Phytomedicine, 2008, Vol.15(1), pp.79-83
are widely used as traditional medicine in Lebanon for treatment of different infection diseases. In the present study we reported the phytochemical composition analyzed by GC–MS of wood essential oil and cones and leaves ethanol extracts. The main components of wood essential oil were himachalol (22.50%), -himachalene (21.90%), and -himachalene (10.50%). Leaves ethanol extract was characterized by a high content of germacrene (29.40%). The same extract obtained from cones essentially contained -pinene (51.0%) and -myrcene (13.0%). Moreover, we investigated extracts, essential oil, and identified compounds for their antiviral activities against herpes simplex virus type 1 (HSV-1). Cytotoxicity was evaluated by MTT assay in Vero cells. Cones and leaves ethanol extracts exhibited an interesting activity with IC of 0.50 and 0.66 mg/ml, respectively, at non-cytotoxic concentration. A comparable activity was found when essential oil was tested (IC of 0.44 mg/ml).
Cedrus Libani A. Rich ; Antiviral Activity ; Herpes Simplex Virus (Hsv-1) ; Gc–MS Analysis ; Medicine ; Pharmacy, Therapeutics, & Pharmacology
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