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  • Hennenlotter, Jörg  (13)
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  • 1
    Language: English
    In: The Journal of Urology, April 2012, Vol.187(4), pp.e535-e535
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 2
    Language: English
    In: The Journal of Urology, April 2018, Vol.199(4), pp.e366-e366
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: European Journal of Radiology, 2011, Vol.79(2), pp.189-195
    Description: To evaluate the value of T2w endorectal MRI (eMRI) for correct detection of tumor foci within the prostate regarding tumor size. 70 patients with histologically proven prostate cancer were examined with T2w eMRI before radical prostatectomy at a 1.5 T scanner. For evaluation of eMRI, two radiologists evaluated each tumor focus within the gland. After radical prostatectomy, the prostates were prepared as whole-mount sections, according to transversal T2w eMRI. For each slice, tumor surroundings were marked and compared with eMRI. Based on whole-mount section, 315 slices were evaluated and 533 tumor lesions were documented. Based on the T2w eMRI, 213 tumor lesions were described. In 137/213, histology could prove these lesions. EMRI was able to visualize 0/56 lesions with a maximum size of 〈0.3 cm (detection rate 0%), between 0.3 and 0.5 cm 4/116 (3%), between 1 and 0.5 cm 22/169 (13%), between 2 and 1 cm 61/136 (45%) and for 〉2 cm 50/56 (89%). False positive eMRI findings were: 〈0.3 cm = 0, 0.5–0.3 cm = 12, 0.5–1 cm = 34, 1–2 cm = 28 and 〉2 cm = 2. T2w eMRI cannot exclude prostate cancer with lesions smaller 10 mm and 0.4 cm respectively. The detection rate for lesions more than 20 mm (1.6 cm ) is to be considered as high.
    Keywords: Endorectal Mri ; Detection Rate ; Prostate Cancer ; T2w Mri ; Tumor Size ; Whole-Mount Specimens ; Medicine
    ISSN: 0720-048X
    E-ISSN: 1872-7727
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  • 4
    Language: English
    In: World Journal of Urology, 2013, Vol.31(2), pp.351-358
    Description: BACKGROUNDGalactin-3 is a cell adhesion molecule involved in tumor progression. Our aim was to examine Gal-3 expression in tumor, benign tissue adjacent to the tumor (adjacent-benign) and benign prostate specimens and correlated it with biochemical recurrence. MATERIALS AND METHODSTissue microarrays were prepared from 83 tumor, 78 adjacent-benign and 75 benign tissues obtained from 83 patients undergoing prostatectomy for clinically localized prostate cancer. Tissues were stained using a Gal-3 antibody and immunohistochemistry. The staining was graded between 0 and 300 depending upon staining intensity and the area of staining. In 37 patients on whom there was follow-up (Mean: 57.8 months; Median: 68 months), staining intensity was correlated with biochemical recurrence. RESULTSGal-3 showed both nuclear and cytoplasmic localization in benign, adjacent-benign and tumor tissues. Median Gal-3 staining scores significantly decreased from benign (192.5) to adjacent-benign (148.8 p = 0.007) and to tumor (108.8; p 〈 0.0001) tissues. In univariate analysis, age (p = 0.028), Gleason sum (p = 0.007), T stage (p = 0.011), seminal vesicle invasion (p = 0.009), pre-operative prostate-specific antigen (p = 0.045) and Gal-3 staining in tumor tissues (0.018) significantly correlated with biochemical recurrence. In multivariate analysis, Gal-3 expression in tumor (p = 0.04), adjacent-benign (p = 0.037) and benign (p = 0.005) tissues significantly correlated with biochemical recurrence. Gal-3 staining in tumor tissues had 91.7 % sensitivity, 64 % specificity and 73 % accuracy in predicting biochemical recurrence. CONCLUSIONSThis is the first study that showed a decreasing gradient of Gal-3 expression in benign, adjacent-benign and tumor tissues. Gal-3 expression may be useful in predicting biochemical recurrence.
    Keywords: Galectin-3 ; Biochemical recurrence ; Prostate cancer ; Tissue microarray
    ISSN: 0724-4983
    E-ISSN: 1433-8726
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  • 5
    Language: English
    In: European Urology Supplements, 2010, Vol.9(2), pp.232-232
    Keywords: Medicine
    ISSN: 1569-9056
    E-ISSN: 1878-1500
    Source: ScienceDirect Journals (Elsevier)
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  • 6
    Language: English
    In: Urologia Internationalis, May 2010, Vol.84(4), pp.388-394
    Description: Objectives: Endorectal coil magnetic resonance imaging (EC-MRI) is useful to evaluate prostate cancer localization. Herein, we evaluate sensitivity and specificity of EC-MRI in different regions of the prostate by comparing the acquired images to whole-mount sections of the prostate after radical prostatectomy. Methods: 69 patients with localized prostate cancer were included. After virtually dividing the prostate into 12 sectors, results of EC-MRI were compared to corresponding whole-mount sections by contingency analysis. Sensitivity and specificity were calculated for each of the 12 areas as well as for the dorsal and ventral region. Results: Sensitivity right/left was dorsal apex/mid/base 41/41, 60/67 and 73/79%; ventral 33/52, 43/42 and 47/52%. Specificity right/left was dorsal apex/mid/base 92/89, 82/75 and 88/69%; ventral 100/100, 100/92 and 88/83%. Local sensitivity and specificity regarding dorsal versus ventral was 88/100 and 65/87%. Conclusions: Local sensitivity decreased from basodorsal to apicoventral direction, whereas local specificity increased in the same direction. Therefore, prostate cancers demonstrated by MRI are more prone to be detected in the basodorsal region, whereas less false-positive results are found in the apicoventral region. These variations in topographical specificity and sensitivity need to be considered before radical prostatectomy or MRI-guided biopsy.
    Keywords: Original Paper ; Endorectal Coil ; Local Staging ; Magnetic Resonance Imaging ; Radical Prostatectomy ; Endorectal Coil Magnetic Resonance Imaging, Sensitivity and Specificity ; Medicine
    ISSN: 0042-1138
    E-ISSN: 1423-0399
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  • 7
    Language: English
    In: World Journal of Urology, 2012, Vol.30(4), pp.547-552
    Description: XPA-210 is a proliferation marker derived from Thymidine kinase-1. It is of clinical significance in kidney, breast, and bladder cancer. There are no data available for XPA-210 in prostate cancer (PC). Herein, we aim to determine the clinical usefulness of XPA-210 in PC.In a retrospective study, cancer and benign tissue samples of 103 patients (median age 65 years, median PSA 9.04 ng/ml, median Gleason score 6) who underwent prostatectomy were constructed to a tissue micro array and stained for XPA-210. Semi-quantitative results were correlated with pathological and clinical data by Wilcoxon–Kruskall–Wallis and linear regression analysis. Expression levels in PC were correlated between the time of biochemical recurrence and the time to development of metastasis by the Kaplan–Meier method. Multivariate analysis was done to correlate those with the resection status.Mean staining score was 0.51–0.14 for tumor and benign tissue (P 〈 0.0001). Tumor staining score was significantly associated with Gleason score 〈6/≥6 (P 〈 0.0001) and T2/T 〉2 (P = 0.0007). When dividing the tumor score by the mean value, higher expression of XPA-210 was associated with a shorter time to biochemical recurrence (P = 0.003) and time to development of metastasis (P = 0.0061). Tumor staining (P = 0.0371) was an independent prognostic factor for biochemical relapse regardless of resection status.XPA-210 is a new tissue-based prognostic marker for prostate cancer histopathology. It reliably differentiates tumor and normal prostatic tissue predicting biochemical relapse and onset of metastatic disease. XPA-210 might be clinically useful for individual decision-making in PC-treatment.
    Keywords: Prostate cancer ; XPA-210 ; Biochemical recurrence ; Metastatic disease ; Proliferation
    ISSN: 0724-4983
    E-ISSN: 1433-8726
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  • 8
    Language: English
    In: World Journal of Urology, 2013, Vol.31(2), pp.345-350
    Description: BACKGROUND: Preclinical studies demonstrated effects of drugs inhibiting the mevalonate pathway including nitrogen-containing bisphosphonates (N-BPs) and statins on tumor growth and progression. The exact role of this pathway in prostate cancer (PC) has not been identified yet. Herein, we evaluate the expression of farnesyl pyrophosphate synthase (FPPS), the key enzyme of the mevalonate pathway, in PC.PATIENTS AND METHODS: Prostate cancer (PC) and benign prostate tissue of 114 men who underwent radical prostatectomy were constructed to a tissue microarray. Immunohistochemical staining of FPPS was quantified by the Remmele/Stegner immunoreactivity-score. Patients' clinical follow-up was assessed. IRS was correlated to pathological and clinical data. The impact of FPPS expression on clinical course was assessed univariate and multivariate.RESULTS: Mean IRS in PC and benign tissue was 5.7 (95% CI 5.0-6.5) and 2.6 (2.1-3.0, p〈0.0001). Mean IRS in PC tissue of patients with organ-confined and locally advanced disease (pT≥3) was 5.09 (4.22-5.96) and 6.87 (5.57-8.17, p=0.035). IRS of PC tissue significantly correlated with Gleason score (p=0.03). Patients with PC tissue IRS 〉3 showed shorter recurrence-free survival compared to the remaining (p=0.01). Increased FPPS expression is an independent risk factor for early biochemical recurrence (p=0.032).CONCLUSIONS: This is the first study on FPPS in PC specimens. The association of FPPS with established histopathological risk parameters and biochemical recurrence implicates a contribution of the mevalonate pathway to PC progression. Further functional analysis is required to explore the role of this pathway in PC and to investigate whether FPPS expression affects the response of PC cells to N-BPs.
    Keywords: Prostate cancer ; Bisphosphonates ; Farnesyl pyrophosphate synthase ; Zoledronic acid ; Mevalonate pathway
    ISSN: 0724-4983
    E-ISSN: 1433-8726
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  • 9
    Language: English
    In: Urologia Internationalis, June 2011, Vol.86(4), pp.393-398
    Description: Objectives: Endorectal coil MRI (endoMRI) of the prostate is useful to evaluate tumor localization. There is little evidence on patient characteristics affecting its diagnostic performance. We evaluate the influence of clinical and histological parameters on the accuracy of endoMRI. Methods: Sixty-nine patients with prostate cancer were included. After virtually dividing the prostate into pixels of 1 cm2, results of endoMRI were compared with those from prostatectomy specimens’ whole-mount sections. Univariate and multivariate analyses were performed to calculate the impact of clinical and histological parameters on the number of appropriately described pixels. Results: In 9, no tumor could be demonstrated by endoMRI. 48.3% of patients were staged correctly, 23.3% were over- and 28.3% understaged. Mean rates of correctly labeled pixels were 0.44 (± 0.04 SEM) for tumor and 0.90 (± 0.01) for benign segments. In univariate analysis, the rate of correctly labeled tumor segments showed significant positive correlations with Gleason score ≧7 and negative correlations with prostate weight and multifocality. The rate of correctly labeled benign segments showed significant negative correlation with tumor weight. All factors were independent variables in multivariate analysis. Conclusions: The reliability of endoMRI depends on clinical parameters. Higher Gleason scores, unifocal tumors and smaller prostate volumes ameliorate endoMRI performance.
    Keywords: Original Paper ; Endorectal Coil ; Local Staging ; Radical Prostatectomy ; Prostate Cancer ; Magnetic Resonance Imaging ; Medicine
    ISSN: 0042-1138
    E-ISSN: 1423-0399
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  • 10
    In: BJU International, August 2008, Vol.102(3), pp.371-382
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1464-410X.2008.07703.x Keywords: prostate cancer; PKB/Akt; mTOR; FKHRL1; 4E-BP1 Abstract: OBJECTIVE To provide a rational basis for targeted treatment approaches in prostate cancer deregulation of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (PKB/Akt) system was analysed. PATIENTS AND METHODS In all, 45 patients with primary localized prostate cancer that underwent radical prostatectomy were included in the present study. Upon scoring of the pathological grade, expression and phosphorylation levels of PKB/Akt and relevant downstream targets were determined in tissue specimens by immunohistochemistry using specific antibodies against PTEN, PKB/Akt, its downstream targets, and the respective phosphorylated proteins. RESULTS Most patients (〉90%) had up-regulated expression and/or phosphorylation of PKB/Akt in the malignant tissue compared with the surrounding benign tissue, with a higher prevalence of increased phosphorylated PKB/Akt in patients with Gleason scores of [greater than or equal to]6 (100%) compared with those with Gleason scores of 4-5 (five of 13 patients), and in particular in patients with clinical progression. Up-regulated phosphorylation of PKB/Akt occurred either in association with loss or inactivation of PTEN or in a PTEN-independent manner. Enhanced phosphorylation levels of the PKB/Akt substrates glycogen synthase kinase 3, the mammalian target of rapamycin or the forkhead transcription factor like 1 (FKHRL1) were found in 29%, 42% and 40% of the tumours, respectively. Of these, only increased phosphorylated-FKHRL1 levels correlated with clinical progression. Interestingly, 80% of patients had a notable overexpression but not phosphorylation of the eucaryotic initiation factor 4E binding protein. CONCLUSION Deregulation of p-PKB/Akt is common in localized prostate cancer and has a putative value as predictive marker for disease progression and as therapeutic target. However, as a consequence of the substantial heterogeneity in the expression and phosphorylation levels of relevant PKB/Akt effector pathways, for a rational use of specified inhibitors of the PI3K/PKB system a complex pattern testing of expression and activity of the respective target proteins for prediction of efficacy and prognosis seems mandatory. Author Affiliation: CCC Tubingen, Center of Urogenital Oncology, Departments of(*)Radiation Oncology, ([double dagger])Urology, and (s.)Pathology, Tubingen, and ([dagger])University of Duisburg-Essen, Department of Molecular Cell Biology, Essen, Germany Article History: Accepted for publication 7 January 2008 Article note: Prof Dr Claus Belka, CCC Tubingen, Department of Radiation Oncology, Hoppe-Seyler-Str. 3, 72076 Tubingen, Germany., e-mail: claus.belka@uni-tuebingen.de
    Keywords: Prostate Cancer ; Pkb/Akt ; Mtor ; Fkhrl1 ; 4e‐Bp1
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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