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Berlin Brandenburg

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  • 1
    In: Journal of Bacteriology, Feb, 1996, Vol.178(3-4), p.808(9)
    Description: A study was conducted to determine the role of the pili expressed by Haemophilus ducreyi in the pathogenesis of the genital ulcer disease chancroid. A gene encoding the 24K protein of fine, tangled pili, termed ftpA, was isolated and examined by molecular techniques. The results showed that the FtpA protein lacked homology with other pilins, but shared homoloy with proteins that polymerize ordered rings in Escherichia coli and Treponema pallidum.
    Keywords: Hemophilus Infections -- Genetic Aspects
    ISSN: 0021-9193
    E-ISSN: 10985530
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  • 2
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1996, Vol.173(2), pp.394-402
    Description: Human subjects were experimentally infected with Haemophilus ducreyi for up to 2 weeks. Bacterial suspensions were delivered into the epidermis and dermis through puncture wounds made by an allergy-testing device. Subjects developed papular lesions that evolved into pustules resembling natural disease. Some papular lesions resolved spontaneously, indicating that host responses may clear infection. Bacteria were shed intermittently from lesions, suggesting that H. ducreyi may be transmissible before ulceration. Host responses to infection consisted primarily of cutaneous infiltrate of polymorphonuclear leukocytes, Langerhans cells, macrophages, and CD4 T cells of α/β lineage. Expression of HLA-DR by keratinocytes was associated with the presence of interferon-γ mRNA in the skin. There was little evidence for humoral or peripheral blood mononuclear cell responses to bacterial antigens. The cutaneous infiltrate of CD4 cells and macrophages provides a mechanism that facilitates transmission of human immunodeficiency virus by H. ducreyi.
    Keywords: Health sciences -- Medical conditions -- Physical trauma -- Lymphocytes ; Biological sciences -- Biology -- Anatomy -- Lymphocytes ; Health sciences -- Medical sciences -- Immunology -- Lymphocytes ; Health sciences -- Medical conditions -- Infections -- Lymphocytes ; Biological sciences -- Biology -- Physiology -- Lymphocytes ; Biological sciences -- Biology -- Microbiology -- Lymphocytes ; Health sciences -- Medical conditions -- Infections -- Lymphocytes ; Health sciences -- Medical sciences -- Immunology -- Lymphocytes ; Health sciences -- Medical diagnosis -- Diagnostic methods -- Lymphocytes ; Health sciences -- Medical sciences -- Pharmacology -- Lymphocytes
    ISSN: 00221899
    E-ISSN: 15376613
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