SHH-MB progression.
    Note: Gesehen am 08.05.2019
    In: National Academy of Sciences (Washington, DC), Proceedings of the National Academy of Sciences of the United States of America, Washington, DC : National Acad. of Sciences, 1915, 115(2018), 13, Seite 3392-3397, 1091-6490
    In: volume:115
    In: year:2018
    In: number:13
    In: pages:3392-3397
    In: extent:6
    Language: English
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  • 4
    UID:
    (DE-627)154787063X
    Format: 9
    ISSN: 1432-0533
    Note: Gesehen am 10.10.2016
    In: Acta neuropathologica, Berlin : Springer, 1961, 129(2015), 3, Seite 449-457, 1432-0533
    In: volume:129
    In: year:2015
    In: number:3
    In: pages:449-457
    In: extent:9
    Language: English
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  • 5
    UID:
    (DE-627)1576113213
    Format: 10
    ISSN: 1432-0533
    Content: Posterior fossa ependymomas (EPN_PF) in children comprise two morphologically identical, but biologically distinct tumor entities. Group-A (EPN_PFA) tumors have a poor prognosis and require intensive therapy. In contrast, group-B tumors (EPN_PFB) exhibit excellent prognosis and the current consensus opinion recommends future clinical trials to test the possibility of treatment de-escalation in these patients. Therefore, distinguishing these two tumor subtypes is critical. EPN_PFA and EPN_PFB can be distinguished based on DNA methylation signatures, but these assays are not routinely available. We have previously shown that a subset of poorly prognostic childhood EPN_PF exhibits global reduction in H3K27me3. Therefore, we set out to determine whether a simple immunohistochemical assay for H3K27me3 could be used to segregate EPN_PFA from EPN_PFB tumors. We assembled a cohort of 230 childhood ependymomas and H3K27me3 immunohistochemistry was assessed as positive or negative in a blinded manner. H3K27me3 staining results were compared with DNA methylation-based subgroup information available in 112 samples [EPN_PFA (n = 72) and EPN_PFB tumors (n = 40)]. H3K27me3 staining was globally reduced in EPN_PFA tumors and immunohistochemistry showed 99% sensitivity and 100% specificity in segregating EPN_PFA from EPN_PFB tumors. Moreover, H3K27me3 immunostaining was sufficient to delineate patients with worse prognosis in two independent, non-overlapping cohorts (n = 133 and n = 97). In conclusion, immunohistochemical evaluation of H3K27me3 global reduction is an economic, easily available and readily adaptable method for defining high-risk EPN_PFA from low-risk posterior fossa EPN_PFB tumors to inform prognosis and to enable the design of future clinical trials.
    Note: Gesehen am 06.06.2017
    In: Acta neuropathologica, Berlin : Springer, 1961, 134(2017), 5, Seite 705-714, 1432-0533
    In: volume:134
    In: year:2017
    In: number:5
    In: pages:705-714
    In: extent:10
    Language: English
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  • 6
    UID:
    (DE-627)1582585628
    Format: 11
    ISSN: 1474-5488
    Content: Summary Background Childhood CNS primitive neuro-ectodermal brain tumours (PNETs) are very aggressive brain tumours for which the molecular features and best treatment approaches are unknown. We assessed a large cohort of these rare tumours to identify molecular markers to enhance clinical management of this disease. Methods We obtained 142 primary hemispheric CNS PNET samples from 20 institutions in nine countries and examined transcriptional profiles for a subset of 51 samples and copy number profiles for a subset of 77 samples. We used clustering, gene, and pathway enrichment analyses to identify tumour subgroups and group-specific molecular markers, and applied immunohistochemical and gene-expression analyses to validate and assess the clinical significance of the subgroup markers. Findings We identified three molecular subgroups of CNS PNETs that were distinguished by primitive neural (group 1), oligoneural (group 2), and mesenchymal lineage (group 3) gene-expression signatures with differential expression of cell-lineage markers LIN28 and OLIG2. Patients with group 1 tumours were most often female (male:female ratio 0·61 for group 1 vs 1·25 for group 2 and 1·63 for group 3; p=0·043 [group 1 vs groups 2 and 3]), youngest (median age at diagnosis 2·9 years [95% CI 2·4-5·2] for group 1 vs 7·9 years [6·0-9·7] for group 2 and 5·9 years [4·9-7·8] for group 3; p=0·005), and had poorest survival (median survival 0·8 years [95% CI 0·5-1·2] in group 1, 1·8 years [1·4-2·3] in group 2 and 4·3 years [0·8-7·8] in group 3; p=0·019). Patients with group 3 tumours had the highest incidence of metastases at diagnosis (no distant metastasis:metastasis ratio 0·90 for group 3 vs 2·80 for group 1 and 5·67 for group 2; p=0·037). Interpretation LIN28 and OLIG2 are promising diagnostic and prognostic molecular markers for CNS PNET that warrant further assessment in prospective clinical trials. Funding Canadian Institute of Health Research, Brainchild/SickKids Foundation, and the Samantha Dickson Brain Tumour Trust.
    Note: Gesehen am 05.11.2018
    In: The lancet 〈London〉 / Oncology, London : The Lancet Publ. Group, 2000, 13(2012), 8, Seite 838-848, 1474-5488
    In: volume:13
    In: year:2012
    In: number:8
    In: pages:838-848
    In: extent:11
    Language: English
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  • 7
    UID:
    (DE-627)1532755422
    Format: 15
    ISSN: 1878-3686
    Note: Gesehen am 23.03.2016
    In: Cancer cell, Cambridge, Mass. : Cell Press, 2002, 26(2014), 1, Seite 33-47, 1878-3686
    In: volume:26
    In: year:2014
    In: number:1
    In: pages:33-47
    In: extent:15
    Language: English
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  • 8
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    (DE-627)1652404805
    Format: Online-Ressource (XI, 157 p. 2 illus, digital)
    Edition: 2nd ed. 2013
    ISBN: 9781461471011
    Series Statement: Springer Series in Operations Research and Financial Engineering
    Content: Preface -- Introduction -- Heavy- and long-tailed distributions -- Subexponential distributions -- Densities and local probabilities -- Maximum of random walks -- References -- Index.
    Content: Heavy-tailed probability distributions are an important component in the modeling of many stochastic systems. They are frequently used to accurately model inputs and outputs of computer and data networks and service facilities such as call centers. They are an essential for describing risk processes in finance and also for insurance premia pricing, and such distributions occur naturally in models of epidemiological spread. The class includes distributions with power law tails such as the Pareto, as well as the lognormal and certain Weibull distributions. One of the highlights of this new edition is that it includes problems at the end of each chapter. Chapter 5 is also updated to include interesting applications to queueing theory, risk, and branching processes. New results are presented in a simple, coherent and systematic way. Graduate students as well as modelers in the fields of finance, insurance, network science and environmental studies will find this book to be an essential reference.
    Note: Description based upon print version of record , Preface to the First Edition; Preface; Contents; Notation and Conventions; Chapter 1 Introduction; Chapter 2 Heavy-Tailed and Long-Tailed Distributions; 2.1 Heavy-Tailed Distributions; 2.2 Characterisation of Heavy-Tailed Distributionsin Terms of Generalised Moments; 2.3 Lower Limit for Tails of Convolutions; 2.4 Long-Tailed Functions and Their Properties; 2.5 Long-Tailed Distributions; 2.6 Long-Tailed Distributions and Integrated Tails; 2.7 Convolutions of Long-Tailed Distributions; 2.8 h-Insensitive Distributions; 2.9 Comments; 2.10 Problems; Chapter 3 Subexponential Distributions , 3.1 Subexponential Distributions on the Positive Half-Line3.2 Subexponential Distributions on the Whole Real Line; 3.3 Subexponentiality and Weak Tail-Equivalence; 3.4 The Class S* of Strong Subexponential Distributions; 3.5 Sufficient Conditions for Subexponentiality; 3.6 Conditions for Subexponentiality in Termsof Truncated Exponential Moments; 3.7 S Is a Proper Subset of L; 3.8 Does FS Imply That FIS?; 3.9 Closure Properties of the Class of Subexponential Distributions; 3.10 Kesten's Bound; 3.11 Subexponentiality and Randomly Stopped Sums; 3.12 Comments; 3.13 Problems , Chapter 4 Densities and Local Probabilities4.1 Long Tailed Densities and Their Convolutions; 4.2 Subexponential Densities on the Positive Half-Line; 4.3 Subexponential Densities on the Real Line; 4.4 Sufficient Conditions for Subexponentiality of Densities; 4.5 bold0mu mumu dotted-Long-Tailed Distributions and Their Convolutions; 4.6 bold0mu mumu dotted-Subexponential Distributions; 4.7 bold0mu mumu dotted-Subexponential Distributions on the Real Line; 4.8 Sufficient Conditions for bold0mu mumu dotted-Subexponentiality; 4.9 Local Asymptotics for a Randomly Stopped Sum , 4.10 Local Subexponentiality of Integrated Tails4.11 Comments; 4.12 Problems; Chapter 5 Maximum of Random Walk; 5.1 Asymptotics for the Maximum of a Random Walkwith a Negative Drift; 5.2 Finite Time Horizon Asymptotics; 5.3 Ladder Structure of Maximum of Random Walk; 5.4 Taboo Renewal Measures; 5.5 Asymptotics for the First Ascending Ladder Height; 5.6 Tail of the Maximum Revisited; 5.7 Local Probabilities of the Maximum; 5.8 Density of the Maximum; 5.9 Explicitly Calculable Ascending Ladder Heights; 5.10 Single Server Queueing System; 5.11 Ruin Probabilities in Cramér-Lundberg Model , 5.12 Subcritical Branching Processes5.13 How Do Large Values of M Occur in Standard Cases?; 5.14 Comments; 5.15 Problems; Answers to Problems; References; Index
    Additional Edition: 9781461471004
    Additional Edition: Druckausg. Foss, Sergey An introduction to heavy-tailed and subexponential distributions New York : Springer, 2013 9781461471004
    Additional Edition: 9781489988324
    Language: English
    Subjects: Mathematics
    RVK:
    Keywords: Subexponentielle Verteilung ; Subexponentielle Verteilung
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 9
    UID:
    (DE-627)1575554216
    Format: 13
    ISSN: 1432-0533
    Note: First Online: 03 December 2011 , Gesehen am 28.05.2018
    In: Acta neuropathologica, Berlin : Springer, 1961, 123(2012), 4, Seite 501-513, 1432-0533
    In: volume:123
    In: year:2012
    In: number:4
    In: pages:501-513
    In: extent:13
    Language: English
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  • 10
    UID:
    (DE-627)1656781700
    Format: 1 Online-Ressource (14 Seiten)
    Note: Wissenschaftlicher Aufsatz aus: Acta Neuropathologica Communications, 2 (2014), Nr. 57. pp. 1-14. ISSN 2051-5960
    Language: English
    URL: Volltext  (kostenfrei)
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