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  • Hsieh, Pei-Wen  (47)
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  • 1
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(10), p.e111365
    Description: Neutrophil activation is associated with the development of organ injury after trauma-hemorrhagic shock. In the present study, ursolic acid inhibited the superoxide anion generation and elastase release in human neutrophils. Administration of ursolic acid attenuated trauma-hemorrhagic shock-induced...
    Keywords: Sciences (General)
    ISSN: 09680896
    E-ISSN: 1932-6203
    E-ISSN: 14643391
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  • 2
    Language: English
    In: BioMedicine, September 2013, Vol.3(3), pp.106-113
    Description: (PL) is a medicinal mushroom used to prevent or treat gastroenteric dysfunction, diarrhea, hemorrhage, allergy, diabetes, and cancer in East Asia, especially in China, Japan, and Korea. To demonstrate its pharmacological value and mechanism, and translate PL into western-accepted therapy, many researchers have investigated the effects of extracts from fruit-bodies (or mycelium) of PL by means of various and models. Subsequently, many small molecular weight pure components were isolated from extracts of PL to identify their pharmacological properties and mechanisms. These studies suggest PL and its bioactive compounds as promising candidates as anticancer, anti-inflammatory, and immunomodulating agents. This review comprehensively covers literature on these extracts, pure components, and potential therapeutic applications of PL from 1999 to June 2011. In particular, small molecular weight compounds that exhibit biological activity as well as pharmacological effects on PL's anticancer, anti-inflammatory, antidiabetic, neuro- and/or hepatic-protective, and immunomodulating activities are reviewed.
    Keywords: Anticancer ; Anti-Inflammatory ; Bioactive Compounds ; Fruiting Body ; Phellinus Linteus ; Medicine
    ISSN: 2211-8020
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: Toxicology and Applied Pharmacology, 01 December 2015, Vol.289(2), pp.330-340
    Description: Anoikis is defined as apoptosis, which is induced by inappropriate cell–matrix interactions. Cancer cells with anoikis resistance tend to undergo metastasis, and this phenomenon has been reported to be associated with integrin and FAK activity. HPW-RX40 is a derivative of 3,4-methylenedioxy-β-nitrostyrene, which is known to prevent platelet aggregation by inhibition of integrin. In the present study, we investigated the effect of HPW-RX40 on an anoikis-resistant human breast cancer cell line MDA-MB-231. HPW-RX40 inhibited cell aggregation and induced cell death in suspending MDA-MB-231 cells, but had only little effect on the monolayer growth of adherent cells. Analysis of caspase activation and poly (ADP-ribose) polymerase (PARP) cleavage confirmed anoikis in HPW-RX40-treated suspending cancer cells. HPW-RX40 also affected the Bcl-2 family proteins in detached cancer cells. Furthermore, HPW-RX40 inhibited detachment-induced activation of FAK and the downstream phosphorylation of Src and paxillin, but did not affect this pathway in adherent cancer cells. We also found that the expression and activation of β1 integrin in MDA-MB-231 cells were reduced by HPW-RX40. The combination of HPW-RX40 with an EGFR inhibitor led to enhanced anoikis and inhibition of the FAK pathway in breast cancer cells. Taken together, our results suggest that HPW-RX40 restores the anoikis sensitivity in the metastatic breast cancer cells by inhibiting integrin and subsequent FAK activation, and reveal a potential strategy for prevention of tumor metastasis.
    Keywords: Anoikis ; Β-Nitrostyrene ; Integrin ; Fak ; Metastasis ; Breast Cancer ; Pharmacy, Therapeutics, & Pharmacology ; Public Health
    ISSN: 0041-008X
    E-ISSN: 1096-0333
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  • 4
    Language: English
    In: Phytochemistry, April 2013, Vol.88, pp.67-73
    Description: Three 1,5-diphenylpent-3-en-1-ynes and three methyl naphthalene carboxylates, along with 25 known compounds, were isolated from the stems and leaves of . ► Henna is a well-known herb used for centuries for hair care and healing. ► Henna is prescribed for skin diseases due to its anti-inflammatory activity. ► Three 1,5-diphenylpent-3-en-1-ynes and three methyl naphthalene carboxylates were isolated from henna. ► Two of the isolated compounds exhibited potent anti-inflammatory activity. (Lythraceae) known as henna is one of the most popular and ancient plants used in cosmetics and hair dying. It is cultivated for its leaves but other parts such as seeds, flowers, stem bark and roots are also used in traditional medicine for millennia. Henna tattoo paste also proved to be beneficial for wound healing and in several skin diseases suggesting potent anti-inflammatory activity. To evaluate henna anti-inflammatory activity, 31 compounds, including three 1,5-diphenylpent-3-en-1-yne derivatives, lawsochylin A-C and three methyl naphthalene carboxylates, lawsonaphthoate A-C, were isolated from the stems and leaves of henna utilizing a bioassay-guided fractionation. The structures of the compounds were elucidated by spectroscopic data. Two compounds, lawsochylin A and lawsonaphthoate A showed potent anti-inflammatory activity by inhibition of superoxide anion generation (IC = 1.80 and 1.90 μg/ml) and elastase release (IC = 1.58 and 3.17 μg/ml) of human neutrophils in response to fMLP or cytochalasin B. Moreover, the known compounds, luteolin, apigenin, 4 -4-hydroxy-α-tetralone, and 2-butoxysuccinic acid, also showed potent inhibition of superoxide anion generation (IC = 0.75–1.78 μg/ml) and elastase release (IC = 1.62–3.61 μg/ml).
    Keywords: Henna ; Lawsonia Inermis ; Lythraceae ; 1,5-Diphenylpent-3-En-1-Yne ; Methyl Naphthalene Carboxylates ; Anti-Inflammatory ; Superoxide Anion ; Elastase ; Botany
    ISSN: 0031-9422
    E-ISSN: 1873-3700
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  • 5
    Language: English
    In: Natural Product Research, 17 January 2014, Vol.28(2), pp.74-80
    Description: Three new spirostanol saponins were isolated from the EtOAc fraction of methanol extract from Tupistra chinensis rhizomes. Based on the detailed analysis of their 1D and 2D NMR spectra and chemical evidence, their structures were determined as 1β-O-acetyl-spirost-5,25(27)-dien-3α-yl-O-β-d-glucopyranoside...
    Keywords: Tupistra Chinensis ; Liliaceae ; Spirostanol Saponins ; Tupichinins B, C and D ; Chemistry
    ISSN: 1478-6419
    E-ISSN: 1478-6427
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  • 6
    Language: English
    In: European Journal of Pharmacology, 2005, Vol.527(1), pp.37-43
    Description: 2-(2-Br-phenyl)-8-methoxy-benzoxazinone (HPW-RX2), a newly synthetic benzoxazinone derivative, has previously been shown to inhibit rabbit platelet aggregation caused by thrombin and arachidonic acid. In the present study, the mechanism for the antiplatelet effect of HPW-RX2 was further investigated. In human platelets, HPW-RX2 concentration-dependently inhibited platelet aggregation, ATP release, P-selectin expression, and intracellular calcium mobilization caused by thrombin. In contrast, HPW-RX2 had no significant effect on either SFLLRN- or GYPGKF-induced platelet aggregation, indicating that HPW-RX2 did not interfere with platelet thrombin receptors. Moreover, HPW-RX2 inhibited the amidolytic activity of thrombin and prolonged the fibrinogen clotting time. These results suggest that the inhibitory effect of HPW-RX2 on thrombin-induced platelet aggregation is via direct inhibition of thrombin proteolytic activity. Besides the inhibition on thrombin, HPW-RX2 also prevented platelet aggregation, ATP release, and increase in [Ca ] caused by arachidonic acid and low concentration collagen. In a parallel manner, both arachidonic acid-induced thromboxane B and prostaglandin D formations were decreased in platelets treated with HPW-RX2. This indicates that HPW-RX2 is able to inhibit the arachidonic acid cascade at the cyclooxygenase level. This is the first report of a benzoxazinone derivative possessing both thrombin and cyclooxygenase inhibitory properties. The dual effect of HPW-RX2 might provide extra therapeutic benefits for treatment of arterial thrombosis.
    Keywords: Antiplatelet Agent ; Thrombin ; Thromboxane A 2 ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0014-2999
    E-ISSN: 1879-0712
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  • 7
    Language: English
    In: Bioorganic & Medicinal Chemistry, 2008, Vol.16(10), pp.5803-5814
    Description: Fifty-two 2-benzoylaminobenzoate analogs were synthesized and subjected to anti-platelet aggregation assay. The results revealed that most of 2-benzoylaminobenzoic acid derivatives showed selectively inhibitory effect on AA-induced platelet aggregation. Fifty-two 2-benzoylaminobenzoate analogs were synthesized and subjected to anti-platelet aggregation assay using arachidonic acid (AA), collagen (Col), thrombin (Thr), and U46619 as inducers. The results revealed that most of 2-benzoylaminobenzoic acid derivatives showed a selectively inhibitory effect on AA-induced platelet aggregation. As a result of the 2-benzoylaminobenzoic acid derivatives ( , , and ), there were no inhibitory effects on platelet aggregation induced by U46619, but these elicited an inhibitory effect on thromboxane B formation at 1.0 μM. These 2-benzoylaminobenzoate analogs were therefore proposed as cyclooxygenase inhibitors.
    Keywords: 2-Benzoylaminobenzoate Analogs ; Anti-Platelet Aggregation ; Cyclooxygenase ; Structure–Activity Relationships (SAR) ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0968-0896
    E-ISSN: 1464-3391
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  • 8
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 2007, Vol.17(6), pp.1812-1817
    Description: A series of 2-benzoylaminobenzoic esters were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Forty-seven 2-benzoylaminobenzoic esters were synthesized and evaluated in anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Most 2-benzoylamino-4-chlorobenzoic acid derivatives showed selective inhibitory effects on arachidonic acid (AA)-induced platelet aggregation. Among them, compounds and exhibited more potent inhibitory effects (ca. 200-fold) than aspirin. Additionally, compounds and showed strong inhibitory effects on neutrophil superoxide generation with IC values of 0.65 and 0.17 μM, respectively. However, compounds and exhibited dual inhibitory effects on platelet aggregation and neutrophil elastase (NE) release; therefore, these two compounds may be new leads for development as anti-inflammatory and anti-platelet aggregatory agents.
    Keywords: 2-Benzoylaminobenzoic Esters ; Anti-Inflammatory ; Anti-Platelet Aggregation Agents ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 9
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 2005, Vol.15(11), pp.2786-2789
    Description: A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. The results suggested that these compounds can provide the lead compounds for anti-inflammatory agents. A series of 2,8-disubstituted benzoxazinones were synthesized and subjected to anti-platelet aggregation, inhibition of superoxide anion generation, and inhibition of neutrophil elastase release assays. Among them, 2-(2′-substituted-phenyl)-benzoxazinones exhibited significant inhibitory effect to target assays. Additionally, all of them were more potent than aspirin on AA-induced platelet aggregation, and these suggested that 2-(2′-substituted-phenyl)-benzoxazinones also possess aspirin-like activity. On the other hand, the compounds and showed inhibitory effects on neutrophil elastase release and superoxide generation.
    Keywords: Benzoxazinones ; Anti-Platelet Aggregation ; Neutrophil Elastase ; Superoxide Generation ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 10
    Language: English
    In: Food Chemistry, 2008, Vol.107(2), pp.684-691
    Description: rhizome has long been used as an herb tonic to treat osteoporosis, arthralgia, and arthritis. The aqueous extract of . rhizome contains a high content of phenolic compounds [210.8 ± 4.6 mg catechin equivalents (CE)/g dry weight] and shows a strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity (IC = 15.93 ± 1.21 μg dry weight/ml). Further solvent partition of the aqueous extract yielded chloroform, -butanol, and water layers. Among them, -butanol layer has the highest phenol content (806.3 ± 12.3 mg CE/g dry weight) and DPPH scavenging potential (IC = 3.93 ± 0.31 μg dry weight/ml). Isolation and purification from the -butanol layer identified 12 compounds. They included four new compounds: 3′- - -hydroxybenzoylmangiferin ( ), 4′- - -hydroxybenzoylmangiferin ( ), 6′- - -hydroxybenzoylmangiferin ( ), and 3- - -hydroxybenzoylmangiferin ( ); as well as eight known compounds: mangiferin ( ), 2- -β- -xylopyranosyl-1,3,6,7-tetrahydroxyxanthone ( ), 4β-carboxymethyl-(−)-epicatechin ( ), 4β-carboxymethyl-(−)-epicatechin methyl ester ( ), eriodictyol ( ), eriodictyol-8- -β- -glucopyranoside ( ), icariside E ( ), and icariside E ( ). DPPH scavenging and Trolox equivalent antioxidant capacity (TEAC) analyses revealed that the most potent antioxidants are , , and , which exerted more than triple activity as compared with the positive controls, -tocopherol and Trolox.
    Keywords: Davallia Solida ; Dpph ; Trolox Equivalent Antioxidant Capacity (Teac) ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
    Source: ScienceDirect Journals (Elsevier)
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