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Berlin Brandenburg

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  • Berger, E.  (1,662)
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  • 1
    Article
    Article
    Language: English
    In: Annals of Emergency Medicine, 2014, Vol.63(6), pp.A19-A21
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2014.04.009 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Physicians
    ISSN: 0196-0644
    E-ISSN: 10976760
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  • 2
    Language: English
    In: Biochemical and Biophysical Research Communications, 17 June 2011, Vol.409(4), pp.610-615
    Description: ► TUDCA inhibits the expression of ER stress markers in intestinal epithelial cells. ► TUDCA prohibits the activation of the unfolded protein response in these cells. ► UDCA but not taurine mediates the inhibitory effects of TUDCA. ► The hydrophobic parts of TUDCA prohibit the aggregation of denatured proteins. Inflammatory bowel diseases (IBD) are chronically relapsing and immune-mediated disorders of the gastrointestinal tract. Endoplasmic reticulum (ER) stress mechanisms in the epithelium have been demonstrated to be implemented into the pathogenesis of intestinal inflammation. Chemical chaperones have been demonstrated to exhibit beneficial effects in various diseases associated with ER stress mechanisms by prohibiting the unfolded protein response (UPR). In a structure–function analysis, we tested the potential of the conjugated bile salt sodium tauroursodeoxycholate (TUDCA), naturally present in the small bowel, to resolve ER stress in intestinal epithelial cells. TUDCA efficiently inhibited the expression of UPR dependent genes like GRP78 triggered by the ER stressor tunicamycin in the small intestinal epithelial cell line Mode-K. TUDCA inhibited upstream signaling events in all three branches of the UPR cascade and diminished binding of UPR activated transcription factors to the promoter. A structure–function analysis revealed that UDCA but not its conjugation partner taurine, known as a chemical chaperone, is responsible for the inhibition of GRP78 induction and that UDCA is 10 times more effective than its taurine conjugate. This inhibitory effect was confirmed in a cell free assay, where TUDCA and UDCA but not taurine effectively inhibited the aggregation of thermally denatured BSA. We conclude that TUDCA and UDCA are potent anti-aggregants for the resolution of ER stress in intestinal epithelial cells and should be considered as a potential drug target to resolve ER stress mechanisms underlying the pathology of IBD.
    Keywords: Inflammatory Bowel Disease ; Endoplasmic Reticulum Stress ; Unfolded Protein Response ; Chemical Chaperone ; Tauroursodeoxycholic Acid ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
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  • 3
    In: Journal of Product Innovation Management, November 2013, Vol.30(6), pp.1199-1211
    Description: This study examines how information communications technologies (s) can be implemented effectively to provide financial service innovations to the poor who live in developing countries, a market collectively known as the “Base of the Pyramid” or . The needs—but commonly lacks—basic financial services, a situation that perpetuates poverty. With a dearth of formal banks especially in rural areas of developing countries, the has almost no access to savings accounts, credit lines, and other necessary services. However, s have the potential to overcome cost, infrastructure, and other barriers to service delivery, and are being used to offer new financial services such as mobile phone banking to the . The purpose of this study is to determine ways of successfully implementing these technology‐enabled service innovations. The study draws on the ocio‐echnical iew for theoretical girding, and uses case method to examine multiple implementation projects in five sub‐aharan frican countries (hana, enya, alawi, ozambique, and ganda). The projects, which were carried out by a leading microfinance banking organization named pportunity nternational, provided mobile banks, point‐of‐service, and mobile phone banking services to the . Several techniques were applied to gather data in the field over a two‐year period: depth interviews, direct observations, and internal document and data analysis. Multiple forms of evidence were triangulated against one another, and analyzed across cases until themes emerged and converged. In doing so, two specific forms of analysis, explanation building and cross‐case synthesis, were employed to make sense of the data. The findings, summarized as research propositions, collectively conclude that implementation is effective when the unique socio‐human, governmental‐regulatory, and market conditions of the are accounted for, such that fit is achieved between the technologies and environments they are situated in. More specifically, effectiveness comes when implementation (1) addresses customer and agent limits with the technologies, and is accepted and supported by trained staff who monitor technology use and make responsive system adjustments; (2) exploits and promotes supportive governmental regulations and actions, as well as leverages sound electronic fund transfer () switches, whether government or bank established; and (3) accounts for low business capabilities and evolving market competition, along with the underdeveloped financial sector and financial literacy of the population. In sum, there are multiple factors that should be considered in the design and installation activities surrounding these technologies to ensure they provide cost‐effective, quality financial services to the poor.
    Keywords: Electronic Funds Transfer Systems -- Innovations ; Developing Countries;
    ISSN: 0737-6782
    E-ISSN: 1540-5885
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  • 4
    Article
    Article
    Language: English
    In: Annals of Emergency Medicine, Nov, 2017, Vol.70(5), p.A15-A17
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2017.08.018 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    ISSN: 0196-0644
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  • 5
    Language: English
    In: Annals of Emergency Medicine, October 2017, Vol.70(4), pp.A17-A19
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2017.07.489 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Medicine
    ISSN: 0196-0644
    E-ISSN: 1097-6760
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  • 6
    Language: English
    In: Annals of Emergency Medicine, April 2017, Vol.69(4), pp.A20-A23
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2017.02.017 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Medicine
    ISSN: 0196-0644
    E-ISSN: 1097-6760
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  • 7
    Language: English
    In: Annals of Emergency Medicine, December 2015, Vol.66(6), pp.A20-A22
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2015.08.010 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Medicine
    ISSN: 0196-0644
    E-ISSN: 1097-6760
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  • 8
    Language: English
    In: Annals of Emergency Medicine, June 2017, Vol.69(6), pp.A15-A17
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2017.04.023 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Medicine
    ISSN: 0196-0644
    E-ISSN: 1097-6760
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  • 9
    Language: English
    In: Annals of Emergency Medicine, March 2017, Vol.69(3), pp.A17-A20
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2017.01.017 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Medicine
    ISSN: 0196-0644
    E-ISSN: 1097-6760
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  • 10
    Language: English
    In: Annals of Emergency Medicine, June 2015, Vol.65(6), pp.A11-A13
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.annemergmed.2015.04.019 Byline: Eric Berger Article Note: (footnote) Funding and support: By Annals policy, all authors are required to disclose any and all commercial, financial, and other relationships in any way related to the subject of this article as per ICMJE conflict of interest guidelines (see www.icmje.org). The author has stated that no such relationships exist., The views expressed in News and Perspective are those of the authors, and do not reflect the views and opinions of the American College of Emergency Physicians or the editorial board of Annals of Emergency Medicine.
    Keywords: Medicine
    ISSN: 0196-0644
    E-ISSN: 1097-6760
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