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  • 1999  (164)
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  • 1999  (164)
  • 1
    Language: English
    In: M.D. computing : computers in medical practice, 1999, Vol.16(6), pp.46-8
    Description: Physicians should move more aggressively to offer Web-based services because the potential savings are substantial. Some analysts estimate that Web-based medical offices would save the healthcare system up to one quarter of its current costs. Internet companies, such as HealthCentrix and Healtheon/MD, can serve as content providers, connectivity providers, care providers and community providers. Consequently, Web-based medical offices gain revenues through disintermediation, transaction control, data capture and mining and community development. Physicians and other health providers should plan an Internet strategy that includes an advanced Web site, work proactively to connect with managed care organizations, pharmacies, laboratories, and so on. In addition, physicians and Internet companies should work together to derive value from reported data.
    Keywords: Computer Literacy ; Internet ; Office Automation ; Physician'S Role
    ISSN: 0724-6811
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  • 2
    In: Journal of the American Geriatrics Society, November 1999, Vol.47(11), pp.1289-1293
    Description: To determine if endogenous hormone levels predict cognitive function in older women. A longitudinal, population‐based study. Rancho Bernardo, California A total of 393 community‐dwelling women aged 55 to 89 years who were not using replacement estrogen. Between 1984 and 1987, sera were collected for measurement of total and bioavailable testosterone, total and bioavailable estradiol, and estrone Between 1988 and 1991, 12 standard neuropsychological tests were administered, including two items from the Blessed Information‐Memory‐Concentration Test, three measures of retrieval from the Buschke‐Fuld Selective Reminding Test, a category fluency test, immediate and delayed recall from the Visual Reproduction Test, the Mini‐Mental State Examination (MMSE) with individual analysis of the Serial 7's and the “World” Backwards components, and the Trail‐Making Test part B (Trails B). The association between the five hormones and the 12 cognitive function tests was tested in age‐ and education‐adjusted analyses using linear regression, partial correlation, quintile and categorical analyses. Women with better MMSE scores (〉23) had significantly higher adjusted mean total and bioavailability testosterone levels (P = .009; P = .02, respectively). Using linear regression, the mean total testosterone was significantly associated with better performance on the World component of the MMSE (b = .12; P = .08). With regard to estrogen, the only statistically significant (P = .02) association was better performance on one test in women with very low levels of estuarial. In these older women, higher endogenous estrogen levels were not associated with significantly better performance on any cognitive function test. In contrast, higher levels of testosterone predicted better categorical performance on the MMSE and the World component of the MMSE. These novel findings warrant further research. J Am Geriatr Soc 47:1289–1293, 1999.
    Keywords: Aged ; Hormones ; Memory ; Women
    ISSN: 0002-8614
    E-ISSN: 1532-5415
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  • 3
    Language: English
    In: Analytical Biochemistry, August 1999, Vol.273(1), pp.133-141
    Description: The binding of the Fab fragment of monoclonal antibody NC10 to influenza virus N9 neuraminidase, isolated from tern and whale, was measured using an optical biosensor. Both neuraminidases, homotetramers of 190 kDa, were immobilized to avoid multivalent binding, and the binding of the monovalent NC10 Fab to immobilized neuraminidase was analyzed using the 1:1 Langmuir binding model. A contribution of mass transport to the kinetic constants was demonstrated at higher surface densities and low flow rates, and was minimized at low ligand densities and relatively high flow rates (up to 100 l/min). Application of a global fitting algorithm to a 1:1 binding model incorporating a correction term for mass transport indicated that mass transport was minimized under appropriate experimental conditions; analysis of binding data with a mass transport component, using this model, yielded kinetic constants similar to those obtained with the 1:1 Langmuir binding model applied to binding data where mass transport had been minimized experimentally. The binding constant for binding of NC10 Fab to N9 neuraminidase from tern influenza virus (KA = 6.3 ± 1.3 × 107 M-1) was about 15-fold higher than that for the NC10 Fab binding to N9 neuraminidase from whale influenza virus (KA = 4.3 ± 0.7 × 106 M-1). This difference in binding affinity was mainly attributable to a 12-fold faster dissociation rate constant of the whale neuraminidase-NC10 Fab complex and may be due to either (i) the long-range structural effects caused by mutation of two residues distant from the binding epitope or (ii) differences in carbohydrate residues, attached to Asn200, which form part of the binding epitope on both neuraminidases to which NC10 Fab binds. Copyright 1999 Academic Press.
    Keywords: Serum
    ISSN: 0003-2697
    E-ISSN: 10960309
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  • 4
    Language: English
    In: Journal of the American Academy of Child and Adolescent Psychiatry, October 1999, Vol.38(10), pp.1316-9
    Keywords: Child Development ; Cloning, Molecular -- Methods ; Mental Disorders -- Genetics
    ISSN: 0890-8567
    E-ISSN: 15275418
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  • 5
    Language: English
    In: Science, 17 December 1999, Vol.286(5448), pp.2319-2322
    Description: Interstellar dust grains intercepted by the dust detectors on the Ulysses and Galileo spacecrafts at heliocentric distances from 2 to 4 astronomical units show a deficit of grains with masses from 1 × 10$^{-17}$ to 3 × 10$^{-16}$ kilograms relative to grains intercepted outside 4 astronomical units. To divert grains out of the 2- to 4-astronomical unit region, the solar radiation pressure must be 1.4 to 1.8 times the force of solar gravity. These figures are consistent with the optical properties of spherical or elongated grains that consist of astronomical silicates or organic refractory material. Pure graphite grains with diameters of 0.2 to 0.4 micrometer experience a solar radiation pressure force as much as twice the force of solar gravity.
    Keywords: Grains ; Dust ; Interstellar ; Solar Radiation ; Astronomical Bodies ; Gravitation ; Deflection ; Galileo Spacecraft ; Miscellaneous Sciences (So) ; Article;
    ISSN: 00368075
    E-ISSN: 10959203
    Source: Archival Journals (JSTOR)
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  • 6
    Language: English
    In: Science (New York, N.Y.), 17 December 1999, Vol.286(5448), pp.2319-22
    Description: Interstellar dust grains intercepted by the dust detectors on the Ulysses and Galileo spacecrafts at heliocentric distances from 2 to 4 astronomical units show a deficit of grains with masses from 1 x 10(-17) to 3 x 10(-16) kilograms relative to grains intercepted outside 4 astronomical units. To divert grains out of the 2- to 4-astronomical unit region, the solar radiation pressure must be 1.4 to 1.8 times the force of solar gravity. These figures are consistent with the optical properties of spherical or elongated grains that consist of astronomical silicates or organic refractory material. Pure graphite grains with diameters of 0.2 to 0.4 micrometer experience a solar radiation pressure force as much as twice the force of solar gravity.
    Keywords: Cosmic Dust
    ISSN: 0036-8075
    E-ISSN: 10959203
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  • 7
    In: Nature, 1999, Vol.399(6736), p.558
    ISSN: 0028-0836
    Source: Nature Publishing Group
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  • 8
    Language: English
    In: Journal of Molecular Biology, 26 February 1999, Vol.286(3), pp.933-949
    Description: The myosin filaments of striated muscle contain a family of enigmatic myosin-binding proteins (MyBP), MyBP-C and MyBP-H. These modular proteins of the intracellular immunoglobulin superfamily contain unique domains near their N termini. The N-terminal domain of cardiac MyBP-C, the MyBP-C motif, contains additional phosphorylation sites and may regulate contraction in a phosphorylation dependent way. In contrast to the C terminus, which binds to the light meromyosin portion of the myosin rod, the interactions of this domain are unknown. We demonstrate that fragments of MyBP-C containing the MyBP-C motif localise to the sarcomeric A-band in cardiomyocytes and isolated myofibrils, without affecting sarcomere structure. The binding site for the MyBP-C motif resides in the N-terminal 126 residues of the S2 segment of the myosin rod. In this region, several mutations in β-myosin are associated with FHC; however, their molecular implications remained unclear. We show that two representative FHC mutations in β-myosin S2, R870H and E924K, drastically reduce MyBP-C binding ( K d ≈60 μM for R870H compared with a K d of≈5 μM for the wild-type) down to undetectable levels (E924K). These mutations do not affect the coiled-coil structure of myosin. We suggest that the regulatory function of MyBP-C is mediated by the interaction with S2, and that mutations in β-myosin S2 may act by altering the interactions with MyBP-C.
    Keywords: Myosin ; Myosin-Binding Protein-C ; Coiled-Coil ; Hypertrophic Cardiomyopathy ; Biology ; Chemistry
    ISSN: 0022-2836
    E-ISSN: 1089-8638
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  • 9
    Language: English
    In: Journal of molecular biology, 26 February 1999, Vol.286(3), pp.933-49
    Description: The myosin filaments of striated muscle contain a family of enigmatic myosin-binding proteins (MyBP), MyBP-C and MyBP-H. These modular proteins of the intracellular immunoglobulin superfamily contain unique domains near their N termini. The N-terminal domain of cardiac MyBP-C, the MyBP-C motif, contains additional phosphorylation sites and may regulate contraction in a phosphorylation dependent way. In contrast to the C terminus, which binds to the light meromyosin portion of the myosin rod, the interactions of this domain are unknown. We demonstrate that fragments of MyBP-C containing the MyBP-C motif localise to the sarcomeric A-band in cardiomyocytes and isolated myofibrils, without affecting sarcomere structure. The binding site for the MyBP-C motif resides in the N-terminal 126 residues of the S2 segment of the myosin rod. In this region, several mutations in beta-myosin are associated with FHC; however, their molecular implications remained unclear. We show that two representative FHC mutations in beta-myosin S2, R870H and E924K, drastically reduce MyBP-C binding (Kd approximately 60 microM for R870H compared with a Kd of approximately 5 microM for the wild-type) down to undetectable levels (E924K). These mutations do not affect the coiled-coil structure of myosin. We suggest that the regulatory function of MyBP-C is mediated by the interaction with S2, and that mutations in beta-myosin S2 may act by altering the interactions with MyBP-C.
    Keywords: Cardiomyopathy, Hypertrophic -- Genetics ; Carrier Proteins -- Metabolism ; Mutation -- Genetics ; Myosins -- Genetics
    ISSN: 0022-2836
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  • 10
    In: Economic Record, Vol. 75, No. 231, 1999: 385-396
    Keywords: Import Entitlements ; Duty Remission Schemes ; Export Processing Zones ; Dismantling Trade Barriers ; Extended Duty Drawback ; World Trade Organization ; Multilateral Negotiations ; Concessional Trade Instruments ; Intra-Industry Trade Expansion ; Asia: Economic Policy ; International Commerce ; Developing Countries ; International Organisations ; Negotiation ; Tariffs
    ISSN: 0013-0249
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