Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • 1
    In: Sexually Transmitted Diseases, 1989, Vol.16(2), pp.103-106
    Description: The present study was undertaken to evaluate the utility of a gram stain of endocervical secretions in the prediction of endocervical infection with Chlamydia trachomatis. Endocervical examinations, Gram stains and chlamydial cultures were performed on 214 women who were attending a sexually transmitted diseases clinic and were at increased risk for chlamydial infection. Almost 24% of the Gram stains were judged inadequate because of the presence of ectocervical material. However, significantly higher isolation rates for C. trachomatis were found for those women with valid smears and 10 or more polymorphonuclear cells on their smear (44% vs 19%, P = .0008). This relationship was independent of the presence of gonococcal infection. Based on the results of this study, endocervical Gram stains appear to be a valuable screening tool for chlamydial infection, particularly among those without mucopurulent discharge.
    Keywords: Chlamydia Infections -- Diagnosis ; Uterine Cervicitis -- Diagnosis;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 2
    Language: English
    In: The Journal of Infectious Diseases, 1 April 1989, Vol.159(4), pp.661-669
    Description: To determine whether concurrent gonorrhea reactivates latent chlamydial infection, we studied 74 recurrent chlamydial infections and the effect of concurrent gonorrhea at the recurrent episode on the chlamydial serovar identified. Serotyping of 74 recurrent pairs of chlamydial isolates from patients attending a sexually transmitted diseases clinic indicated that 47.1% (16 of 34) with gonorrhea at the time of recurrence harbored chlamydiae of the same serovar as at the initial infection, while only 22.5% (9 of 40) without gonorrhea had the same serovar (P = .03). The proportion of recurrences by the same serovar in the group without gonorrhea did not differ from the proportion predicted by a random exposure model (22.2% vs. 18.4%, P = .46), while the proportion in the gonorrhea group did (47.1% vs. 19.8% P 〈 .0001). The possibility of reinfection did not appear more likely in the group with gonorrhea than in the group without. These observations support the hypothesis that concurrent gonorrhea can reactivate latent chlamydial infection.
    Keywords: Health sciences -- Medical conditions -- Infections ; Health sciences -- Medical conditions -- Infections ; Biological sciences -- Biology -- Microbiology ; Health sciences -- Medical sciences -- Immunology ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Medical sciences -- Immunology ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Medical conditions -- Infections ; Social sciences -- Population studies -- Human populations ; Biological sciences -- Biology -- Anatomy
    ISSN: 00221899
    E-ISSN: 15376613
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  • 3
    Language: English
    In: The Journal of Pediatrics, 1992, Vol.121(3), pp.487-493
    Description: To determine the recurrence rate of chlamydial infections, we initially screened an urban population of 1308 sexually active female adolescents for chlamydial infection at the urethral and endocervical sites; these young women were followed and had additional examinations for infection. Chlamydial infection was documented by tissue culture in 31.1% (407) of them at some time during the study. After appropriate antibiotic treatment, 68.3% (278/407) returned for test-of-cure cultures within 3 months of their initial infection; of those 278, a total of 254 had sterile cultures. These patients were followed to determine the recurrence rate of chlamydial infections. Of these 254 patients, 177 (69.7%) had one or more follow-up visits; 38.4% (68/177) had a recurrent chlamydial infection. The majority of recurrent infections were documented within 9 months of the initial infection. Recurrent infections with the same serovar were frequent, suggesting reinfection by untreated partners or possible relapse of the initial chlamydial infection. This high rate of recurrent infection suggests that female adolescents should be rescreened frequently for genitourinary chlamydial infections.
    Keywords: Medicine
    ISSN: 0022-3476
    E-ISSN: 1097-6833
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  • 4
    In: Sexually Transmitted Diseases, 1992, Vol.19(2), pp.99-104
    Description: :
    Keywords: Gonorrhea ; Care and Treatment ; Chlamydia Infections ; Clinical Epidemiology ; Evaluation ; Sexually Transmitted Diseases ; Reporting ; Medicine;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 5
    Language: English
    In: The Journal of Pediatrics, 1988, Vol.112(6), pp.1000-1004
    Description: Five hundred sixty-eight adolescent female patients receiving routine gynecologic care at urban clinics were screened by culture for infection at both the urethra and endocervix. Culture results for 562 were available from either or both sites. Positive cultures were obtained from 139 (25%). Urethral infection was not associated with either urinary tract symptoms or sterile pyuria, but urethral or endocervical infection was associated with cervical friability (P=〈0.0001), endocervical mucopus (P=0.0001), cervical erythema (P=0.0002), and cervical ectopy or erosion (P=0.01). Increased chlamydial infection rates were associated with older age (P=0.01), history of more frequent intercourse (P=0.01), and history of more than one lifetime partner (P=0.023), with a marginal association for being black (P=0.05). Method of contraception, reason for attending clinic, age at menarche, age at first intercourse, years sexually active, number of sexual partners in preceding 6 months, parity, and prior history of sexually transmitted disease were not associated with having chlamydial genitourinary infection.
    Keywords: Medicine
    ISSN: 0022-3476
    E-ISSN: 1097-6833
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  • 6
    Language: English
    In: The Journal of Infectious Diseases, 1 August 1989, Vol.160(2), pp.332-336
    Description: The relationship between acute inflammation and serovar of Chlamydia trachomatis was evaluated in patients with genital chlamydial infection who attended a sexually transmitted diseases clinic. Polymorphonuclear leukocytes (PMNLS) were enumerated on Gram's stained smears of endourethral contents in men; cervicitis was scored by visual observation of the endocervix in women. Isolates were serotyped with a monoclonal antibody-based radioimmunoassay. The distribution of serovars in 99 women did not differ in the presence or absence of cervicitis or concurrent gonorrhea. An overall difference (P = .037) was observed when serovar distributions in men with lt;3 PMNLs (n = 42), gt;10 PMNLs (n = 41), and gonococcal urethritis (n = 42) were compared. Follow-up pairwise comparisons revealed that men with lt;3 PMNLs had fewer isolates of serovars F and G than did men with gt;10 PMNLs (P 〈.05). No strong overall association was observed between inflammation and serovar.
    Keywords: Health sciences -- Medical conditions -- Diseases -- Monoclonal antibodies ; Biological sciences -- Biology -- Anatomy -- Monoclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Biological sciences -- Biology -- Microbiology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Social sciences -- Population studies -- Human populations -- Monoclonal antibodies ; Health sciences -- Medical conditions -- Infections -- Monoclonal antibodies ; Health sciences -- Medical conditions -- Diseases -- Monoclonal antibodies ; Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies
    ISSN: 00221899
    E-ISSN: 15376613
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  • 7
    In: Sexually Transmitted Diseases, 1991, Vol.18(1), pp.36-40
    Description: In developed nations, the most common sexually transmitted disease is infection with Chlamydia trachomatis. In the United States, the standard therapy for chlamydia infections involves a seven-day treatment period with tetracycline, erythromycin, or doxycycline. However, some cases require a longer treatment period, up to 21 days, to eliminate the infection. After the treatment period has ended, the patient is retested to make sure that the infection has been cured. This procedure is called a test-of-cure (TOC). But recurrent infections with the same strain of Chlamydia trachomatis, following seven days of treatment and TOC, are not uncommon, and may indicate that the standard therapy time should be increased. In an attempt to evaluate the relationship between the duration of treatment and the rate of recurrence of infection, the medical records of 2,983 patients, who were treated with the standard therapy for chlamydia infection, were reviewed. During a two-year follow-up period, the rate of recurrence of infection was 29 percent. Recurrence of infection was associated with young age, but not with gender or race. To determine if a longer treatment period could reduce the rate of recurrence of infection, 220 patients with chlamydia were treated with tetracycline for either 7 or 21 days. Among patients who returned, the recurrence rate was 14 percent for the seven-day treatment and 18 percent for the 21-day treatment. The difference in the recurrence rate between the two treatment groups was not statistically significant. It is concluded that a 21-day treatment period is no more effective than a seven-day treatment period in preventing recurrence of chlamydia infection. (Consumer Summary produced by Reliance Medical Information, Inc.)
    Keywords: Tetracyclines -- Evaluation ; Chlamydia Infections -- Drug Therapy ; Chlamydia Trachomatis;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 8
    In: Sexually Transmitted Diseases, 1992, Vol.19(6), pp.351-354
    Description: Control of bacterial sexually transmitted diseases (STD) depends on adequate antibiotic therapy. During a 4-week period, a survey concerning compliance was administered to all patients attending an STD clinic who were being treated with one of the standard antibiotic regimens for presumed gonococcal or chlamydial infections. Of the 497 eligible patients, 406 (81.7%) were surveyed between 24 hours and 72 hours after the end of treatment. Of those being treated with the standard 7-day regimen of tetracycline or erythromycin, 63.4% complied. Compliance was not associated with race, gender, symptoms, or antibiotic regimen. Those who were younger, were sexual contacts of an infected partner, or had gastrointestinal side effects were more likely not to comply with treatment.
    Keywords: Chlamydia Trachomatis ; Drug Therapy ; Neisseria Gonorrhoeae ; Patient Compliance ; Evaluation ; Medicine;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 9
    In: Sexually Transmitted Diseases, 1996, Vol.23(3), pp.226-229
    Description: BACKGROUND AND OBJECTIVES:: GOALS:: STUDY DESIGN:: The study population consisted of all 4,329 sexually active girls between the ages of 13 and 19 attending the four adolescent health clinics in Indianapolis, Indiana, during the period beginning October 1, 1985, and ending June 30, 1994. All girls were cultured for Chlamydia trachomatis, and behavioral data were collected for those attending the clinics before 1989. The trend in quarterly isolation rates was examined using linear regression analysis. RESULTS:: Results showed that there was a significant decrease (P = 0.0001), from 25.9% to 9.7%, in the first-visit chlamydial isolation rate over the study period. Behavioral data showed decreases in the frequency of sexual intercourse and in lifetime years of sexual activity, as well as an increase in condom use. CONCLUSIONS::
    Keywords: Chlamydia Infections ; Demographic Aspects ; Teenage Girls ; Health Aspects ; Medicine;
    ISSN: 0148-5717
    E-ISSN: 15374521
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  • 10
    In: Sexually Transmitted Diseases, 1987, Vol.14(3), pp.160-164
    Description: In developed nations, Chlamydia trachomatis is the most common sexually transmitted pathogen. To determine whether prior disease affects the probability of subsequent chlamydial infection, we took culture specimens from 2,546 men and 1,998 women attending a sexually transmitted diseases clinic. The men had nongonococcal urethritis and the women were contacts of men who had a positive chlamydial culture or nongonococcal urethritis. Significantly lower isolation rates for those with a history of sexually transmitted diseases were found for both men (29% vs. 38%; P less than 0.0001) and women (27% vs. 36%; P less than 0.0001). In addition, both men and women with previously documented chlamydial infections had a lower isolation rate at the index visit, if the previous infection occurred less than, as opposed to more than, six months earlier (men: 20% vs. 41%; P = 0.0006; women: 14% vs. 35%; P = 0.003). These relationships were found to be independent of age. However, the effect of partial immunity due to prior infection could not be distinguished from that of prior antibiotic therapy, and if such immunity does confer protection against reinfection, that protection appears to be both partial and of relatively short duration.
    Keywords: Chlamydia Infections -- Diagnosis ; Chlamydia Trachomatis -- Isolation & Purification ; Sexually Transmitted Diseases -- Immunology;
    ISSN: 0148-5717
    E-ISSN: 15374521
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