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Berlin Brandenburg

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  • 1
    Language: English
    In: The Journal of Pediatrics, 1986, Vol.108(2), pp.247-249
    Keywords: Medicine
    ISSN: 0022-3476
    E-ISSN: 1097-6833
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  • 2
    Language: English
    In: The Journal of Pediatrics, 1986, Vol.108(2), pp.169-177
    Description: To document pulmonary function abnormalities in children with sarcoidosis, we reviewed the records of all children with this disease at the North Carolina Memorial Hospital. Spirometry was performed by 34 of 60 children at initial presentation and was repeated by 16 at least 1 yr after presentation (mean, 3.9 yr). Those with and without pulmonary function data available were similar in age, sex, race, and clinical manifestations at presentation. Results indicate that at presentation, 50% of children had the characteristic functional changes of restrictive lung disease (mean % predicted FVC, 79.8 +/- 16.0). Fifteen percent had a FVC of 70 to 80% predicted, 32% had a FVC of 50 to 70% predicted, and 3% had a FVC less than 50% predicted. The TLC and FRC supported the diagnosis of restrictive lung disease. There were 15% who had obstructive changes. Children with auscultatory abnormalities and parenchymal changes on chest radiograph had more severe decrements in pulmonary function; however, specific symptoms did not predict decrements in pulmonary function. There was significant improvement in lung function at the last pulmonary function test performed (mean % predicted FVC, 97.1 +/- 18.8).
    Keywords: Medicine
    ISSN: 0022-3476
    E-ISSN: 1097-6833
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  • 3
    Language: English
    In: The Journal of Pediatrics, 1986, Vol.109(5), pp.835-838
    Keywords: Medicine
    ISSN: 0022-3476
    E-ISSN: 1097-6833
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: The Journal of Infectious Diseases, 1 July 1986, Vol.154(1), pp.100-109
    Description: Eighty-six nasopharyngeal isolates of Haemophilus influenzae were prospectively obtained from three children who attended a day care center from infancy until early childhood (five to seven years). A majority of the strains were nontypable. We analyzed strains by comparing their biotypes and by performing electrophoresis of outer membrane proteins on polyacrylamide gels. Profiles of outer membrane proteins were very heterogeneous and could not be used as the basis for the development of a subtyping scheme. The children characteristically carried a nasopharyngeal strain defined by a unique outer membrane pattern for a period of months, lost it, and then acquired a new strain. We probed the outer membrane proteins of a child's strains by the western blot technique with serum obtained serially from the child. Isolates whose outer membrane proteins appeared identical on stained gels generally had similar antigenic bands on western blots but were occasionally immunologically distinct. Serum immunoglobulins of the IgG class that reacted with the outer membrane proteins did not appear to change greatly over time or to play a role in preventing or terminating colonization. We conclude that nasopharyngeal colonization in children by nontypable H. influenzae is a dynamic process and that factors that cause loss and acquisition of strains remain to be determined
    Keywords: Biological sciences -- Biology -- Microbiology ; Health sciences -- Medical sciences -- Immunology ; Applied sciences -- Materials science -- Materials ; Health sciences -- Medical sciences -- Immunology ; Behavioral sciences -- Sociology -- Human societies ; Health sciences -- Medical conditions -- Infections ; Health sciences -- Health and wellness -- Public health ; Health sciences -- Medical conditions -- Infections ; Physical sciences -- Chemistry -- Chemical compounds ; Health sciences -- Medical conditions -- Diseases
    ISSN: 00221899
    E-ISSN: 15376613
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