Format:
1 Online-Ressource (PDF-Datei: 68 Seiten, 3290 Kilobyte)
,
Illustrationen (farbig), Diagramme (teilweise farbig)
Content:
Chirurgie, Kupffer-Zelle, Leber, Sepsis
Content:
The cholinergic anti-inflammatory pathway represents a neuro-immunological reflex that exerts an inhibitory effect on immune cells in local and generalised inflammation. This pathway is mediated via the α7-subtype of nicotinic acetylcholine receptors on macrophages. Kupffer cells in the liver account for 80 – 90 % of all tissue macrophages. The neuro-immunological control of peritoneal and alveolar macrophages by the vagal nerve is well-documented. However, little is known about the interplay of the cholinergic anti-inflammatory pathway and Kupffer cells. This study investigated the vagal influence on Kupffer cells. Nicotine, an agonist of the α7-subtype nicotinic acetylcholine receptor, didn't alter the in vitro LPS-induced cytokine release of Kupffer cells from C57Bl/6 mice. However, complete subdiaphragmatic vagotomy lead to lower levels of LPS-induced TNF-α in supernatants of murine Kupffer cells. This study provides novel evidence of a neuro-immunological interaction between the vagal nerve and the resident macrophages of the liver. In contrast to peritoneal and alveolar macrophages however, these findings suggest a pro-inflammatory effect of the vagal nerve on Kupffer cells.
Note:
Literaturverzeichnis: Seite 53-58
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Dissertation Universitätsmedizin der Universität Greifswald 2018
Additional Edition:
Erscheint auch als Druck-Ausgabe Ebker, Tobias, - 1982- Die Rolle der Leber im cholinergen antiinflammatorischen Signalweg unter besonderer Betrachtung der Kupffer-Zellen Greifswald, 2017
Language:
German
Keywords:
Kupffer-Sternzelle
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Leber
;
Sepsis
;
Hochschulschrift
URN:
urn:nbn:de:gbv:9-opus-24701
URL:
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