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  • GBV  (12)
Type of Material
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  • 1
    UID:
    (DE-627)1048266265
    Format: 379 Seiten , 24 cm
    ISBN: 9788862748964
    Series Statement: Classica philosophica et iuridica 4
    Note: Valerius Harpocration, Ancient Greek grammarian , Critical matter in Italian; includes texts in original Ancient Greek with parallel Italian translation
    Language: Italian
    Keywords: Harpocration, Valerius Lexicon in decem oratores Atticos ; Kommentar ; Quelle
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  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)1828022608
    Content: The main aim of this project was to uncover the spatiotemporal events influencing type I interferon (IFN-I) dynamics during the early phase of acute and chronic viral infections. Time-resolved spleen-transcriptome analysis of LCMV-infected mice revealed two waves of IFN-I expression in acute infection, while in chronically infected mice a single wave of IFN-I genes was induced. We identified CD169+ macrophages as the source of the second wave of IFN-I only during acute infection, and characterized its polyfunctional role involving (i) the induction of pro-inflammatory macrophages, and (ii) the expansion of virus-specific CD8 T cells. Importantly, the IFN-I-mediated antiviral CD8 T cell response resulted in the development of fibrosis in lymphatic tissue. In contrast, during chronic infection the early CD8 T cell-mediated depletion of CD169+ macrophages resulted in a lack of IFN-I production and the subsequent IFN-I-mediated-pro-inflammatory response. Overall, we demonstrated that the spatiotemporal regulation of IFN-I production in the early stages of infection is crucial for the induction of sequential immune events that lead to viral infection resolution. ; El objetivo principal de este proyecto fué analizar los eventos espacio-temporales que determinan la dinámica de la respuesta de interferón de tipo I (IFN-I) durante la fase inicial de las infecciones virales agudas o crónicas. El análisis de los transcriptomas de bazos de ratones infectados por LCMV reveló dos olas de expresión de IFN-I durante la infección aguda, en contraste con un único pico de expresión durante una infección crónica. Estudios posteriores permitierón demostrar que la segunda ola de producción de IFN-I durante una infección aguda está mediada por macrófagos CD169+, y que entre sus funciones se encuentran la inducción de (i) macrófagos proinflamatorios, y (ii) células T CD8 antivirales, las cuales son finalmente responsables de la aparición de fibrosis en tejido linfático. Por otro lado, durante una infección crónica los macrófagos CD169+ ...
    Note: Dissertation 2021
    Language: English
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  • 3
    Book
    Book
    Milano : LED
    UID:
    (DE-627)1042068488
    Format: 160 p , 24 cm
    ISBN: 9788879168724
    Note: Includes indexes
    Language: Italian
    Keywords: Stipulatio ; Vererblichkeit
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  • 4
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)1802824898
    Content: Exon Skipping has been demonstrated to be a successful strategy for the gene therapy of Duchenne Muscular Dystrophy (DMD): the rational is to convert severe Duchenne forms into milder Becker ones. Here we show the selection of U1 snRNA-antisense constructs able to confer effective rescue of dystrophin synthesis in a Δ44 Duchenne genetic background, through skipping of exon 45; moreover, we demonstrate that the resulting dystrophin is able to recover the correct timing of myogenic marker expression, to re-localize nNOS and to rescue expression of miRNAs previously shown to be sensitive to the Dystrophin-nNOS-HDAC2 pathway. Becker mutations display different phenotypes, likely depending on whether the shorter protein is able to reconstitute the wide range of wild type functions. Among them, efficient assembly of the dystrophin associated protein complex (DAPC) and Nitric Oxide Synthase (nNOS) localization are important. Comparing different Becker deletions we demonstrate the correlation between the ability of the mutant dystrophin to re-localize nNOS and the expression levels of two miRNAs, miR-1 and miR29c, known to be involved in muscle homeostasis and to be controlled by the Dys-nNOS-HDAC2 pathway. Since the gene responsible for the disease has been identified, several aberrant pathways have been characterized and many therapeutic approaches have been proposed to face all the symptoms associated to the pathology. What is now quite clear is that the best way to cure the disease is to apply different strategies in parallel, to enhance the beneficial effect that could be obtained from a single treatment. With this concept in mind we identified a microRNA, miR-31, that is deregulated in DMD conditions if compared to a healthy control. This miRNA represses dystrophin expression by targeting its 3′UTR region. In human DMD myoblasts treated with exon skipping, we demonstrate that miR-31 inhibition increases dystrophin rescue. These results indicate that interfering with miR-31 activity can provide an ameliorating strategy for those DMD therapies that are aimed at efficiently recovering dystrophin synthesis. ; PARENT PROJECT ONLUS; TELETHON
    Note: Dissertation 2013
    Language: English
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  • 5
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)1802824901
    Content: Exon Skipping has been demonstrated to be a successful strategy for the gene therapy of Duchenne Muscular Dystrophy (DMD): the rational is to convert severe Duchenne forms into milder Becker ones. Here we show the selection of U1 snRNA-antisense constructs able to confer effective rescue of dystrophin synthesis in a Δ44 Duchenne genetic background, through skipping of exon 45; moreover, we demonstrate that the resulting dystrophin is able to recover the correct timing of myogenic marker expression, to re-localize nNOS and to rescue expression of miRNAs previously shown to be sensitive to the Dystrophin-nNOS-HDAC2 pathway. Becker mutations display different phenotypes, likely depending on whether the shorter protein is able to reconstitute the wide range of wild type functions. Among them, efficient assembly of the dystrophin associated protein complex (DAPC) and Nitric Oxide Synthase (nNOS) localization are important. Comparing different Becker deletions we demonstrate the correlation between the ability of the mutant dystrophin to re-localize nNOS and the expression levels of two miRNAs, miR-1 and miR29c, known to be involved in muscle homeostasis and to be controlled by the Dys-nNOS-HDAC2 pathway. Since the gene responsible for the disease has been identified, several aberrant pathways have been characterized and many therapeutic approaches have been proposed to face all the symptoms associated to the pathology. What is now quite clear is that the best way to cure the disease is to apply different strategies in parallel, to enhance the beneficial effect that could be obtained from a single treatment. With this concept in mind we identified a microRNA, miR-31, that is deregulated in DMD conditions if compared to a healthy control. This miRNA represses dystrophin expression by targeting its 3′UTR region. In human DMD myoblasts treated with exon skipping, we demonstrate that miR-31 inhibition increases dystrophin rescue. These results indicate that interfering with miR-31 activity can provide an ameliorating strategy for those DMD therapies that are aimed at efficiently recovering dystrophin synthesis.
    Note: Dissertation 2013
    Language: English
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  • 6
    UID:
    (DE-627)1699641129
    Format: 1 online resource (256 pages)
    ISBN: 9782503586892
    Series Statement: Giornale Italiano Di Filologia - Bibliotheca Ser. v.21
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9782503586885
    Additional Edition: Erscheint auch als Druck-Ausgabe 9782503586885
    Language: English
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  • 7
    UID:
    (DE-627)1683618688
    Format: 256 Seiten
    ISBN: 9782503586885 , 2503586880
    Series Statement: Giornale Italiano di Filologia 21
    Content: In the wider context of the border conflicts that involve Rome as a third authority 'super partes', for which there is already evidence in the second century BC, two epigraphic documents stand out for the peculiarities distinguishing them from all others: the so-called Polcevera Tablet (concerning a dispute between Genuates and Viturii Langenses) and the Cippus Abellanus (related to a border dispute between Nolani and Abellani and written in Oscan). They make us aware of the political and municipal dynamics underlying the complex principle of Roman arbitration, often required to resolve territorial disputes, which were gradually evolving as Rome opened up to the East. What role did the Roman Senate play in such disputes? What exactly was the function of the referees sent by the City to settle the disputes with a super partes judgment? What was the importance of the agrarian reform of the Gracchi and the realisation of road axes in the acuity of such antagonisms? These are the questions which this study tries to an answer
    Additional Edition: 9782503586892
    Language: English
    Keywords: Senatus consultum ; Fallstudie ; Schlichtung
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  • 8
    UID:
    (DE-627)1792057628
    Format: 1 Online-Ressource
    Content: This paper investigates the main elements that can influence customer satisfaction in tourist services, with specific reference to tourism industry. The importance of this topic resides in the fact that tourists' positive experiences of service, products, and other resources provided by tourism destinations can produce customer retention as well as positive word-of-mouth. Indeed, satisfaction with travel experiences contributes to destination loyalty. The degree of tourists' loyalty to a destination is reflected in their intentions to revisit the destination and in their recommendations to others. Thus, information about tourists' loyalty is important to destination marketers and managers in order to sustain destination attractiveness. Although predominant literature has adopted a demand-side perspective, this paper analyses tourist satisfaction according to an overlapping perspective that contemplates both the demand and the offer side where this latter, in the wider meaning, also includes the systemic perspective. More precisely, this paper aims to identify the principle competitive strategies that the variety of stakeholders, cooperating together in a destination, has to implement in order to increase tourist satisfaction and loyalty. Indeed, the point of view of this paper is to understand how destination attributes and services affect the tourist satisfaction.In order to study the link between destination attributes and tourist satisfaction, the paper collects cross-sectional data via questionnaire, from May 2012 to May 2013. The adopted approach allows to individuate the factors that can influence tourist satisfaction, their (positive or negative) direction and their magnitude. This paper uses 14 tourist satisfaction indicators in order to measure the global satisfaction. Furthermore, this study allows to identify the current strengths and weaknesses of the tourist offer. In particular, the study paid attention to the phase of service delivery since it is the time when customer satisfaction is generated. From this study, it comes out that tourist satisfaction depends on a complex process where the role of each actor is fundamental and it must be in tune with all the other ones. Findings show that tourists visiting Naples are not completely satisfied, supporting that Naples has not a clear destination image
    Note: Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments January 27, 2015 erstellt , Volltext nicht verfügbar
    Language: English
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  • 9
    UID:
    (DE-627)1792023723
    Format: 1 Online-Ressource (12 p)
    Content: This paper investigates the main elements that can influence customer satisfaction in tourist services, with specific reference to tourism industry. The importance of this topic resides in the fact that tourists' positive experiences of service, products, and other resources provided by tourism destinations can produce customer retention as well as positive word-of-mouth. Indeed, satisfaction with travel experiences contributes to destination loyalty. The degree of tourists' loyalty to a destination is reflected in their intentions to revisit the destination and in their recommendations to others. Thus, information about tourists' loyalty is important to destination marketers and managers in order to sustain destination attractiveness. Although predominant literature has adopted a demand-side perspective, this paper analyses tourist satisfaction according to an overlapping perspective that contemplates both the demand and the offer side where this latter, in the wider meaning, also includes the systemic perspective. More precisely, this paper aims to identify the principle competitive strategies that the variety of stakeholders, cooperating together in a destination, has to implement in order to increase tourist satisfaction and loyalty.Indeed, the point of view of this paper is to understand how destination attributes and services affect the tourist satisfaction. In order to study the link between destination attributes and tourist satisfaction, the paper collects cross-sectional data via questionnaire, from May 2012 to May 2013. The adopted approach allows to individuate the factors that can influence tourist satisfaction, their (positive or negative) direction and their magnitude. This paper uses 14 tourist satisfaction indicators in order to measure the global satisfaction. Furthermore, this study allows to identify the current strengths and weaknesses of the tourist offer. In particular, the study paid attention to the phase of service delivery since it is the time when customer satisfaction is generated. From this study, it comes out that tourist satisfaction depends on a complex process where the role of each actor is fundamental and it must be in tune with all the other ones. Findings show that tourists visiting Naples are not completely satisfied, supporting that Naples has not a clear destination image
    Note: In: Journal of Investment and Management 2015 , In: 4(1-1): 39-50 , Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments 2015 erstellt
    Language: English
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  • 10
    UID:
    (DE-627)1792057652
    Format: 1 Online-Ressource (89 p)
    Series Statement: Chinese Business Review Vol. 11, No. 11, 996-1014, November 2012
    Content: The issue of employer branding has always had an intrinsic interdisciplinary content, since it builds a bridge for cross-fertilization between different disciplines (strategic marketing, strategic management, and human resources management). This paper presents employer branding as an approach based on effective strategic organizationalresources and a precise employer branding management process. In this paper, the target is to define a possible frame in order to interpret employer branding techniques as control and regulation mechanisms. Control in organizations has long been a topic of interest for researchers and practitioners, alike who generally recognize that control mechanisms are needed to ensure that organizations may achieve their goals. It has been carried out a field work on the Italian Aeronautical Meta district, that generates annual revenues equal to EUR 8.7 billion and employees 36,300 people, of whom approximately 10% are employed in the space sector. Through this field work, the intention aim is to understand if and how employer branding may create, enforce, and set up internal and shared meaning and values. In particular, stemming from the empirical research's evidences, this paper tries to conceptualize employer branding as a factor to persuade and influence the way that organizational actors enact in a socially constructed context. In this effort, the aim is to understand how managers may affect meanings, values, goals, and opinions through an effective action on employer branding that can play a crucial role in affecting sense-making processes, meanings, interpretations of the symbolic environment. The paper therefore opens up to new horizons, since it embraces a new application for employer branding, considering it as a modern control system and proposing an innovative approach in managerial control, founded on organizational identity as a key concept in an organizational citizenship's perspective
    Note: Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments January 27, 2015 erstellt
    Language: English
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