Cancer Letters, 1996, Vol.110(1), pp.63-70
The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of apoptosis in malignant cells.
Reduced Glutathione ; S-Acetylglutathione ; Apoptosis ; Flow-Cytometry ; DNA-Fragmentation ; Anti-Tumor Effect ; Medicine
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