Journal of Bacteriology, Oct, 1992, Vol.174(19-20), p.6455(5)
An analysis of isogenic lipooligosaccharide (LOS) mutants of Haemophilus influenzae type b (Hib) was presented. These LOS mutants were isolated by transposon mutagenesis of the lsg (LOS synthesis genes) loci, that is responsible for modification of the Escherichia coli lipopolysaccharide. The study resulted in the generation of isogenic LOS mutants of Hib A2 that show alterations in oligosaccharide structures and in monoclonal antibodies.
Glycolipids -- Research ; Microbial Mutation -- Research ; Haemophilus Influenzae -- Genetic Aspects
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