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Format: Online-Ressource , v.: digital

Edition: Online-Ausg. Springer eBook Collection. Medicine Electronic reproduction; Available via World Wide Web

ISBN: 9781617794070

Series Statement: Current Clinical Oncology

Content: Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas - over-exposure to ultraviolet light - is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal t

Note: Description based upon print version of record , Targeted Therapeuticsin Melanoma; Preface; Cracking the Melanoma Nut; Acknowledgments; Contents; Contributors; Part I: Advances in Melanoma Biology; Chapter 1: Molecular Targets and Subtypes in Melanoma; Introduction; BRAF; NRAS; PI3K-AKT Pathway; c-KIT; GNAQ; Conclusions; References; Chapter 2: Melanoma Genomics; Gene Expression Profiling of Distinct Phases of Melanoma Progression; Gene Expression Profiles of Primary Melanoma; Gene Expression Profiling of Metastatic Melanoma; Conclusions; References; Chapter 3: Predictive Biomarkers as a Guide to Future Therapy Selection in Melanoma , Evidence for Existence of Biologic Subsets of MelanomaKinase Mutations and Clinical Response to Kinase Inhibitors; B-Raf; c-kit; New Pathways Showing Heterogeneity Among Individual Melanoma Patients; Gene Expression Profiling and Clinical Response to Melanoma Vaccines; Molecular Features Associated with Response to Chemotherapy; Biomarkers as a Tool to Determine Mechanisms of Therapeutic Resistance; Predictive Biomarkers from Non-Tumor Tissue: Serum and Germline DNA; The Evolving Future of Melanoma Therapy; References; Part II: Signaling Molecules as Molecular Targets , Chapter 4: KIT as a Therapeutic Target for MelanomaIntroduction; KIT as a Proto-Oncogene; The Role of KIT in Cancer; KIT Tyrosine Kinase Inhibitors; Overcoming Resistance to Tyrosine Kinase Inhibition; Is KIT Amplification or Mutation More Important?; Conclusions; References; Chapter 5: Targeted Inhibition of B-Raf; Introduction; The MAPK Pathway; BRAF Mutations in Melanoma; Preclinical Studies; RAF Inhibition of BRAF Wild-Type Cells Leads to Activation of the MAPK Pathway; RAF Inhibition of BRAF-Mutated Melanoma Causes Melanoma Cell Death , Clinical Studies with the RAF Inhibitor PLX4032 (RO5185426)Spectrum of BRAF Inhibitors in Clinical Trials; MEK Inhibition as a Strategy for Targeting BRAF Mutant Melanoma; Resistance Mechanisms Observed in Clinical Trials; Future Directions for BRAF Inhibitors; References; Chapter 6: The Notch and b -Catenin Pathways; Notch Signaling; Notch and Cancer; Targeting Notch in Melanoma; b -catenin Signaling; Wnt/ b -catenin and Cancer; Targeting b -catenin in Melanoma; Perspective; References; Chapter 7: STAT3 and Src Signaling in Melanoma; Introduction; STAT3 and Src Signaling in Melanoma , STAT3/Src Regulation of Tumor Cell GrowthSTAT3 and Src Activity Promote Angiogenesis and Metastasis in Melanoma; STAT3 Signaling in Tumor-Associated Immune Cells: Their Role in Melanoma Development; Treatment of Melanoma by STAT3-Targeted Therapy; Inhibition of STAT3 Activation in Melanoma via Small-Molecule Inhibitors; Conclusions; References; Chapter 8: Targeting the mTOR, PI3K, and AKT Pathways in Melanoma; mTor Overview: Normal Functions and Genetic Alterations of Importance in Melanoma; Upstream Effectors of mTOR Activation: PTEN, PI3K, and AKT , mTOR Complexes and Downstream Events: Control of Transcription , Electronic reproduction; Available via World Wide Web

Additional Edition: 9781617794063

Language: English

DOI: 10.1007/978-1-61779-407-0

URL: Volltext  (lizenzpflichtig)

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Format: 1 online resource (376 pages)

ISBN: 9781617794070

Series Statement: Current Clinical Oncology Ser.

Content: This book describes recent ground-breaking developments in melanoma treatment in the arena of targeted therapeutics. The contents explore both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies.

Content: Intro -- Targeted Therapeutics in Melanoma -- Preface -- Cracking the Melanoma Nut -- Acknowledgments -- Contents -- Contributors -- Part I: Advances in Melanoma Biology -- Chapter 1: Molecular Targets and Subtypes in Melanoma -- Introduction -- BRAF -- NRAS -- PI3K-AKT Pathway -- c-KIT -- GNAQ -- Conclusions -- References -- Chapter 2: Melanoma Genomics -- Gene Expression Profiling of Distinct Phases of Melanoma Progression -- Gene Expression Profiles of Primary Melanoma -- Gene Expression Profiling of Metastatic Melanoma -- Conclusions -- References -- Chapter 3: Predictive Biomarkers as a Guide to Future Therapy Selection in Melanoma -- Evidence for Existence of Biologic Subsets of Melanoma -- Kinase Mutations and Clinical Response to Kinase Inhibitors -- B-Raf -- c-kit -- New Pathways Showing Heterogeneity Among Individual Melanoma Patients -- Gene Expression Profiling and Clinical Response to Melanoma Vaccines -- Molecular Features Associated with Response to Chemotherapy -- Biomarkers as a Tool to Determine Mechanisms of Therapeutic Resistance -- Predictive Biomarkers from Non-Tumor Tissue: Serum and Germline DNA -- The Evolving Future of Melanoma Therapy -- References -- Part II: Signaling Molecules as Molecular Targets -- Chapter 4: KIT as a Therapeutic Target for Melanoma -- Introduction -- KIT as a Proto-Oncogene -- The Role of KIT in Cancer -- KIT Tyrosine Kinase Inhibitors -- Overcoming Resistance to Tyrosine Kinase Inhibition -- Is KIT Amplification or Mutation More Important? -- Conclusions -- References -- Chapter 5: Targeted Inhibition of B-Raf -- Introduction -- The MAPK Pathway -- BRAF Mutations in Melanoma -- Preclinical Studies -- RAF Inhibition of BRAF Wild-Type Cells Leads to Activation of the MAPK Pathway -- RAF Inhibition of BRAF-Mutated Melanoma Causes Melanoma Cell Death.

Note: Description based on publisher supplied metadata and other sources

Additional Edition: 9781627038768

Additional Edition: Erscheint auch als Druck-Ausgabe 9781627038768

Language: English

URL: lizenzpflichtig

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Format: 1 Online-Ressource (440 p) , Mit 34 Abbildungen und 2 Tabellen

Edition: Reprint 2021

Edition: [Online-Ausgabe]

ISBN: 9783112484326

Series Statement: Abhandlungen der Akademie der Wissenschaften der DDR/ N. Mathematik, Naturwissenschaften, Technik 1981, 2

Content: Frontmatter -- Preface -- Contents -- Invited Lectures -- Saddle points and nonlinear differential equations -- On optimal control problems described by operator equations in Banach and Hilbert spaces -- Regularity results for some elliptic variational inequalities with bounded measurable coefficients and applications -- Nonlinear equality constraints in optimization problems with set restrictions -- On the speed of c0-sequences in connection with a lemma of Toeplitz -- On some optimal control problems for elliptic systems in the plane -- On an initial-boundary value problem for the nonlinear Schrödinger equation with selfconsistent potential -- On initial value problems in thermodynamics -- Common properties of nonlinear programming algorithms basing on sequential unconstrained minimizations -- The finite-difference method for a mildly nonlinear elliptic problem -- Finite element analysis of the unilateral contact between elastic bodies -- An inverse problem for "coefficients" in linear equations. Uniqueness and iterative solution -- Nonlinear operators and solvability of operator equations -- On convergence properties of families of maximal monotone operators -- On perturbation of branching problems and secondary branching in the theory of plates -- On a program for the computation of matter transport in river networks -- Existence and regularity theorems for weak solutions to the equations of motion of visco-plastic media -- A necessary and sufficient condition for the regularity of weak solutions to nonlinear elliptic systems of partial differential equations -- Problems in connection with the Hahn-Banach Theorem -- Parabolic problems with free boundaries: Existence and properties of solutions; optimal control problems -- Optimization methods for non-linear partial differential equations -- Design sensitivity analysis in structural mechanics -- On optimal control problems in civil-engineering and technology -- Das asymptotische Verhalten von Toeplitzdeterminanten für einige Klassen von Erzeugerfunktionen -- Optimization and best approximation -- Control in coefficients for PDE -- Towards a general-purpose difference scheme for the linear one-dimensional parabolic equation -- Two-component flow round a solid sphere -- To the mathematical treatment of a technical heat control problem -- Communications -- On the radius of a set in a Hilbert space -- On the variational method without coerciveness -- Special control problems and monotone operators -- A generalization of an optimality theorem -- Mixed variational formulation of unilateral problems -- Sufficient conditions for optimality of a control problem with discrete time -- A controllability problem of nonlinear dynamical systems -- On the convergence of the finite elements method for some initial problem -- On the normality of Lagrange multiplier rules for optimal control problems -- Some methods of solving optimal control problems for free boundary processes -- Ein Approximations-Iterationsverfahren für nichtlineare Volterrasche Integralgleichungen zweiter Art -- Secondary axisymmetric buckled states of thin elastic spherical shells -- Perturbation and branching of the solutions of nonlinear eigenvalue problems -- Zur Existenz der optimalen Steuerung bei Volterraschen Integralgleichungen -- The finite difference method for quasilinear elliptic equations with rapidly increasing coefficients -- A constructive proof of the implicit function theorem for analytic operators -- Some remarks to existence problems of optimal control for parabolic equations -- Construction of local solutions for Maxwell equations -- An abstract equation modelling diffusion in solids with bidisperse pore structure -- Bifurcation of axially compressed circular cylindrical shells with free edges -- On difference approximations of a class of it-dimensional variational inequalities -- On some Stefan like problem -- On a system of nonlinear partial differential equations arising in the theory of heat and mass transfer in a nonlinear second-order fluid

Note: Mode of access: Internet via World Wide Web. , In German

Additional Edition: 9783112484319

Additional Edition: Erscheint auch als print 9783112484319

Language: German

DOI: 10.1515/9783112484326

URL: lizenzpflichtig

URL: lizenzpflichtig

URL: Cover