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  • 2001  (32)
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  • 2001  (32)
  • 1
    In: Cell, May 18, 2001, Vol.105(4), p.533(14)
    Description: Research has been conducted on the beta-catenin, an important molecule in Wnt/wingless signaling which controls steps in embryogenesis. The role of beta-catenin in skin development has been investigated via the conditional mutation of the epidermis and hair follicle gene and the results indicate that beta-catenin mutation has blocked placode formation which generates hair follicles.
    Keywords: Cytological Research -- Analysis ; Morphogenesis -- Physiological Aspects ; Stem Cells -- Physiological Aspects ; Hair Follicles -- Genetic Aspects ; Gene Mutation -- Physiological Aspects ; Epidermis -- Genetic Aspects
    ISSN: 0092-8674
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  • 2
    Language: English
    In: Current Biology, 26 June 2001, Vol.11(12), pp.941-950
    Description: BACKGROUND: Small, untranslated RNA molecules were identified initially in bacteria, but examples can be found in all kingdoms of life. These RNAs carry out diverse functions, and many of them are regulators of gene expression. Genes encoding small, untranslated RNAs are difficult to detect experimentally or to predict by traditional sequence analysis approaches. Thus, in spite of the rising recognition that such RNAs may play key roles in bacterial physiology, many of the small RNAs known to date were discovered fortuitously.RESULTS: To search the Escherichia coli genome sequence for genes encoding small RNAs, we developed a computational strategy employing transcription signals and genomic features of the known small RNA-encoding genes. The search, for which we used rather restrictive criteria, has led to the prediction of 24 putative sRNA-encoding genes, of which 23 were tested experimentally. Here we report on the discovery of 14 genes encoding novel small RNAs in E. coli and their expression patterns under a variety of physiological conditions. Most of the newly discovered RNAs are abundant. Interestingly, the expression level of a significant number of these RNAs increases upon entry into stationary phase.CONCLUSIONS: Based on our results, we conclude that small RNAs are much more widespread than previously imagined and that these versatile molecules may play important roles in the fine-tuning of cell responses to changing environments.
    Keywords: Biology
    ISSN: 0960-9822
    E-ISSN: 1879-0445
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  • 3
    In: RNA, 2/2001, Vol.7(2), pp.285-292
    Description: Higher plant chloroplasts provide the only experimentally validated example of functional tRNA genes that are disrupted by group II introns. Here, precursor transcripts for tRNA(Gly)(UCC), tRNA(Val)(UAC), and tRNA(Ala)(UGC) were investigated for processing of 5' leader and 3' trailer sequences in vivo. Use of intron-specific primer pairs and inclusion of a barley chloroplast splicing mutant specifically allowed us to evaluate the potential effect of intervening sequences that disrupt tRNA secondary and tertiary structures. The data suggest that (1) neither integrity of the dihydrouridine nor the anticodon domain is required for the nucleotidyltransferase-mediated addition of 3'-terminal CCA; (2) interruption of these two structural elements by group II introns does not interfere with nucleotide-specific 5' maturation by RNase P; (3) processing intermediates of chloroplast tRNAs can be 3' polyadenylated; and (4) plastid DNA-encoded proteins are not required for 3' and 5' maturation of plastid tRNAs.
    Keywords: Biology ; Chemistry ; Anatomy & Physiology;
    ISSN: 13558382
    E-ISSN: 14699001
    Source: CrossRef
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  • 4
    Description: In 1977, Young proposed a voting scheme that extends the Condorcet Principle based on the fewest possible number of voters whose removal yields a Condorcet winner. We prove that both the winner and the ranking problem for Young elections is complete for the class of problems solvable in polynomial time by parallel access to NP. Analogous results for Lewis Carroll's 1876 voting scheme were recently established by Hemaspaandra et al. In contrast, we prove that the winner and ranking problems in Fishburn's homogeneous variant of Carroll's voting scheme can be solved efficiently by linear programming. Comment: 10 pages
    Keywords: Computer Science - Computational Complexity ; F.1.3 ; F.2.2 ; J.4
    Source: Cornell University
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  • 5
    Book
    Book
    Chichester, UK: John Wiley & Sons, Ltd
    Language: English
    Description: Since the publication of the first edition the number of GSM subscribers has exploded and it is now deployed in more than 140 countries worldwide. Revised and updated "GSM Switching, Services, and Protocols" now features the abundant new services and applications that GSM can provide. By focusing on the fundamentals of the mobile radio systems, it provides an excellent introductory insight to the whole area of GSM cellular radio. By providing an easy-to-follow instructive text, this second edition will have insight appeal to telecommunication engineers, researchers, adn developers. The highly graphical approach and numerous illustrations will also make it an indispensable reference for senior undergraduates and postgraduates in electrical and computer engineering. It details the GSM phase 2+ services, including new data and speech services and service platforms, such as AMR, ASCI, CAMEL and EFR. -- This work: features a brand new chapter on General Packet Radio Service (GPRS) -- contains a completely revised and expanded chapter 'GSM - The story goes on' -- presents new sections on Wireless Application Protocol (WAP) and the migration to UMTS -- and includes expanded and updated chapters on Logical Channels and Channel Coding..
    Keywords: Global system for mobile communications; Mobile communication systems; Wireless communication systems;
    ISBN: 9780471499039
    ISBN: 047149903X
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  • 6
    Book chapter
    Book chapter
    Chichester, UK: John Wiley & Sons, Ltd
    Language: English
    In: GSM Switching, Services and Protocols, Chapter app3, p.313-320
    ISBN: 9780471499039
    Source: John Wiley & Sons, Inc.
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  • 7
    Book chapter
    Book chapter
    Chichester, UK: John Wiley & Sons, Ltd
    Language: English
    In: GSM Switching, Services and Protocols, Chapter app2, p.311-312
    ISBN: 9780471499039
    Source: John Wiley & Sons, Inc.
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  • 8
    Book chapter
    Book chapter
    Chichester, UK: John Wiley & Sons, Ltd
    Language: English
    In: GSM Switching, Services and Protocols, Chapter app1, p.301-310
    ISBN: 9780471499039
    Source: John Wiley & Sons, Inc.
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  • 9
    Book chapter
    Book chapter
    Chichester, UK: John Wiley & Sons, Ltd
    Language: English
    In: GSM Switching, Services and Protocols, Chapter fmatter_indsub, p.i-xiv
    Description: the prelims comprise: half‐title page title page copyright page contents preface for second edition preface index
    ISBN: 9780471499039
    Source: John Wiley & Sons, Inc.
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  • 10
    Book chapter
    Book chapter
    Chichester, UK: John Wiley & Sons, Ltd
    Language: English
    In: GSM Switching, Services and Protocols, Chapter refs, p.297-300
    ISBN: 9780471499039
    Source: John Wiley & Sons, Inc.
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