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Berlin Brandenburg

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  • 1
    Language: English
    In: Journal of experimental medicine, 1996, Vol.184(3), pp.1185-1189
    Description: CD97 is an activation-induced antigen on leukocytes with a seven-span transmembrane (7-TM) region homologous to the secretin receptor superfamily. However, in contrast to this group of peptide hormone receptors, CD97 has an extended extracellular region with three EGF domains at the NH2 terminus, two of them with a calcium binding site. By demonstrating that lymphocytes and erythrocytes specifically adhere to CD97-transfected COS cells we here show that CD97 in parallel with its molecular evolution has acquired the ability to bind cellular ligands. A mAb selected on its capacity to block the adhesion between CD97 transfectants and red cells was found to be directed to the NH2-terminal short consensus repeat (SCR) of decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The specificity of the interaction of CD97 with CD55 was established by the observation that erythrocytes that lack CD55, obtained from patients with paroxysmal nocturnal hemoglobinuria (PNH) or the CD55, phenotype Inab, failed to adhere to CD97 transfectants. This is the first demonstration of a cellular ligand for a 7-TM receptor
    Keywords: Leukocytes ; Other ; Cd55 Antigen ; Decay-Accelerating Factor ; Cd97 Antigen ; Cd55 Antigen ; Cd97 Antigen ; Decay-Accelerating Factor;
    ISSN: 0022-1007
    ISSN: 1540-9538
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  • 2
    Language: German
    In: Angewandte Chemie, 20 September 1996, Vol.108(18), pp.2228-2230
    Description: werden RNX‐stabilisierte Cobaltcluster mit Sauerstoff zu löslichen, nanostrukturierten Cobalt()‐oxid‐Clustern oxidiert (idealisierte Darstellung unten, dunkle Kugeln: Metallatome, helle Kugeln: Sauerstoffatome, R = CH). Diese dringen – anders als die Co‐Cluster – nicht tief in die Poren von AlO‐Pellets ein, weshalb die so hergestellten Materialien als Schalenkatalysatoren Anwendung finden könnten.
    Keywords: Cluster ; Cobaltverbindungen ; Magnetismus ; Nanostrukturen ; Rastertunnelmikroskopie
    ISSN: 0044-8249
    E-ISSN: 1521-3757
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  • 3
    Language: English
    In: Angewandte Chemie International Edition in English, 01 October 1996, Vol.35(18), pp.2092-2094
    Description: results when cobalt clusters stabilized with RNX are exposed to O. Since the resulting soluble, nanostructured cobalt() oxide clusters (idealized representation below: dark spheres: metal atoms; light spheres: oxygen atoms; R  CH) do not penetrate very far into the pores of AlO pellets, unlike the Co clusters, these materials are potential shell catalysts.
    Keywords: Clusters ; Cobalt Compounds ; Magnetic Properties ; Nanostructures ; Scanning Tunneling Microscopy
    ISSN: 0570-0833
    E-ISSN: 1521-3773
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