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Berlin Brandenburg

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  • 1
    Language: English
    In: Neuropsychobiology, 1983, Vol.9(1), pp.9-12
    Description: Platelet recovery and activity of platelet monoamine oxidase (MAO) and plasma amine oxidase (PAO) were determined using different centrifugation procedures (125 g for 15 min vs. 600 g for 2.5 min) and anticoagulants. With either centrifugation procedure, the use of ethylenediaminetetraacetate (EDTA) as anticoagulant resulted in higher platelet yields and MAO activity compared to acid-citrate-dextrose (ACD). However, PAO activity was lower with EDTA as anticoagulant than with ACD. There was a trend toward higher platelet yields and higher activity levels of MAO and PAO with the 125 g centrifugation method than with the 600 g technique regardless of the anticoagulant used. The implications for MAO studies in psychiatric research were discussed.
    Keywords: Biological Psychiatry ; Platelet Monoamine Oxidase ; Plasma Amine Oxidase ; Centrifugation Procedures ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 2
    Language: English
    In: Journal of Affective Disorders, 1981, Vol.3(2), pp.167-171
    Description: Assortative mating was determined in 170 spouses of patients with major affective illness (bipolar and unipolar). An increase in affective disorders was found in both wives of affected men and husbands of affected women. The data suggest that assortative mating is present in the familial transmission of affective disorder.
    Keywords: Marriage ; Mood Disorders -- Genetics;
    ISSN: 0165-0327
    E-ISSN: 1573-2517
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  • 3
    Language: English
    In: Journal of Psychiatric Research, 1985, Vol.19(1), pp.9-21
    Description: Platelet monoamine oxidase (MAO) has been implicated in the biology of several psychiatric disorders, including schizophrenia. Genetic factors contribute to the variance of MAO activity; however, its mode of inheritance is unknown. To assess the distribution and familial patterns of platelet MAO activity, we studied 73 chronic schizophrenic patients and 219 of their first-degree relatives. The activity distribution was skewed and admixture of two distributions gave a better fit to the data than a single distribution. Single-major-locus hypotheses were tested by pedigree analysis methods for quantitative traits. Using the transmission probability model, the familial transmission of MAO activity was consistent with either recessive or additive inheritance but not with dominant inheritance; the environmental hypothesis was strongly rejected. No effect of genotype on probability of illness was observed suggesting no relationship between the particular major locus tested and schizophrenia. The implications for genetic research in schizophrenia were discussed.
    Keywords: Medicine
    ISSN: 0022-3956
    E-ISSN: 1879-1379
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  • 4
    Language: English
    In: Psychiatry Research, 1985, Vol.15(2), pp.121-132
    Description: Plasma amine oxidase (PAO) activity has been implicated in the biology of schizophrenia. PAO activity is, in part, under genetic control, but its mode of inheritance has not been determined. To assess the genetic pattern of PAO activity and its relation to the transmission of schizophrenia, we studied 73 chronic schizophrenia probands and 217 first-degree relatives (siblings and parents). Single-major-locus hypotheses were tested by pedigree analysis methods for quantitative traits. The distribution of PAO activity indicated significant admixture. When the transmission probability model was used, the familiar pattern of PAO activity was consistent with mendelian transmission; the environmental hypothesis was rejected. PAO activity was lower in schizophrenic patients than in unaffected relatives, but the mean reduction in enzyme activity was small (10.7%) and the two groups of subjects overlapped greatly in their PAO values. The difference between ill and well relatives was not statistically significant. However, schizophrenia spectrum disorders segregated with low PAO activity in families of low-activity probands, and a greater proportion of ill than well subjects clustered in the low PAO activity mode. The results are interpreted as follows: (1) The transmission of PAO activity may be determined in part by a single major autosomal gene. (2) Low PAO activity does not qualify as a major risk factor in the schizophrenic population at large; however, a relationship may exist between low PAO activity and the transmission of schizophrenia in families of patients with extremely low enzyme activity.
    Keywords: Schizophrenia ; Plasma Amine Oxidase ; Genetics ; Medicine
    ISSN: 0165-1781
    E-ISSN: 1872-7123
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  • 5
    Language: English
    In: Psychiatry Research, 1982, Vol.6(3), pp.345-353
    Description: Five sets of criteria for the diagnosis of schizophrenia were compared on 47 hospitalized patients who fit New York Research Diagnostic Criteria (RDC) for chronic schizophrenia. The other diagnostic systems used were the Flexible System. Feighner Criteria, New Haven Schizophrenia Index (NHSI), and Taylor-Abrams (TA) Criteria. The NSHI, the broadest system examined, fit all of the patients studied. In contrast, only 30 patients (63% of the sample) were diagnosed schizophrenic using TA Criteria. When the Strauss-Carpenter prognostic scale was used, patients who fit TA Criteria for schizophrenia did not differ in the prognostic scores from the remainder of the sample. In addition, the two groups did not differ in the familial rate of schizophrenia spectrum disorders. The usefulness of narrow versus broad diagnostic criteria in schizophrenia research is discussed.
    Keywords: Schizophrenia, Diagnostic Criteria, Prognosis, Family History ; Medicine
    ISSN: 0165-1781
    E-ISSN: 1872-7123
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  • 6
    Language: English
    In: Psychiatry Research, 1984, Vol.11(3), pp.205-209
    Description: Platelet monoamine oxidase activity (MAO) was determined in 39 unmedicated chronic schizophrenic patients and 88 normal control subjects. Platelet MAO activity did not distinguish paranoid from nonparanoid patients or patients who met Taylor and Abrams criteria for narrowly defined schizophrenia from other schizophrenics. Enzyme activity was not related to either prognostic scores or age at onset of illness. MAO activity was decreased in patients compared to controls, and was lower in males than in females. Our findings indicate that clinical phenomenology, as defined in the present study, is of limited use in identifying biological subtypes of schizophrenia with deviant platelet MAO activity.
    Keywords: Schizophrenia ; Platelet Monoamine Oxidase ; Clinical Phenomenology ; Medicine
    ISSN: 0165-1781
    E-ISSN: 1872-7123
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  • 7
    Language: English
    In: Neuropsychobiology, 1982, Vol.8(6), pp.312-314
    Description: Plasma dopamine-beta-hydroxylase (DBH) activity was determined in 8 chronic schizophrenic patients following neuroleptic treatment for 2 months. Enzyme activity was decreased by 13.7 ± 3.4% (mean ± SD). The difference from pre-drug levels was not statistically significant. The reduction in DBH activity stabilized after the 1 st month of treatment and was unrelated to neuroleptic drug load.
    Keywords: Paper ; Dopamine-Beta-Hydroxylase ; Neuroleptics ; Schizophrenia ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 8
    Language: English
    In: Neuropsychobiology, 1984, Vol.12(4), pp.206-208
    Description: The occurrence of stressful life events in relation to illness onset and family history of schizophrenia was assessed in 52 chronic schizophrenic patients. Severe or extreme premorbid stress was present in 15.4% of the patients. ‘Low stress’ patients were indistinguishable from ‘high stress’ patients with respect to the familial rate of schizophrenia and other ‘spectrum’ disorders.
    Keywords: Biological Psychiatry ; Family History ; Life Event ; Schizophrenia ; Onset ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 9
    Language: English
    In: Neuropsychobiology, 1988, Vol.19(1), pp.9-11
    Description: Using a cross-sectional design, we examined the diurnal and circannual variation in platelet 3H-imipramine binding in 33 patients with bipolar affective disorder, 34 patients with unipolar affective disorder and 58 normal controls. There was no evidence for statistically significant diurnal or circannual variation in the binding parameters in any of the diagnostic categories.
    Keywords: Biological Psychiatry ; Platelet 3h-Imipramine Binding ; Affective Disorder ; Diurnal and Seasonal Variation ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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  • 10
    Language: English
    In: Neuropsychobiology, 1987, Vol.17(4), pp.182-186
    Description: We studied platelet 3H-imipramine binding and family history of affective illness in 26 patients with bipolar affective disorder and 24 patients with unipolar affective disorder. The density of platelet 3H-imipramine binding sites (Bmax) was significantly lower in bipolar patients with family history of affective illness than in healthy controls; however, there was a considerable overlap in Bmax values between the familial cases and the normal controls. A similar trend was observed in familial cases of unipolar disorder but the differences fell short of statistical significance. The nonfamilial cases of affective disorder did not differ from the healthy controls. The possible role of reduced platelet 3H-imipramine binding as a genetic vulnerability ‘marker’ in affective disorder was discussed.
    Keywords: Biological Psychiatry ; Family History ; Platelet 3h-Imipramine Binding ; Affective Disorder ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology
    ISSN: 0302-282X
    E-ISSN: 1423-0224
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