Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2019  (7)
Type of Medium
Language
Year
  • 2019  (7)
  • 1
    Language: English
    In: Bulletin of the Seismological Society of America, 04/2019, Vol.109(2), pp.575-585
    Description: Typical ground-motion prediction equations (GMPEs) do not account for systematic path effects, which leads to an overestimation of aleatory variability. We provide an update to the Californian GMPE model of Abrahamson et al. (2014) that explicitly accounts for path effects in California by replacing the anelastic attenuation coefficient with a regionally varying one. The updated attenuation model is based on the approach of Dawood and Rodriguez-Marek (2013). Accounting for path effects leads to a smaller value of the aleatory variability, and results in different median predictions, depending on source and site location. The model is cast as a Bayesian hierarchical model, which allows one to capture the epistemic uncertainties in the anelastic attenuation coefficients. We show that it is important to account for the uncertainty in the attenuation coefficients when using the model for prediction. The differences in attenuation decrease with increasing spectral period. The updated attenuation model is developed with respect to the GMPE of Abrahamson et al. (2014) but can be easily extended for other models and other regions as well.
    Keywords: Seismology ; Acceleration ; Attenuation ; Bayesian Analysis ; California ; Earthquake Prediction ; Earthquakes ; Geologic Hazards ; Ground Motion ; Mathematical Models ; Natural Hazards ; Nga-West2 ; Peak Ground Acceleration ; Statistical Analysis ; United States;
    ISSN: 0037-1106
    E-ISSN: 1943-3573
    Source: CrossRef
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: International Journal of Cancer, 01 August 2019, Vol.145(3), pp.857-868
    Description: We analyzed the predictive potential of pretreatment soluble carbonic anhydrase IX levels (sCAIX) for the efficacy of bevacizumab in the phase III neoadjuvant GeparQuinto trial. sCAIX was determined by enzyme‐linked immunosorbent assay (ELISA). Correlations between sCAIX and pathological complete response (pCR), disease‐free and overall survival (DFS, OS) were assessed with logistic and Cox proportional hazard regression models using bootstrapping for robust estimates and internal validation. 1,160 HER2‐negative patient sera were analyzed, of whom 577 received bevacizumab. Patients with low pretreatment sCAIX had decreased pCR rates (12.1 . 20.1%,  = 0.012) and poorer DFS (adjusted 5‐year DFS 71.4 . 80.5 months,  = 0.010) compared to patients with high sCAIX when treated with neoadjuvant chemotherapy (NCT). For patients with low sCAIX, pCR rates significantly improved upon addition of bevacizumab to NCT (12.1 . 20.4%;  = 0.017), which was not the case in patients with high sCAIX (20.1% for NCT . 17.0% for NCT‐B,  = 0.913). When analyzing DFS we found that bevacizumab improved 5‐year DFS for patients with low sCAIX numerically but not significantly (71.4 . 78.5 months; log rank 0.234). In contrast, addition of bevacizumab worsened 5‐year DFS for patients with high sCAIX (81 . 73.6 months, log‐rank 0.025). By assessing sCAIX levels we identified a patient cohort in breast cancer that is potentially undertreated with NCT alone. Bevacizumab improved pCR rates in this group, suggesting sCAIX is a predictive biomarker for bevacizumab with regards to treatment response. Our data also show that bevacizumab is not beneficial in patients with high sCAIX. What's new? While the addition of bevacizumab to neoadjuvant therapy can improve rates of pathological complete response (pCR) in different malignancies, a biomarker to identify patients likely to benefit from the combined therapy is lacking. In this study, serum soluble carbonic anhydrase IX (sCAIX) was identified as a marker for the selection of patients with early breast cancer responding to combined bevacizumab and neoadjuvant chemotherapy. Significant improvements in pCR rates were observed in patients with low sCAIX levels. The addition of bevacizumab further improved 5‐year disease‐free survival in low sCAIX patients, while having detrimental effects in patients with high sCAIX levels.
    Keywords: Breast Cancer ; Carbonic Anhydrase Ix ; Predictive Biomarker ; Bevacizumab ; Neoadjuvant Treatment
    ISSN: 0020-7136
    E-ISSN: 1097-0215
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Psychotherapy, 2019, Vol.56(1), pp.21-27
    Description: The pretreatment phase in dialectical behavior therapy (DBT) sets the critical foundation for working with multiproblem, often highly suicidal clients. Despite the importance of this stage of treatment, very little has been written to aid DBT clinicians in navigating these early sessions most effectively. This article describes the functions and goals of pretreatment in DBT and research relevant to strategies employed in pretreatment. Additionally, a case example of a pretreatment session in DBT is provided, and challenges commonly encountered in pretreatment are discussed, along with recommendations for overcoming those challenges. ; Question: What are the functions and goals of the pretreatment phase in dialectical behavior therapy (DBT), and how can therapists navigate pretreatment most effectively? Findings: No novel research findings are presented, but the recommendations and case example provided may prove useful to clinicians working to overcome the challenges of pretreatment in DBT. Meaning: DBT pretreatment strategies appear to promote goal identification and client commitment. Next Steps: More research is needed to determine which strategies in DBT’s pretreatment sessions uniquely contribute to positive treatment outcomes.
    Keywords: Suicide ; Dbt ; Psychological Treatment ; Evidence-Based Treatment
    ISSN: 0033-3204
    E-ISSN: 1939-1536
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Earth and Planetary Science Letters, 01 July 2019, Vol.517, pp.135-147
    Description: The current understanding of tsunamis generated by volcanic-island landslides is reliant on numerical models benchmarked against reconstructions of past events. As the largest historical event with timed tsunami observations, the 1888 sector collapse of Ritter Island, Papua New Guinea provides an outstanding opportunity to better understand the linked process of landslide emplacement and tsunami generation. Here, we use a combination of geophysical imaging, bathymetric mapping, seafloor observations and sampling to demonstrate that the Ritter landslide deposits are spatially and stratigraphically heterogeneous, reflecting a complex evolution of mass-flow processes. The primary landslide mass was dominated by well-bedded scoriaceous deposits, which rapidly disintegrated to form an erosive volcaniclastic flow that incised the substrate over much of its pathway. The major proportion of this initial flow is inferred to have been deposited up to 80 km from Ritter. The initial flow was followed by secondary failure of seafloor sediment, over 40 km from Ritter. The most distal part of the 1888 deposit has parallel internal boundaries, suggesting that multiple discrete units were deposited by a series of mass-flow processes initiated by the primary collapse. The last of these flows was derived from a submarine eruption triggered by the collapse. This syn-collapse eruption deposit is compositionally distinct from pre- and post-collapse eruptive products, suggesting that the collapse immediately destabilised the underlying magma reservoir. Subsequent eruptions have been fed by a modified plumbing system, constructing a submarine volcanic cone within the collapse scar through at least six post-collapse eruptions. Our results show that the initial tsunami-generating landslide at Ritter generated a stratigraphically complex set of deposits with a total volume that is several times larger than the initial failure. Given the potential for such complexity, there is no simple relationship between the volume of the tsunamigenic phase of a volcanic-island landslide and the final deposit volume, and deposit area or run-out cannot be used to infer primary landslide magnitude. The tsunamigenic potential of prehistoric sector-collapse deposits cannot, therefore, be assessed simply from surface mapping, but requires internal geophysical imaging and direct sampling to reconstruct the event.
    Keywords: Sector Collapse ; Volcanic Island ; Tsunami ; Landslide ; Ritter Island ; Papua New Guinea ; Geology ; Physics
    ISSN: 0012-821X
    E-ISSN: 1385-013X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Earth and Planetary Science Letters, 01 July 2019, Vol.517, pp.1-13
    Description: Volcanic island flank collapses have the potential to trigger devastating tsunamis threatening coastal communities and infrastructure. The 1888 sector collapse of Ritter Island, Papua New Guinea (in the following called Ritter) is the most voluminous volcanic island flank collapse in historic times. The associated tsunami had run-up heights of more than 20 m on the neighboring islands and reached settlements 600 km away from its source. This event provides an opportunity to advance our understanding of volcanic landslide-tsunami hazards. Here, we present a detailed reconstruction of the 1888 Ritter sector collapse based on high-resolution 2D and 3D seismic and bathymetric data covering the failed volcanic edifice and the associated mass-movement deposits. The 3D seismic data reveal that the catastrophic collapse of Ritter occurred in two phases: (1) Ritter was first affected by deep-seated, gradual spreading over a long time period, which is manifest in pronounced compressional deformation within the volcanic edifice and the adjacent seafloor sediments. A scoria cone at the foot of Ritter acted as a buttress, influencing the displacement and deformation of the western flank of the volcano and causing shearing within the volcanic edifice. (2) During the final, catastrophic phase of the collapse, about 2.4 km of Ritter disintegrated almost entirely and traveled as a highly energetic mass flow, which incised the underlying sediment. The irregular topography west of Ritter is a product of both compressional deformation and erosion. A crater-like depression underlying the recent volcanic cone and eyewitness accounts suggest that an explosion may have accompanied the catastrophic collapse. Our findings demonstrate that volcanic sector collapses may transform from slow gravitational deformation to catastrophic collapse. Understanding the processes involved in such a transformation is crucial for assessing the hazard potential of other volcanoes with slowly deforming flanks such as Mt. Etna or Kilauea.
    Keywords: Volcanic Sector Collapse ; Ritter Island ; Landslide ; Tsunami ; 3d Seismic Interpretation ; Geology ; Physics
    ISSN: 0012-821X
    E-ISSN: 1385-013X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: The Journal of experimental medicine, 02 September 2019, Vol.216(9), pp.1986-1998
    Description: IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and is targeted in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by We describe two patients with homozygous mutations in who presented with recurrent infections, abnormal acute-phase responses,...
    Keywords: Research Articles ; 310;
    ISSN: 00221007
    E-ISSN: 1540-9538
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    Description: : IL-6 excess is central to the pathogenesis of multiple inflammatory conditions and this is targeted in clinical practice by immunotherapy that blocks the IL-6 receptor encoded by IL6R. We describe two patients with homozygous mutations in IL6R who presented with recurrent infections, abnormal...
    Description: J.E.D.T. is supported by the MRC (RG95376 and MR/L006197/1). KB is supported by the European Research Council (ERC StG 310857) and the Austrian Science Fund (P29951-B30). This work is supported, in part, by the intramural research program of the NIAID, NIH. A.J.T. is supported by the Wellcome Trust (104807/Z/14/Z)...
    Source: DSpace@Cambridge
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages