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  • BSZ  (3)
Type of Material
Type of Publication
Consortium
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  • 1
    Online Resource
    Online Resource
    Tumor Antigen Carcinoembryonic Antigen Inhibits Human CD4 Helper T Cell Activation (2012)
    [Erscheinungsort nicht ermittelbar] : 서울대학교 대학원
    Details
    UID:
    (DE-627)1803933224
    Content: 학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2012. 2. 강창율. ; Carcinoembryonic antigen (CEA) is a well-known tumor antigen. It is found in serum of various cancers including colorectal carcinoma, gastric carcinoma. Uncontrolled level of CEA in individuals increases the risk of recurrence and metastasis. In this study we show that CEA can directly inhibit human PBMC derived CD4+ T cell activation. When cultured with plate-bound human recombinant CEA under anti-CD3, CD28 stimulation, CD4+ T cells showed decreased proliferation and cytokine production. Soluble form of CEA did not show such effect. Following stimulation the level of CD69, phosphorylated ZAP70, phosphorylated ERK was decreased in CEA treated CD4+ T cells as early as 4 hours post stimulation. When treated with SHP inhibitor (NSC-87877) proliferation was restored, showing that the inhibitory effect was mediated by SHP. To show the physiological relevance of CEA mediated inhibition, we used CEA overexpressing murine colon adenocarcinoma cell line (MC38-CEA) and co-cultured it with human CD4+ T cells. As expected, CD4+ T cells cultured with MC38-CEA showed decreased proliferation but those cultured with MC38 did not. This suggests that impaired T cell response mediated by CEA can be a possible mechanism of tumor evasion. ; Master
    Note: Dissertation 서울대학교 대학원 2012
    Language: English
    URL: kostenfrei
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    BSZ
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  • 2
    Book
    Book
    Segye ŭi sŏsa munhak kwa "T'oji" (2008)
    Sŏul-si : Sŏjŏng Sihak
    Details
    UID:
    (DE-627)1468988417
    Format: 487 S. , Ill. , 24 cm
    Edition: Ch'op'an
    Original writing edition: 초판
    Original writing title: 세계의 서사문학과 "土地"
    Original writing person/organisation: 최유찬
    Original writing publisher: 서울시 : 서정시학
    ISBN: 9788992362405 , 8992362404
    Series Statement: Sŏjŏng sihak sinsŏ 8
    Note: In korean. Schrift, korean
    Language: Korean
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    BSZ
  • 3
    Book
    Book
    Han'guk kŭndae munhwa wa Pak Kyŏng-ni ŭi "T'oji" : = Korean modern culture and Park Kyong-ni's "Toji" (2008)
    Sŏul-si : Somyŏng Ch'ulp'an
    Details
    UID:
    (DE-627)1606523082
    Format: 349 S. , 24 cm
    Edition: 1-p'an
    Original writing edition: 1판
    Original writing title: 한국 근대문화와 박경리의 "토지"
    Original writing person/organisation: 최유찬
    Original writing publisher: 서울시 : 소명출판
    ISBN: 9788956263489 , 8956263485
    Note: In korean. Schrift, korean
    Language: Korean
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    Book
    BSZ
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