Format:
17
ISSN:
2041-1723
Content:
SuFu is a tumour suppressor in medulloblastoma and regulates Gli proteins in the Sonic Hedgehog pathway; however, the molecular mechanisms behind this regulation are unclear. Here, the authors show that the Itch/β-arrestin2 complex binds and ubiquitylates SuFu, facilitating the interaction with Gli3 and its conversion into the repressive form, thus counteracting medulloblastoma formation.
Note:
Gesehen am 17.02.2020
In:
Nature Communications, [London] : Nature Publishing Group UK, 2010, 9(2018) Artikel-Nummer 976, 17 Seiten, 2041-1723
In:
volume:9
In:
year:2018
In:
extent:17
Language:
English
DOI:
10.1038/s41467-018-03339-0
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