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  • Erbersdobler, Andreas  (8)
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  • 1
    Language: English
    In: The Journal of Urology, April 2013, Vol.189(4), pp.e390-e391
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 2
    Language: English
    In: The Journal of Urology, April 2013, Vol.189(4), pp.e389-e389
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: The Journal of Urology, April 2013, Vol.189(4), pp.e310-e310
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: Therapeutic Advances in Urology, May 2017, Vol.9(5), pp.121-122
    Keywords: Medicine
    ISSN: 1756-2872
    E-ISSN: 1756-2880
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  • 5
    In: Aktuelle Urologie, 2018, Vol.49(03)
    In: Aktuelle Urologie, 2017, Vol.49(03), pp.262-265
    Description: Das (para-)testikuläre Zystadenom entsteht aus einer oviduktähnlichen Struktur, die morphologisch nahezu identisch mit dem Oberflächenepithel des Ovars ist (Müllerʼsches Epithel). Es ist ein seltener benigner Tumor des Erwachsenenalters mit geringem malignen Potential. Das Durchschnittsalter liegt bei Erstdiagnose in den bisher beschriebenen Fällen bei 30 Jahren (11 – 75 Jahre). In Regel sind es asymptomatische zystische Raumforderungen, die häufig als Rete testis- oder Nebenhodentumoren fehlinterpretiert werden, da makroskopisch nicht sicher identifiziert werden kann, ob sie intra- oder paratestikulär entstanden sind . Bilaterale paratestikuläre Zystadenome sind mit dem Von-Hippel-Lindau-Syndrom assoziiert (18 % der von Hippel-Lindau-Patienten) und können aufgrund einer Obstruktion der samenleitenden Gänge mit Infertilität einhergehen . In der Literatur finden sich nur 12 Publikationen mit 35 berichteten Fällen paratestikulärer Zystadenome aus den Jahren 1986 – 2016, was die Seltenheit dieser Tumorentität verdeutlicht. Obwohl die Mehrheit gutartige Verläufe zeigt, werden aber auch wenige Fälle mit Rezidivbildung und/oder Metastasierung beschrieben, so dass eine Langzeitnachsorge ratsam erscheint . Aufgrund der Seltenheit gibt es jedoch keine allgemeinen Empfehlungen zur Therapie. Wir berichten von einem 74-jährigen Patienten mit einem seltenen paratestikulären papillären Zystadenom.
    Keywords: Paratestikuläre raumforderung ; Zystische läsion ; Zystadenom ; Gutartige neoplasie mit geringem malignen potential ; Paratesticular tumour ; Cystic lesion ; Cystadenoma ; Benign neoplasm with a low malignant potential
    ISSN: 0001-7868
    E-ISSN: 1438-8820
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  • 6
    Language: English
    In: Deutsches Arzteblatt international, 28 September 2018, Vol.115(39), pp.646-652
    Description: The incidence of penile cancer in Europe lies in the range of 0.9 to 2.1 cases per 100 000 persons per year. Carcinogenesis is associated with human papilloma virus (HPV) infection and with chronic inflammation. This review is based on publications (2010-2017) retrieved by a selective search in PubMed and EMBASE and on the guidelines of the European Association of Urology, the European Society of Medical Oncology, the National Comprehensive Cancer Network, and the National Institute for Health and Care Excellence (NICE). 95% of cases of penile cancer are accounted for by squamous cell carcinoma, whose numerous subtypes have different clinical courses. Chronic preputial inflammation due to phimosis or lichen sclerosus is often associated with penile cancer. Circumcision lowers the risk of penile cancer (hazard ratio: 0.33). Maximally organ-preserving surgery with safety margins of no more than a few millimeters is the current therapeutic standard, because a local recurrence, if it arises, can still be treated locally with curative intent. Local radiotherapy can be performed in early stages. Lymphogenic metastasis must be treated with radical lymphadenectomy and adjuvant chemotherapy. Patients with clinically unremarkable inguinal lymph nodes nonetheless need invasive lymph node staging because of the high rate of lymphogenic micrometastasis. Penile cancer is curable in all early stages with the appropriate treatment, but its prognosis depends crucially on the proper management of the regional (i.e., inguinal) lymph nodes. In many countries, the treatment of this rare disease entity has been centralized.
    Keywords: Penile Neoplasms -- Diagnosis
    E-ISSN: 1866-0452
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  • 7
    In: Nuklearmedizin, 2018, Vol.57(01)
    In: Nuklearmedizin, 2018, Vol.57(01), pp.26-30
    Description: Aim: Accurate staging of penile cancer requires invasive methods such as sentinel node biopsy or lymphadenectomy (LAD). We assessed the value of [ F]FDG PET/CT for non-invasive nodal staging in penile cancer (PC) patients before inguinal LAD. Patients and methods: 41 consecutive patients with PC (stage pT1 or higher, cN0) received [ F]FDG PET/CT before undergoing bilateral modified or radical inguinal staging LAD. Lymph nodes with a visually increased [ F]FDG uptake were classified as suspicious of lymph node metastases (LNM). Standardized uptake value (SUV) of suspicious inguinal lymph nodes was determined. Results of [ F]FDG PET/CT were correlated with histopathology. Results: In total 623 lymph nodes were resected, in 10 patients LNM were histologically confirmed (14/623 lymph nodes). In patient-based analysis [ F]FDG PET/CT showed a sensitivity and specificity of 80% and 68 %, respectively, a positive predictive value (PPV) of 44 % and a negative predictive value (NPV) of 91 %. In the groin-based analysis, [ F]FDG PET/CT had a sensitivity of 69 %, a specificity of 77 %, a PPV of 36 % and a NPV of 93 %. There was no significant difference in SUV and SUV between true positive and false positive lymph nodes (p = 0.093 and 0.069, respectively). Conclusion: [ F]FDG PET/ CT shows a high NPV in penile cancer patients without clinically evident LNM. However, due to its limited sensitivity (especially with respect to LNM of small size) and specificity (i. e. in the differentiation between (post)inflammatory and metastatic lymph nodes) [ F]FDG PET/CT cannot replace invasive nodal staging.
    Keywords: Penile cancer[ f]fdg pet/ct ; Nodal staging ; Inguinal lymphadenectomy ; Histopathology ; Peniskarzinom[ f]fdg pet/ct ; Lymphknotenstaging ; Inguinale lymphadenektomie ; Histopathologie
    ISSN: 0029-5566
    E-ISSN: 2567-6407
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  • 8
    Language: English
    In: European Urology Focus, July 2018, Vol.4(4), pp.599-607
    Description: For penile cancer (PC) there are no known molecular predictors of lymphatic spread and/or chemoresistance. To identify functional biomarkers that can predict malignant progression and treatment responsiveness. We used four patient-derived PC cell lines and measured invasion and capillary tube formation, chemoresponsiveness, and mRNA and protein expression. Data were further validated in E2F1 transcription factor knockdown and overexpression experiments. We quantified E2F1 transcript levels in a set of nonmetastatic tumours (NM), metastasised primary tumours (PT), and lymph node metastases (M) from 24 patients. E2F1 immunohistochemistry was performed in another set of 13 PC biopsies. Relationships between different parameters were analysed using Student tests. Transcript levels in patient samples were compared using Mann-Whitney tests. Significance was set at 〈 0.05. In cell lines established from lymph node metastases, E2F1 was more abundantly expressed, pRB was inactivated, and CDK2, CDK4, and cyclins D and E were elevated in comparison to cells from primary PC. Overexpression of E2F1 enhanced migratory capacity and lymphatic endothelial tubule formation, while depletion reduced invasiveness and increased chemosensitivity. VEGFR-3 and VEGF-C and mesenchymal markers were upregulated by high E2F1. E2F1 was clearly upregulated in infiltrative and metastatic primary tumours and metastases (NM vs PT, 〈 0.05; NM vs M, 〈 0.0005). E2F1 Quick scores increased from grade I to grade III tumours. A limitation of the study is the small number of patients. E2F1 is a driver of invasion and lymphatic dissemination and promotes chemoresistance. E2F1-related biomarkers might assist in stratifying PC patients for different treatment regimens. The availability of penile cancer cell lines allows molecular research on the mechanisms underlying metastasis and chemotherapy. A critical pathway involved in both features has been identified and may lead to better patient stratification for treatment selection. Functional analyses in cell lines from patients with primary and metastatic penile cancer revealed that E2F1 drives invasiveness, lymphogenic metastasis, and chemoresistance. This allowed identification of prognostic biomarkers that could open up entirely new possibilities in cancer diagnosis and therapy.
    Keywords: Penile Squamous Cell Carcinoma ; E2f1 ; Cancer Invasion ; Chemotherapy ; Lymphangiogenesis ; Experimental Therapeutics ; Medicine
    ISSN: 2405-4569
    E-ISSN: 2405-4569
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