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  • BSZ  (92)
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  • 1
    UID:
    (DE-627)1109539592
    Format: 112 S. , graph. Darst.
    Note: Heidelberg, Univ., Diss., 1994
    Language: German
    Keywords: Hochschulschrift
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  • 2
    UID:
    (DE-627)1581831846
    Format: 22
    ISSN: 1361-6560
    Content: The purpose of this work was to design and manufacture a 3D range-modulator for scanned particle therapy. The modulator is intended to create a highly conformal dose distribution with only one fixed energy, simultaneously reducing considerably the treatment time. As a proof of concept, a 3D range-modulator was developed for a spherical target volume with a diameter of 5 cm, placed at a depth of 25 cm in a water phantom. It consists of a large number of thin pins with a well-defined shape and different lengths to modulate the necessary shift of the Bragg peak. The 3D range-modulator was manufactured with a rapid prototyping technique. The FLUKA Monte Carlo package was used to simulate the modulating effect of the 3D range-modulator and the resulting dose distribution. For that purpose, a special user routine was implemented to handle its complex geometrical contour. Additionally, FLUKA was extended with the capability of intensity modulated scanning. To validate the simulation results, dose measurements were carried out at the Heidelberg Ion Beam Therapy Center with a 400.41 MeV/u 12 C beam. The high resolution dosimetric measurements show a good agreement between simulated and measured dose distributions. Irradiation of the monoenergetic raster plan took 3 s, which is approximately 20 times shorter than a comparable plan with 16 different energies. The combination of only one energy and a 3D range-modulator leads to a tremendous decrease in irradiation time. ‘Interplay effects’, typical for moving targets and pencil beam scanning, can be immensely reduced or disappear completely, making the delivery of a homogeneous dose to moving targets more reliable. Combining high dose conformity, very good homogeneity and extremely short irradiation times, the 3D range-modulator is considered to become a clinically applicable method for very fast treatment of lung tumours.
    Note: Gesehen am 12.10.2018
    In: Physics in medicine and biology, Bristol : IOP Publ., 1956, 62(2017), 17, Seite 7075-7096, 1361-6560
    In: volume:62
    In: year:2017
    In: number:17
    In: pages:7075-7096
    In: extent:22
    Language: English
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  • 3
    UID:
    (DE-627)158213233X
    Format: 7
    ISSN: 0168-9002
    Content: For the feasibility studies of spatially fractionated hadron therapy prototypes of the equipment for hadron minibeams shaping and monitoring have been designed, built and tested. The collimators design was based on Monte Carlo simulations (Gate v.6.2). Slit and matrix collimators were used for minibeams shaping. Gafchromic films, micropixel detectors Timepix in a hybrid as well as metal mode were tested for measuring hadrons intensity distribution in minibeams. An overall beam profile was measured by the metal microstrip detector. The performance of a mini-beams shaping and monitoring equipment was characterized exploring low energy protons at the KINR Tandem generator as well as high energy carbon and oxygen ion beams at HIT (Heidelberg). The results demonstrate reliable performance of the tested equipment for shaping and imaging hadron mini-beam structures.
    Note: Available online 14 August 2017 , Gesehen am 19.10.2018
    In: Nuclear instruments & methods in physics research / A, Amsterdam : North-Holland Publ. Co., 1984, 872(2017), Seite 119-125, 0168-9002
    In: volume:872
    In: year:2017
    In: pages:119-125
    In: extent:7
    Language: English
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  • 4
    UID:
    (DE-627)1574338838
    Format: 7
    ISSN: 2473-4209
    Content: Purpose To perform dosimetric characterization of a minibeam collimator in both carbon and oxygen ion beams to guide optimal setup geometry and irradiation for future radiobiological studies. Methods Carbon and oxygen minibeams were generated using a prototype tungsten multislit collimator presenting line apertures 700 ?m wide, which are spaced 3500 ?m centre?to?centre distance apart. Several radiation beam spots generated the desired field size of 15 ? 15 mm2 and production of a 50 mm long spread out Bragg peak (SOBP) centered at 80 mm depth in water. Dose evaluations were performed with two different detectors: a PTW microDiamond single crystal diamond detector and radiochromic films (EBT3). Peak?to?valley dose ratio (PVDR) values, output factors (OF), penumbras, and full width at half maximum (FWHM) were measured. Results Measured lateral dose profiles exhibited spatial fractionation of dose at depth in a water phantom in the expected form of peaks and valleys for both carbon and oxygen radiation fields. The diamond detector and radiochromic film provided measurements of PVDR in good agreement. PVDR values at shallow depth were about 60 and decreased to about 10 at 80 mm depth in water. OF in the center of the SOBP was about 0.4; this value is larger than the corresponding one in proton minibeam radiation therapy measured using a comparable collimator due to a reduced lateral scattering for carbon and oxygen minibeams. Conclusions Carbon and oxygen minibeams may be produced by a mechanical collimator. PVDR values and output factors measured in this first study of these minibeam radiation types indicate there is potential for their therapeutic use. Optimization of minibeam collimator design and the number and size of focal spots for irradiation are advocated to improve PDVR values and dose distributions for each specific applied use.
    Note: Gesehen am 09.05.2018
    In: Medical physics, Hoboken, NJ : Wiley, 1974, 44(2017), 8, Seite 4223-4229, 2473-4209
    In: volume:44
    In: year:2017
    In: number:8
    In: pages:4223-4229
    In: extent:7
    Language: English
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  • 5
    UID:
    (DE-627)1662563078
    Format: 15
    ISSN: 1361-6560
    Content: Single-event ion imaging enables the direct reconstruction of the relative stopping power (RSP) information required for ion-beam therapy. Helium ions were recently hypothesized to be the optimal species for such technique. The purpose of this work is to investigate the effect of secondary fragments on the image quality of helium CT (HeCT) and to assess the performance of a prototype proton CT (pCT) scanner when operated with helium beams in Monte Carlo simulations and experiment. Experiments were conducted installing the U.S. pCT consortium prototype scanner at the Heidelberg Ion-Beam Therapy Center (HIT). Simulations were performed with the scanner using the TOPAS toolkit. HeCT images were reconstructed for a cylindrical water phantom, the CTP404 (sensitometry), and the CTP528 (line-pair) ® modules. To identify and remove individual events caused by fragmentation, the multistage energy detector of the scanner was adapted to function as a telescope. The use of the developed filter eliminated the otherwise arising ring artifacts in the HeCT reconstructed images. For the HeCT reconstructed images of a water phantom, the maximum RSP error was improved by almost a factor 8 with respect to unfiltered images in the simulation and a factor 10 in the experiment. Similarly, for the CTP404 module, the mean RSP accuracy improved by a factor 6 in both the simulation and the experiment when the filter was applied (mean relative error 0.40% in simulation, 0.45% in experiment). In the evaluation of the spatial resolution through the CTP528 module, the main effect of the filter was noise reduction. For both simulated and experimental images the spatial resolution was ∼4 lp cm−1. In conclusion, the novel filter developed for secondary fragments proved to be effective in improving the visual quality and RSP accuracy of the reconstructed images. With the filter, the pCT scanner is capable of accurate HeCT imaging.
    Note: Gesehen am 29.03.2019
    In: Physics in medicine and biology, Bristol : IOP Publ., 1956, 63(2018,19) Artikel-Nummer 195016, 15 Seiten, 1361-6560
    In: volume:63
    In: year:2018
    In: number:19
    In: extent:15
    Language: English
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  • 6
    UID:
    (DE-627)1729168299
    Format: 23
    ISSN: 1361-6560
    Content: The physical range uncertainty limits the exploitation of the full potential of charged particle therapy. In this work, we face this issue aiming to measure the absolute Bragg peak position in the target. We investigate p, 4He, 12C and 16O beams accelerated at the Heidelberg Ion-Beam Therapy Center. The residual range of the primary 12C ions is correlated to the energy spectrum of the prompt gamma radiation. The prompt gamma spectroscopy method was demonstrated for proton beams accelerated by cyclotrons and is developed here for the first time for heavier ions accelerated by a synchrotron. We develop a detector system that includes (i) a spectroscopic unit based on cerium(III) bromide and bismuth germanium oxide scintillating crystals, (ii) a beam trigger based on an array of scintillating fibers and (iii) a data acquisition system based on a FlashADC. We test the system in two different scenarios. In the first series of experiments, we detect and identify 19 independent spectral lines over a wide gamma energy spectrum in the presence of the four ion species for different targets, including a water target with a titanium insert. In the second series of experiments, we introduce a collimator aiming to relate the spectral information to the range of the primary particles. We perform extensive measurements for a 12C beam and demonstrate submillimetric precision for the measurement of its Bragg peak position in the experimental setup. The features of the energy and time spectra for gamma radiation induced by p, 4He and 16O are investigated upstream and downstream from the Bragg peak position. We conclude the analysis by extrapolating the required future developments, which would be needed to achieve range verification with a 2 mm accuracy during a single fraction delivery of physical dose.
    Note: Die Zahl "12" ist im Haupttitel hochgestellt , Gesehen am 09.09.2020
    In: Physics in medicine and biology, Bristol : IOP Publ., 1956, 65(2020,9) Artikel-Nummer 095010, 23 Seiten, 1361-6560
    In: volume:65
    In: year:2020
    In: number:9
    In: extent:23
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 7
    UID:
    (DE-627)1575547732
    Format: 22
    ISSN: 1361-6560
    Content: Until now, the dosimetry of carbon ions with ionization chambers has not reached the same level of accuracy as that of high-energy photons. This is mainly caused by the approximately threefold larger uncertainty of the kQ factor of ionization chambers, which, due to the lack of experimental data, is still derived by calculations. Measurements of absorbed dose to water, Dw , by means of water calorimetry have now been performed in the entrance channel of a scanned 6 cm × 6 cm radiation field of 429 MeV/u carbon ions, allowing the direct calibration of ionization chambers and thus the experimental determination of kQ . Within this work, values for kQ have been determined for the Farmer-type ionization chambers FC65-G and TM30013. A detailed investigation of the radiation field enabled the accurate determination of correction factors needed for both calorimetric and ionometric measurements. Finally, a relative standard measurement uncertainty of 0.8% ( k = 1) could be achieved for the experimental kQ values. For both chambers, the experimental kQ factors were found to be about 1% larger than those tabulated in the German DIN 6801-1 protocol, whereas compared to the theoretical values stated in the TRS-398 protocol, the experimental kQ value agrees within 0.4% for the TM30013 chamber but is about 1% lower in the case of the FC65-G chamber.
    Note: Im Titel und in der Beschreibung ist bei der Zeichenfolge kQ das Q immer tiefgestellt , Gesehen am 28.05.2018
    In: Physics in medicine and biology, Bristol : IOP Publ., 1956, 62(2017), 6, Seite 2033-2054, 1361-6560
    In: volume:62
    In: year:2017
    In: number:6
    In: pages:2033-2054
    In: extent:22
    Language: English
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  • 8
    UID:
    (DE-627)1555904475
    Format: 30
    ISSN: 1361-6560
    Note: Gesehen am 24.03.2017
    In: Physics in medicine and biology, Bristol : IOP Publ., 1956, 60(2015), 2, Seite 565-594, 1361-6560
    In: volume:60
    In: year:2015
    In: number:2
    In: pages:565-594
    In: extent:30
    Language: English
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  • 9
    UID:
    (DE-627)1526872390
    Format: 6
    ISSN: 1742-3406
    Note: Gesehen am 02.03.2016
    In: Radiation protection dosimetry, Ashford : Oxford Univ. Press, 1981, 161(2014), 1/4, Seite 387-392, 1742-3406
    In: volume:161
    In: year:2014
    In: number:1/4
    In: pages:387-392
    In: extent:6
    Language: English
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  • 10
    UID:
    (DE-627)1820254828
    Format: 15 , Illustrationen
    ISSN: 1361-6560
    Content: Scanned ion pencil beams carry a low-dose envelope which can extend up to several centimeters from the individual beam central axis. Depending on the energy and species of the beam, this halo consists mainly of secondary particles produced by nuclear interactions in the target or of particles undergoing multiple Coulomb scattering in the beam line components. This halo is often neglected by single Gaussian beam modeling in current treatment planning systems. One possibility of improving the accuracy of treatment planning is to upgrade the used pencil beam models by adding a description of the low-dose envelope. But at the same time it is crucial to keep the calculation time and the complexity for treatment planning in reasonable limits. As a first approach we measured the lateral beam profiles of scanned proton and carbon ion pencil beams at different energies and depths in water and air at the Heidelberg Ion Beam Therapy Center. Then we tried to describe their beam halo by adding a supplementary Gaussian function to the standard single Gauss modeling which is used at the moment by our treatment planning systems. This analysis helped to identify trends in the parameters describing the lateral beam broadening to support its modeling. Finally, it is shown that the accuracy of treatment planning could be improved by the proposed upgrade of the pencil beam model. In particular, the presented experimental data can be either used directly as input for dose calculation or serve for representative comparison with the results of calculation models such as Monte Carlo simulations for the generation of lateral basic data to be input in upgraded beam models of treatment planning systems.
    Note: Gesehen am 28.10.2022
    In: Physics in medicine and biology, Bristol : IOP Publ., 1956, 56(2011), 24 vom: Nov., Seite 7813-7827, 1361-6560
    In: volume:56
    In: year:2011
    In: number:24
    In: month:11
    In: pages:7813-7827
    In: extent:15
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Volltext  (lizenzpflichtig)
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