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  • 1
    Language: German
    Description: Band 1 dieses zweibändigen Lehrbuchs erarbeitet die Grundlagen einer Didaktik für den Unterricht mit blinden und hochgradig sehbehinderten Schülerinnen und Schülern. Band 2 liefert die Ausdifferenzierung in Fachdidaktiken und fächerübergreifende Bildungsanliegen. Thematisiert werden hierbei folgende Unterrichtsbereiche: Lesen und Schreiben; Mathematisches Lernen; Veranschaulichung in historischen, geografischen und naturwissenschaftlichen Kontexten; Musik; Bewegungserziehung; Kunst und Gestalten; Informationstechnologie; Selbst- und Sozialkompetenzen. Die dargestellten Fachdidaktiken beziehen sich ausdrücklich auf Unterrichtssituationen in heterogenen Lerngruppen und schließen die Zielgruppe mehrfachbehinderter sehgeschädigter Schülerinnen und Schüler mit ein....
    Keywords: Behindertenpädagogik ; Sonderschulunterricht
    ISBN: 978-3-17-020151-4
    Source: DataCite
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  • 2
    Language: English
    In: Baltic journal of management, 2011, Vol.6(1), pp. 7-24
    Description: Purpose – The purpose of this paper is to provide an in-depth description of the process of institutionalisation and development of human resource management (HRM) practices in subsidiaries of German multinational companies in Russia. Design/methodology/approach – The study is based on nine case studies of Russian subsidiaries including 26 interviews (13 German expatriates and 13 local employees), participative observations and document analyses. The data analysis follows a qualitative methodology. Findings – The study provides four patterns of institutionalisation processes of HRM practices. They stress the importance of personal, institutional and contextual factors for the institutionalisation of HRM practices. Moreover, the key role of expatriates with their specific value orientations and behaviour in this process is highlighted. Research limitations/implications – One suggestion for further research would be to replicate the study quantitatively (in order to get more cases) as well as qualitatively (to get broader inter-cultural data). Furthermore, it would be valuable to take a more long-term focus to examine the described institutionalisation paths in the long run. Practical implications – The paper highlights the importance of personal characteristics of expatriates that are often underestimated in companies' selection procedures. Moreover, the connection between the parent company's strategy and the pattern of institutionalisation of HRM practices should make the company management reflect upon the preferred pattern before taking the basic decisions. Taking into account the strong economic relationship between Russia and Germany and the expected further development of joint activities, the paper provides also important insights for the use of German expatriates in Russia. Originality/value – This paper improves our comprehension of the complex process of implementation and institutionalisation of HRM practices abroad. Moreover, it contributes to the HRM literature as it employs the concept of “transnational spaces” as an alternative and additional approach to explain this process. The resulting patterns may not be restricted to the Russian case only but should be adaptable to other emerging countries as well.
    Keywords: Personalmanagement ; Multinationales Unternehmen ; Deutsch ; Auslandsaufenthalt ; Führungskräfte ; Russland
    ISSN: 17465265
    E-ISSN: 17465273
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  • 3
    Language: English
    In: International Journal of Oncology, August 2011, Vol.39(2), pp.515-520
    Description: We performed this study in order to evaluate the impact of the chemokine CXCL12 and its single-nucleotide polymorphism (SNP) rs1801157 on clinicopathological parameters and survival in patients undergoing surgery for esophagogastric cancer. The expression pattern of CXCL12 and its polymorphisms were analyzed by RT-PCR and PCR-RFLP in 69 consecutive fresh-frozen samples of human esophagogastric junction and gastric adenocarcinomas and statistically analyzed. Expression of the CXCL12 (SNP rs1801157) polymorphisms GA/AA significantly correlated with distant metastasis (P=0.026), but not with prognosis. However, CXCL12 expression was not significantly associated with the tumor infiltration depth, lymphatic metastasis and grading. As CXCL12 polymorphisms mediate tumor cell dissemination in esophagogastric cancer, they could represent a marker indicating advanced disease. Antagonists targeting the CXCL12/ CXCR4 axis may be a novel therapeutic option in this entity.
    Keywords: Medicine;
    ISSN: 1019-6439
    E-ISSN: 17912423
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  • 4
    Language: English
    In: World Journal of Surgery, 2011, Vol.35(5), pp.1010-1016
    Description: BACKGROUNDThe present study was designed to evaluate the impact of the tyrosine kinase ligands VEGF-A/C/D, PDGF-A/B on tumor dissemination and survival in gastric cancer. This is the first study analyzing all these parameters in a homogeneous patient population undergoing surgery. METHODSThe expression pattern of VEGF-A/C/D and PDGF-A/B was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) in 69 samples of human gastric adenocarcinoma and correlated with tumor stage and survival. RESULTSExpression of the ligand VEGF-D significantly correlated with distant metastatic disease (P=0.00001) but not with patient survival. However, VEGF-A inversely correlated with M1 and grading, PDGF-A inversely correlated with pT and pN category. In contrast, VEGF-C and PDGF-B did not have an impact on clinicopathological parameters. CONCLUSIONSThe ligand VEGF-D, rather than the other ligands or tyrosine kinase receptors analyzed, is associated with progressive disease in gastric cancer patients undergoing surgery. The VEGF-D ligand might be a helpful marker indicating disseminated disease, and targeting VEGF-D may be a potential therapeutic strategy, although limitations imposed by the selected sample population have to be considered critically.
    Keywords: Adenocarcinoma–Mortality ; Adult–Pathology ; Aged–Surgery ; Aged, 80 and Over–Metabolism ; Female–Mortality ; Humans–Pathology ; Immunohistochemistry–Surgery ; Male–Metabolism ; Middle Aged–Metabolism ; Neoplasm Metastasis–Metabolism ; Platelet-Derived Growth Factor–Metabolism ; Reverse Transcriptase Polymerase Chain Reaction–Metabolism ; Stomach Neoplasms–Metabolism ; Vascular Endothelial Growth Factor A–Metabolism ; Vascular Endothelial Growth Factor C–Metabolism ; Vascular Endothelial Growth Factor D–Metabolism ; Platelet-Derived Growth Factor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor C ; Vascular Endothelial Growth Factor D;
    ISSN: 0364-2313
    E-ISSN: 1432-2323
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