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  • BSZ  (7)
Type of Material
Type of Publication
Consortium
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  • 1
    Online Resource
    Online Resource
    Cell-Cycle Mechanisms and Neuronal Cell Death (2005)
    Boston, MA : Springer US
    Details
    UID:
    (DE-627)1647107229
    Format: Online-Ressource (VII, 102 p, digital)
    ISBN: 9780387293905
    Series Statement: Neuroscience Intelligence Unit
    Note: Includes bibliographical references and index
    Additional Edition: 9780306478505
    Additional Edition: Buchausg. u.d.T. 978-0-306-47850-5
    Language: English
    Subjects: Medicine
    RVK:
    YG 1600
    Keywords: Nervenzelle ; Zellzyklus ; Apoptosis ; Aufsatzsammlung
    DOI: 10.1007/0-387-29390-6
    URL: Volltext
    URL: Cover
    URL: Inhaltstext
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  • 2
    Book
    Book
    Carteggio (1753-1786) (2002)
    Napoli : Bibliopolis
    Details
    UID:
    (DE-627)1606575988
    Format: 217 S. , 24 cm
    Series Statement: Istituto Italiano per gli Studi Filosofici 16
    Note: F. Galiani, economist and literary man; L. Mehus (1716 ca.-1802), literary man. - Bound. - Cont. introd. by the editor (pp. 7-29), bibl. refs., notes and index (pp. 207-217). - Letters publ. for the first time
    Language: Italian
    Keywords: Galiani, Ferdinando 1728-1787 ; Mehus, Lorenzo 1716-1802 ; Briefsammlung
    URL: Inhaltsverzeichnis
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  • 3
    Online Resource
    Online Resource
    MGLU Receptors (2017)
    Cham : Springer International Publishing AG
    Details
    UID:
    (DE-627)1797563599
    Format: 1 Online-Ressource (283 pages)
    ISBN: 9783319561707
    Series Statement: The Receptors v.31
    Additional Edition: 9783319561684
    Additional Edition: Erscheint auch als Druck-Ausgabe Ngomba, Richard Teke MGLU Receptors Cham : Springer International Publishing AG,c2017 9783319561684
    Language: English
    URL: lizenzpflichtig
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  • 4
    Online Resource
    Online Resource
    mGLU Receptors (2017)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-627)89707078X
    Format: 1 Online-Ressource (283 pages)
    ISBN: 9783319561707
    Series Statement: The Receptors v.31
    Content: Preface -- Contents -- Chapter 1: mGlu5 Signaling: A Target for Addiction Therapeutics? -- 1.1 Introduction: Pharmacotherapy and Allosteric Modulators -- 1.2 Negative Allosteric Modulators Reduce Drug Reward -- 1.3 mGlu5 Receptors and Synaptic Plasticity -- 1.4 mGlu5 Receptor Expression Changes Across Development of Addiction -- 1.5 Cognitive Capacity Is Positively Correlated with Treatment Outcome for Substance Abuse Disorders -- 1.6 Amnestic Effects of mGlu5 Inactivation -- 1.7 Facilitatory Effects of mGlu5 Activation on Learning, Memory, and Extinction Processes -- 1.8 Conclusion -- References -- Chapter 2: Supraspinal Metabotropic Glutamate Receptors: An Endogenous Substrate for Alleviating Chronic Pain and Related Affective Disorders -- 2.1 Introduction -- 2.2 mGluRs and Pain Processing -- 2.3 Group I mGluRs -- 2.4 Group II mGluRs -- 2.5 Group III mGluRs -- 2.6 Conclusion -- References -- Chapter 3: Metabotropic Glutamate Receptors and Parkinson's Disease: Basic and Preclinical Neuroscience -- 3.1 Parkinson's Disease -- 3.2 Rationale for Targeting mGlu Receptors for Parkinson's Disease -- 3.3 Localization and Function of mGlu Receptors in the Basal Ganglia -- 3.3.1 Group I mGlu Receptors -- 3.3.2 Group II mGlu Receptors -- 3.3.3 Group III mGlu Receptors -- 3.4 Group I mGlu Receptors and Parkinson's Disease -- 3.5 Group II mGlu Receptors and Parkinson's Disease -- 3.6 Group III mGlu Receptors and Parkinson's Disease -- 3.7 Concluding Remarks -- References -- Chapter 4: Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment -- 4.1 Schizophrenia -- 4.2 Metabotropic Glutamate Receptors -- 4.3 Preclinical and Clinical Schizophrenia Assays with mGlu2/3 Receptor Agonists -- 4.4 Environmental Events and mGlu2 Expression -- 4.5 Expression of mGlu2 and 5-HT2A as a GPCR Heteromer in Schizophrenia Treatment -- 4.6 Conclusions
    Content: References -- Chapter 5: mGlu5: A Metabotropic Glutamate Receptor at the Hub of Hippocampal Information Processing, Persistent Synaptic Plasticity, and Long-Term Memory -- 5.1 Introduction -- 5.2 Role of mGlu5 in Persistent Forms of Hippocampal Synaptic Plasticity and Memory -- 5.2.1 Role of mGlu5 in Persistent LTP and LTP-Related Memory -- 5.2.2 Role of mGlu5 in Persistent LTD and LTD-Related Memory -- 5.3 Role of mGlu5 in Hippocampal Information Processing -- 5.3.1 Neuronal Oscillations -- 5.3.2 The Role of mGlu5 in Place Fields -- 5.3.3 The Special Case of the CA3 Region -- 5.4 mGlu5 at the Hub of Hippocampal Function -- References -- Chapter 6: Neuroprotective Properties of Glutamate Metabotropic Glutamate Receptors in Parkinson's Disease and Other Brain Disorders -- 6.1 Introduction -- 6.2 MGluR Localization in the Basal Ganglia Circuitry -- 6.3 Neuroprotective Effects of Group I mGluRs -- 6.4 Neuroprotective Effects of Group II mGluRs in PD -- 6.5 Neuroprotective Effects of Group III mGluRs in PD -- 6.6 Neuroprotective Effects of mGluR-Related Drugs in Other Brain Diseases -- 6.7 Anti-inflammatory Properties of mGluRs: Implications for Neuroprotection -- 6.8 mGluR-Mediated Neuroprotection vs Disease Biomarkers -- References -- Chapter 7: Structure, Dynamics, and Modulation of Metabotropic Glutamate Receptors -- 7.1 Introduction -- 7.2 Functional Organization and Structure of the mGluRs -- 7.3 Crystal Structures and Conformational States of the mGluR -- 7.4 Structural Dynamics of the mGluR ECD During Activation -- 7.5 Dynamics of the mGluR Transmembrane Domain During Activation -- 7.6 Molecular Bases of Ligand Efficacy: Partial Agonism -- 7.7 Allosteric Modulation of the mGluRs -- 7.8 Innovative Ligands Control the Activity of mGluRs with Light -- 7.9 Conclusion and Future Perspectives -- References
    Content: Chapter 8: Metabotropic Glutamate Receptor Function in Thalamocortical Circuitry -- 8.1 Introduction -- 8.2 The Thalamus -- 8.3 Localisation of mGlu Receptors in Thalamocortical Circuitry -- 8.3.1 Group I Receptors -- 8.3.2 Group II Receptors -- 8.3.3 Group III Receptors -- 8.4 mGlu Function in Thalamocortical Circuitry in Health and Disease -- 8.5 Summary -- References -- Chapter 9: Metabotropic Glutamate Receptors in Cancer -- 9.1 Glutamine and Glutamate -- 9.2 mGluRs in Cancer -- 9.3 mGluRs in Primary Brain Tumors -- 9.4 mGluRs in Non-neuronal Cancers -- 9.5 mGluR1 in Melanoma -- 9.6 mGluR1 as a Therapeutic Target in Treating Melanoma -- 9.7 mGluR1 in Brain Metastasis -- 9.8 mGluR1 in Breast Cancer -- 9.9 Conclusions -- References -- Chapter 10: mGlu5 Receptors in Parkinson's Disease and MPTP-Lesioned Monkeys: Behavior and Brain Molecular Correlates -- 10.1 Introduction -- 10.2 Nonhuman Primate Models of L-DOPA-Induced Dyskinesias -- 10.3 Glutamate Neurotransmission in PD and L-DOPA-­Induced Dyskinesias -- 10.4 Ionotropic Glutamate Receptors and L-DOPA-Induced Dyskinesias -- 10.5 Metabotropic Glutamate Receptors and L-DOPA-­Induced Dyskinesias -- 10.6 The Effect of a Chronic Treatment with MPEP on L-DOPA-Induced Dyskinesias and Brain Biochemical Borrelates -- 10.7 Conclusion -- References -- Chapter 11: Is There a Future for mGlu5-Positive Allosteric Modulators in Absence Epilepsy? A Comparison with Ethosuximide -- 11.1 Introduction -- 11.2 The Assumed Working Mechanisms of ETX -- 11.3 New Anti-absence Drugs -- 11.4 Neurochemical Studies -- 11.5 Acute and Subchronic Pharmacological Studies -- 11.6 Local Injection Studies -- 11.7 Comparison Between Ethosuximide and VU0360172 -- 11.8 Discussion -- References -- Chapter 12: Regulation of Hippocampal mGluR-­Dependent Long-Term Depression by GluA2-­Dependent Cofilin-Mediated Actin Remodeling
    Content: 12.1 Introduction -- 12.2 AMPA Glutamate Receptors Mediate Synaptic Plasticity -- 12.3 Rho Signaling Pathways Mediate Spine Plasticity -- 12.4 Cofilin Regulates Spine Actin and Basal Spine Morphology -- 12.5 Cofilin Regulates Both Spine Plasticity and mGluR-LTD -- 12.6 GluA2 Is Necessary for mGluR-LTD and Associated Spine Plasticity -- 12.7 GluA2 Regulation of mGluR-LTD and Spines Is Mediated by Cofilin -- 12.8 GluA2 Regulates Cofilin Through Its N-terminal Interaction with N-cadherin and Subsequent Activation of Rac1 -- 12.9 Concluding Remarks and Future Studies -- References -- Chapter 13: Metabotropic Glutamate Receptors in Amygdala Functions -- 13.1 Introduction -- 13.2 Basic Anatomical Organization of the Amygdala -- 13.3 Historical Overview -- 13.4 Distribution of mGluRs in the Amygdala -- 13.5 Expression of Group I mGluRs in Amygdala -- 13.6 Expression of Group II mGluRs in Amygdala -- 13.7 Expression of Group III mGluRs in Amygdala -- 13.8 Physiology -- 13.9 Relevance of mGluRs for Amygdala-Dependent Emotional Behaviours -- 13.10 Role of mGluRs in Fear Learning -- 13.11 Influence of Group I mGluRs on Fear Learning -- 13.12 Influence of Group II mGluRs on Fear Learning -- 13.13 Influence of Group III mGluRs on Fear Learning -- 13.14 Role of mGluRs in Social Behaviours -- 13.15 Relevance of Amygdala mGluRs for Human Neuropsychiatric Disorders -- 13.16 Anxiety Disorders -- 13.17 Modulation of Anxiety-Like Behaviours by Group I mGluRs -- 13.18 Modulation of Anxiety-Like Behaviours by Group II mGluRs -- 13.19 Modulation of Anxiety-Like Behaviours by Group III mGluRs -- 13.20 Influence of Amygdala mGluRs on Addiction -- 13.21 Role of Amygdala mGluRs on Emotional-Affective Dimensions of Pain -- 13.22 Role of Amygdala mGluRs on Sleep Disorders -- 13.23 Autism Spectrum Disorders -- 13.24 Conclusions -- References -- Index
    Additional Edition: 9783319561684
    Additional Edition: Print version Ngomba, Richard Teke mGLU Receptors Cham : Springer International Publishing,c2017 9783319561684
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 5
    Online Resource
    Online Resource
    mGLU Receptors (2017)
    Cham : Humana Press
    Details
    UID:
    (DE-627)1654865788
    Format: Online-Ressource (X, 282 p. 28 illus., 26 illus. in color, online resource)
    ISBN: 9783319561707
    Series Statement: The Receptors 31
    Content: Metabotropic glutamate receptors (mGluRs) are members of the group C family of G-protein-coupled receptors. Eight different mGlu subtypes have been identified and classified into three groups based on amino acid sequence similarity, agonist pharmacology, and the signal transduction pathways to which they couple. They perform a variety of functions in the central and peripheral nervous systems, being involved in learning, memory, anxiety, and the perception of pain. They are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and cerebral cortex, as well as other parts of the brain and peripheral tissues. This volume comprises the latest contributions of experts in the field on the role of mGlu receptor in health and disease, following the 8th International meeting on these receptors
    Content: mGlu5 Signalling: A Target for Addiction Therapeutics? -- Supraspinal Metabotropic Glutamate Receptors: An Endogenous Substrate for Alleviating Chronic Pain and Related Affective Disorders -- Metabotropic Glutamate Receptors and Parkinson's Disease: Basic and Preclinical Neuroscience -- Metabotropic Glutamate 2 (mGlu2) Receptors and Schizophrenia Treatment -- mGlu5: A Metabotropic Glutamate Receptor at the Hub of Hippocampal Information Processing, Persistent Synaptic Plasticity and Long-Term Memory -- Neuroprotective Properties of Glutamate Metabotropic Glutamate Receptors in Parkinson’s Disease and Other Brain Disorders -- Structure, Dynamics and Modulation of Metabotropic Glutamate Receptors -- Metabotropic Glutamate Receptor Function in Thalamocortical Circuitry -- Metabotropic Glutamate Receptors in Cancer -- mGlu5 Receptors in Parkinson’s Disease and MPTP-Lesioned Monkeys: Behaviour and Brain Molecular Correlates -- Is There a Future for PAMs of Group I mGluR in Absence Epilepsy? -- Regulation of Hippocampal mGluR-Dependent Long-Term Depression by GluA2-Dependent Cofilin-Mediated Actin Remodeling -- Metabotropic Glutamate Receptors in Amygdala Functions
    Additional Edition: 9783319561684
    Additional Edition: Druckausg. 978-3-319-56168-4
    Additional Edition: Printed edition 9783319561684
    Language: English
    DOI: 10.1007/978-3-319-56170-7
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 6
    Article
    Article
    Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats (2013)
    Show associated volumes
    Details
    UID:
    (DE-627)1631544314
    Format: 9
    ISSN: 0028-3908
    In: Neuropharmacology, Orlando, Fla. [u.a.] : Elsevier, 1970, 66(2013), Seite 339-347, 0028-3908
    In: volume:66
    In: year:2013
    In: pages:339-347
    In: extent:9
    Additional Edition: Erscheint auch als Online-Ausgabe Pignatelli, Marco Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats 2013
    Language: English
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  • 7
    Online Resource
    Online Resource
    Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats (2013)
    Show associated volumes
    Details
    UID:
    (DE-627)179715592X
    Format: 9
    ISSN: 1873-7064
    Content: Alterations of the glutamatergic system have been implicated in the pathophysiology and treatment of major depression. In order to investigate the expression and function of mGlu5 receptors in an animal model for treatment-resistant depression we used rats bred for congenital learned helplessness (cLH) and the control strain, bred for resistance against inescapable stress, congenitally. not learned helpless rats (cNLH). Western blot analysis showed an increased expression of mGlu5 (but not mGlu1a) receptors in the hippocampus of cLH rats, as compared with control cNLH rats. We also examined mGlu1/5 receptor signaling by in vivo measurement of DHPG-stimulated polyphosphoinositides hydrolysis. Stimulation of 3H-inositolmonophosphate formation induced by i.c.v. injection of DHPG was enhanced by about 50% in the hippocampus of cLH rats. Correspondingly, DHPG-induced long-term depression (LTD) at Schaffer collateral/CA1 pyramidal cell synapses was amplified in hippocampal slices of cLH rats, whereas LTD induced by low frequency stimulation of the Schaffer collaterals did not change. Moreover, these effects were associated with decreased basal dendritic spine density of CA1 pyramidal cell in cLH rats. These data raise the attractive possibility that changes in the expression and function of mGlu5 receptors in the hippocampus might underlie the changes in synaptic plasticity associated with the depressive-like phenotype of cLH rats. However, chronic treatment of cLH rats with MPEP did not reverse learned helplessness, indicating that the enhanced mGlu5 receptor function is not the only player in the behavioral phenotype of this genetic model of depression. This article is part of a Special Issue entitled ‘Metabotropic Glutamate Receptors’.
    Note: Gesehen am 31.03.2022
    In: Neuropharmacology, Amsterdam [u.a.] : Elsevier Science, 1970, 66(2013), Seite 339-347, 1873-7064
    In: volume:66
    In: year:2013
    In: pages:339-347
    In: extent:9
    Additional Edition: Erscheint auch als Druck-Ausgabe Pignatelli, Marco Enhanced mGlu5-receptor dependent long-term depression at the Schaffer collateral-CA1 synapse of congenitally learned helpless rats 2013
    Language: English
    DOI: 10.1016/j.neuropharm.2012.05.046
    URL: Volltext  (lizenzpflichtig)
    URL: Volltext  (lizenzpflichtig)
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