Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Bette, Stefanie  (17)
Type of Medium
Language
Year
  • 1
    In: Neuro-Oncology, 2017, Vol. 19(suppl6), pp.vi253-vi254
    Description: The potassium channel KIR4.1 (KCNJ10) and the glutamate catalyzing enzyme glutamine synthetase (GS) are highly expressed in glial cells of the central nervous system. Both glial proteins play important roles in the maintenance of neuronal activity and neurotransmission. Dysfunction of both proteins can result in altered neuronal excitability and may lead to excitotoxicity. We analyzed 35 snap frozen tissue blocks (glioblastoma [GBM], n=22; low grade astrocytoma (LGA), n=8; oligodendroglioma (OG), n=3; oligoastrocytoma, n=2). All glioma samples had a matching tissue specimen from both the tumor core and the adjacent normal-appearing infiltration zone. Molecular subtyping (MGMT, IDH1/2, 1p/19q) was available from tumor specimens. We combined conventional histology and immunohistochemistry with gene expression analysis and western blot. In preliminary analysis, we found downregulation of KIR4.1 and GS in the tumor core of GBM samples as compared to matching infiltration zone tissue of the same patients. In addition, KIR4.1 transcript levels were reduced in GBM core tissue as compared to LGA tumor core. The pan-astroglial protein AQP4 was not different between tumor core and infiltration zone. We observed a tendency that reduced GS transcript levels were associated with increased epileptic activity in GBM patients. In summary, we found that both KIR4.1 and GS were downregulated in tumor core versus infiltration zone tissue. Enhanced neuronal excitability and increased risk for epileptic activity might be associated with lack of KIR4.1 and GS activity.
    Keywords: Medicine;
    ISSN: 1522-8517
    E-ISSN: 1523-5866
    Source: Oxford University Press
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: World Neurosurgery, November 2016, Vol.95, pp.525-534.e1
    Description: Glioblastoma (GB) is an infiltrative disease that results in microstructural damage on a cellular level. Fractional anisotropy (FA) is an important estimate of diffusion tensor imaging (DTI) that can be used to assess microstructural integrity. The aim of this study was to examine the correlation between FA values and overall survival (OS) in patients with GB. This retrospective single-center study included 122 consecutive patients with GB (50 women; median age, 63 years) with preoperative MRI including fluid attenuated inversion recovery (FLAIR), contrast-enhanced T1-weighted sequences, and DTI. FA and apparent diffusion coefficient (ADC) values in contrast-enhancing lesions (FA-CEL, FA-ADC), nonenhancing lesions, and central tumor regions were correlated to histopathologic and clinical parameters. Univariate and multivariate survival analyses were performed. Patients with low FA-CEL (median 〈0.31) showed significantly improved OS in univariate analysis (  = 0.028). FA-CEL also showed a positive correlation with Ki-67 proliferation index (  = 0.003). However, in a multivariate survival model, FA values could not be identified as independent prognostic parameters beside established factors such as age and Karnofsky performance scale score. FA values in nonenhancing lesions and central tumor regions and mean ADC values had no distinct influence on OS. FA values can provide prognostic information regarding OS in patients with GB. There is a correlation between FA-CEL values and Ki-67 proliferation index, a marker for malignancy. Noninvasive identification of more aggressive GB growth patterns might be beneficial for preoperative risk evaluation and estimation of prognosis.
    Keywords: Dti ; Fractional Anisotropy ; Glioblastoma ; Outcome ; Survival
    ISSN: 1878-8750
    E-ISSN: 1878-8769
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: Neurosurgery, 2017, Vol.64(CN_suppl_1 Suppl 1), pp.292-293
    Description: Abstract Postoperative ischemia is a frequent phenomenon in patients with brain tumors and is associated with postoperative neurological deficits and impaired overall survival. Previous clinical and experimental studies have shown that the application of a brief ischemic stimulus not only in the target organ but also in a remote tissue can prevent ischemia. We hypothesized that remote ischemic preconditioning (rIPC) in patients with brain tumors undergoing elective surgical resection reduces the incidence of postoperative ischemic tissue damage and its consequences. Sixty patients were randomly assigned to two groups, with 1:1 allocation, stratified after tumor type (glioma or metastasis) and previous treatment with radiotherapy. Remote ischemic preconditioning was induced by inflating a blood pressure cuff placed on the upper arm three times for 5 minutes at 200 mmHg in the treatment group after induction of anesthesia. Between the cycles, the blood pressure cuff was released to allow reperfusion. In the control group no preconditioning was performed. Early postoperative MR images were evaluated blinded to randomization for the presence of ischemia and its volume. Fifty-eight of the 60 patients were assessed for occurrence of postoperative ischemia. Of these 58 patients, 44 (75.9%) had new postoperative ischemic lesions. The incidence of new postoperative ischemic lesions was significantly higher in the control group (87.1%) (27/31) than in the rIPC group (63.0%) (17/27) (P = 0.03). The median infarct volume was 0.36 cm3 (IR: 0.0- 2.35) in the rIPC group compared with 1.30 cm3 (IR: 0.29- 3.66) in the control group (P = 0.09). Application of rIPC significantly reduced the incidence of postoperative ischemic tissue damage in patients undergoing elective brain tumor surgery. This is the first study indicating a benefit of rIPC in brain tumor surgery.
    Keywords: Brain Cancer ; Tumors ; Ischemia;
    ISSN: 0148-396X
    E-ISSN: 15244040
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: BMC Medicine, 01 July 2017, Vol.15(1), pp.1-10
    Description: Abstract Background Postoperative ischemia is a frequent phenomenon in patients with brain tumors and is associated with postoperative neurological deficits and impaired overall survival. Particularly in the field of cardiac and vascular surgery,...
    Keywords: Ischemic Preconditioning ; Brain Tumor ; Glioma ; Brain Metastasis ; Neurooncology ; Neurosurgery ; Medicine
    E-ISSN: 1741-7015
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Sci Rep, 2017, Vol.7(1), pp.5585-5585
    Description: Aim of this study was to determine if perioperative hemodynamics have an impact on perioperative infarct volume and patients’ prognosis. 201 cases with surgery for a newly diagnosed or recurrent glioblastoma were retrospectively analyzed. Clinical data and perioperative hemodynamic parameters, blood tests and time of surgery were recorded. Postoperative infarct volume was quantitatively assessed by semiautomatic segmentation. Mean diastolic blood pressure (dBP) during surgery (rho −0.239, 95% CI −0.11 – −0.367, p = 0.017), liquid balance (rho 0.236, 95% CI 0.1–0.373, p = 0.017) and mean arterial pressure (MAP) during surgery (rho −0.206, 95% CI −0.07 – −0.34, p = 0.041) showed significant correlation to infarct volume. A rank regression model including also age and recurrent surgery as possible confounders revealed mean intraoperative dBP, liquid balance and length of surgery as independent factors for infarct volume. Univariate survival analysis showed mean intraoperative dBP and MAP as significant prognostic factors, length of surgery also remained as significant prognostic factor in a multivariate model. Perioperative close anesthesiologic monitoring of blood pressure and liquid balance is of high significance during brain tumor surgery and should be performed to prevent or minimize perioperative infarctions and to prolong survival.
    Keywords: Biology;
    ISSN: 2045-2322
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Oncotarget, 20 September 2016, Vol.7(38), pp.61945-61954
    Description: Postoperative ischemia is associated with reduced functional independence measured by karnofsky performance score (KPS), which correlates well with overall survival. Other studies suggest that postoperative hypoxia might initiate infiltrative tumor growth. Therefore, aim of this study was to analyze the impact of infarct volume on overall survival and progression free survival (PFS) of glioblastoma patients.251 patients with surgery for a newly diagnosed glioblastoma (WHO IV) were retrospectively assessed. Pre- and postoperative KPS, date of death/last follow-up and histopathological markers were recorded. Pre- and postoperative tumor volume and the volume of postoperative infarction were manually segmented.A significant correlation of infarct volume with postoperative KPS decrease (P = 0.001) was observed. Infarct volume showed a significant impact on overall survival (P = 0.014), but not on PFS (P = 0.112) in univariate analysis. This effect increased in the subgroup of patients with near-total tumor resection (〉 90%) (overall survival: P = 0.006, PFS: P = 0.066). Infarct volume remained as an independent prognostic factor for overall survival in multivariate analysis (HR 1.013 [1.000-1.026], P = 0.042) including other prognostic factors (age, extent of resection, postoperative KPS).Postoperative infarct volume significantly correlates as an independent factor with overall survival after glioblastoma surgery. Besides the influence of perioperative infarction on postoperative KPS, postoperative hypoxia might also have an effect on tumor biology initiating infiltrative growth and therefore impaired survival.
    Keywords: Glioblastoma ; Infarct Volume ; Karnofsky Performance Score ; Overall Survival ; Brain Neoplasms -- Diagnostic Imaging ; Glioblastoma -- Diagnostic Imaging
    E-ISSN: 1949-2553
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Cancers, 01 November 2018, Vol.10(11), p.456
    Description: Gliomas are primary brain tumors that present the majority of malignant adult brain tumors. Gliomas are subdivided into low- and high-grade tumors. Despite extensive research in recent years, the prognosis of malignant glioma patients remains poor. This is caused by naturally highly infiltrative...
    Keywords: Primary Brain Tumor ; Migration and Invasion ; Irradiation ; Survival ; Tumor Heterogeneity ; Personalized Medicine ; Brain Metastases ; Radiotherapy ; Treatment Resistance ; Medicine
    E-ISSN: 2072-6694
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Sci Rep, 2018, Vol.8(1), pp.4561-4561
    Description: Recent studies suggested that postoperative hypoxia might trigger invasive tumor growth, resulting in diffuse/multifocal recurrence patterns. Aim of this study was to analyze distinct recurrence patterns and their association to postoperative infarct volume and outcome. 526 consecutive glioblastoma patients were analyzed, of which 129 met our inclusion criteria: initial tumor diagnosis, surgery, postoperative diffusion-weighted imaging and tumor recurrence during follow-up. Distinct patterns of contrast-enhancement at initial diagnosis and at first tumor recurrence (multifocal growth/progression, contact to dura/ventricle, ependymal spread, local/distant recurrence) were recorded by two blinded neuroradiologists. The association of radiological patterns to survival and postoperative infarct volume was analyzed by uni-/multivariate survival analyses and binary logistic regression analysis. With increasing postoperative infarct volume, patients were significantly more likely to develop multifocal recurrence, recurrence with contact to ventricle and contact to dura. Patients with multifocal recurrence (Hazard Ratio (HR) 1.99, P = 0.010) had significantly shorter OS, patients with recurrent tumor with contact to ventricle (HR 1.85, P = 0.036), ependymal spread (HR 2.97, P = 0.004) and distant recurrence (HR 1.75, P = 0.019) significantly shorter post-progression survival in multivariate analyses including well-established prognostic factors like age, Karnofsky Performance Score (KPS), therapy, extent of resection and patterns of primary tumors. Postoperative infarct volume might initiate hypoxia-mediated aggressive tumor growth resulting in multifocal and diffuse recurrence patterns and impaired survival.
    Keywords: Article;
    ISSN: 2045-2322
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Annals of Surgical Oncology, 2018, Vol.25(Supplement 3), pp.989-989
    Description: Due to a metadata tagging error the names of Stephanie E. Combs and Jan S. Kirschke were indexed incorrectly. Stephanie E. is the author’s given name, and Jan S. is the author’s given name.
    Keywords: Glioblastoma;
    ISSN: 1068-9265
    E-ISSN: 1534-4681
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Annals of Surgical Oncology, 2018, Vol.25(2), pp.558-564
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1245/s10434-017-6253-0 Byline: Stefanie Bette (1), Melanie Barz (2), Benedikt Wiestler (1), Thomas Huber (3), Julia Gerhardt (2), Niels Buchmann (2), Stephanie Combs (4,7,8), Friederike Schmidt-Graf (5), Claire Delbridge (6), Claus Zimmer (1), Jan Kirschke (1), Bernhard Meyer (2), Yu-Mi Ryang (2), Florian Ringel (2), Jens Gempt (2) Abstract: Background Incomplete resection of glioblastoma is discussed controversially in the era of combined radiochemotherapy. Objective The aim of this study was to analyze the benefit of subtotal tumor resection for glioblastoma patients as this was recently questioned in the era of radiochemotherapy. Methods Overall, 209 patients undergoing surgery for newly diagnosed WHO grade IV gliomas were retrospectively analyzed, and pre- and postoperative tumor volumes were manually segmented (cm.sup.3). Survival analyses were performed, including prognostic factors such as age, Karnofsky performance score (KPS), O.sup.6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status, and adjuvant treatment regimen. Results Pre- and postoperative tumor volume is significantly associated with pre- and postoperative KPS, as well as age (p 〈 0.001). Postoperative tumor volume remained a significant prognostic factor in a multivariate analysis, independent of other prognostic factors (hazard ratio 1.0365, 95% confidence interval 1.0235--1.0497, p 〈 0.001). Conclusions In the era of molecularly-driven radiochemotherapy, glioblastoma surgery remains a major prognostic factor. Even in situations in which a gross total resection cannot be achieved, maximum safe reduction of tumor burden should be attempted. Author Affiliation: (1) 0000 0004 0477 2438, grid.15474.33, Department of Neuroradiology, Klinikum rechts der Isar der Technischen Universitat, Munich, Germany (2) 0000 0004 0477 2438, grid.15474.33, Department of Neurosurgery, Klinikum rechts der Isar der Technischen Universitat, Munich, Germany (3) 0000 0004 1936 973X, grid.5252.0, Department of Radiology, Ludwig-Maximilians-University, Munich, Germany (4) 0000 0004 0477 2438, grid.15474.33, Department of Radiation Oncology, Klinikum rechts der Isar der Technischen Universitat, Munich, Germany (5) 0000 0004 0477 2438, grid.15474.33, Department of Neurology, Klinikum rechts der Isar der Technischen Universitat, Munich, Germany (6) 0000 0004 0477 2438, grid.15474.33, Department of Neuropathology, Klinikum rechts der Isar der Technischen Universitat, Munich, Germany (7) 0000 0004 0483 2525, grid.4567.0, Institute for Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum Munchen, 85764, Oberschlei[sz]heim, Germany (8) Deutsches Konsortium fur Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany Article History: Registration Date: 07/11/2017 Received Date: 10/09/2017 Online Date: 20/11/2017 Article note: Stefanie Bette and Melanie Barz are contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1245/s10434-017-6253-0) contains supplementary material, which is available to authorized users. A correction to this article is available online at https://doi.org/10.1245/s10434-018-6443-4.
    Keywords: Methylation – Analysis ; Adjuvant Chemotherapy – Analysis ; Tumor Removal – Analysis ; Transferases – Analysis ; Glioblastomas – Prognosis ; Glioblastomas – Care and Treatment ; Glioblastomas – Analysis;
    ISSN: 1068-9265
    E-ISSN: 1534-4681
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages