Lipids, 2016, Vol.51(3), pp.357-357
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s11745-016-4123-3 Byline: Mehri Jamilian (1), Maryam Karamali (2), Mohsen Taghizadeh (3), Nasrin Sharifi (3), Zahra Jafari (3), Mohammad Reza Memarzadeh (4), Mahnaz Mahlouji (4), Zatolla Asemi (3) Keywords: Vitamin D; Evening primrose oil; Supplementation; Gestational diabetes Abstract: Limited data are available assessing the effects of vitamin D and evening primrose oil (EPO) administration on markers of insulin resistance and lipid concentrations in gestational diabetes mellitus (GDM). This study was designed to evaluate the effects of vitamin D and EPO administration on insulin resistance and lipid concentrations among women with GDM. In this prospective randomized, double-blind, placebo-controlled clinical trial, 60 participants with GDM were divided into 2 groups of either 1000 IU vitamin D3 and 1000 mg EPO or placebo for 6 weeks. At the beginning and end of the study, fasting blood samples were obtained from the participants to measure related variables. After 6 weeks of intervention, changes in fasting plasma glucose (-3.6 [+ or -] 7.5 vs. +1.5 [+ or -] 11.4 mg/dL, P = 0.04), serum insulin concentrations (-2.0 [+ or -] 5.3 vs. +4.6 [+ or -] 10.7 A[micro]IU/mL, P = 0.004), homeostasis model of assessment (HOMA) insulin resistance (-0.5 [+ or -] 1.1 vs. +1.1 [+ or -] 2.5, P = 0.003), HOMA-B cell function (-7.7 [+ or -] 23.3 vs. +17.4 [+ or -] 42.9, P = 0.007) and the quantitative insulin sensitivity check index (+0.01 [+ or -] 0.02 vs. -0.01 [+ or -] 0.02, P = 0.007) in the vitamin D plus EPO group were significantly different from the placebo group. In addition, compared with the placebo, vitamin D and EPO supplementation resulted in significant reductions in serum TAG (-20.0 [+ or -] 54.3 vs. +34.3 [+ or -] 38.2 mg/dL, P 〈 0.001), VLDL (-4.0 [+ or -] 10.9 vs. +6.9 [+ or -] 7.6 mg/dL, P 〈 0.001), TC (-22.1 [+ or -] 32.6 vs. +5.3 [+ or -] 20.1 mg/dL, P 〈 0.001), LDL concentrations (-18.0 [+ or -] 25.5 vs. +1.8 [+ or -] 15.7 mg/dL, P = 0.001) and TC/HDL (-0.3 [+ or -] 0.4 vs. +0.3 [+ or -] 0.5 mg/dL, P 〈 0.001). We did not observe any significant effect of vitamin D and EPO supplementation on serum HDL concentrations. Clinical trial registration number: http://www.irct.ir : IRCT201509115623N52. Author Affiliation: (1) Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Islamic Republic of Iran (2) Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran (3) Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, PO Box 8715988141, Kashan, Islamic Republic of Iran (4) Barij Medicinal Plants Research Center, Kashan, Islamic Republic of Iran Article History: Registration Date: 05/01/2016 Received Date: 01/12/2015 Accepted Date: 24/12/2015 Online Date: 19/01/2016 Article note: An erratum to this article can be found at http://dx.doi.org/10.1007/s11745-016-4138-9.
Vitamin D – Analysis ; Pregnant Women – Diet Therapy ; Pregnant Women – Analysis ; Low Density Lipoproteins – Analysis ; Insulin Resistance – Diet Therapy ; Insulin Resistance – Analysis ; Glycoproteins – Analysis ; Gestational Diabetes – Diet Therapy ; Gestational Diabetes – Analysis ; Medical Schools – Analysis ; Glucose – Analysis;
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