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  • Fröhlich, Holger  (2)
  • Kent Academic Repository (University of Kent)  (2)
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  • Kent Academic Repository (University of Kent)  (2)
  • 1
    In: Sarin, Navin and Engel, Florian and Kalayda, Ganna V and Frötschl, Roland and Cinatl, Jindrich and Rothweiler, Florian and Michaelis, Martin and Fröhlich, Holger and Jaehde, Ulrich (2016) Knowledge-based approach to identify key determinants of cisplatin sensitivity . International journal of clinical pharmacology and therapeutics, .
    Keywords: RM Therapeutics. Pharmacology
    ISSN: 0946-1965
    Source: University of Kent
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  • 2
    In: Sarin, Navin and Engel, Florian and Rothweiler, Florian and Cinatl, Jindrich and Michaelis, Martin and Frötschl, Roland and Fröhlich, Holger and Kalayda, Ganna V (2018) Key Players of Cisplatin Resistance: Towards a Systems Pharmacology Approach. International Journal of Molecular Sciences, 19 (3). pp. 767-785.
    Description: The major obstacle in the clinical use of the antitumor drug cisplatin is inherent and acquired resistance. Typically, cisplatin resistance is not restricted to a single mechanism demanding for a systems pharmacology approach to understand a whole cell’s reaction to the drug. In this study, the cellular transcriptome of untreated and cisplatin-treated A549 non-small cell lung cancer cells and their cisplatin-resistant sub-line A549rCDDP2000 was screened with a whole genome array for relevant gene candidates. By combining statistical methods with available gene annotations and without a previously defined hypothesis HRas, MAPK14 (p38), CCL2, DOK1 and PTK2B were identified as genes possibly relevant for cisplatin resistance. These and related genes were further validated on transcriptome (qRT-PCR) and proteome (Western blot) level to select candidates contributing to resistance. HRas, p38, CCL2, DOK1, PTK2B and JNK3 were integrated into a model of resistance-associated signalling alterations describing differential gene and protein expression between cisplatin-sensitive and -resistant cells in reaction to cisplatin exposure.
    ISSN: 1422-0067
    Source: University of Kent
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