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  • 1
    Language: English
    In: Phytomedicine, 2008, Vol.15(1), pp.79-83
    Description: are widely used as traditional medicine in Lebanon for treatment of different infection diseases. In the present study we reported the phytochemical composition analyzed by GC–MS of wood essential oil and cones and leaves ethanol extracts. The main components of wood essential oil were himachalol (22.50%), -himachalene (21.90%), and -himachalene (10.50%). Leaves ethanol extract was characterized by a high content of germacrene (29.40%). The same extract obtained from cones essentially contained -pinene (51.0%) and -myrcene (13.0%). Moreover, we investigated extracts, essential oil, and identified compounds for their antiviral activities against herpes simplex virus type 1 (HSV-1). Cytotoxicity was evaluated by MTT assay in Vero cells. Cones and leaves ethanol extracts exhibited an interesting activity with IC of 0.50 and 0.66 mg/ml, respectively, at non-cytotoxic concentration. A comparable activity was found when essential oil was tested (IC of 0.44 mg/ml).
    Keywords: Cedrus Libani A. Rich ; Antiviral Activity ; Herpes Simplex Virus (Hsv-1) ; Gc–MS Analysis ; Medicine ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0944-7113
    E-ISSN: 1618-095X
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  • 2
    Language: English
    In: Chemistry & Biodiversity, March 2008, Vol.5(3), pp.461-470
    Description: The chemical composition of the essential oils of ssp. ssp. , and was determined by GC/MS analysis. Essential oils have been evaluated for their inhibitory activity against SARS‐CoV and HSV‐1 replication by visually scoring of the virus‐induced cytopathogenic effect post‐infection. oil exerted an interesting activity against SARS‐CoV with an value of 120 μg/ml and a selectivity index (SI) of 4.16. This oil was characterized by the presence of ‐ocimene, 1,8‐cineole, ‐pinene, and ‐pinene as the main constituents. ssp. oil, in which ‐pinene and ‐myrcene were the major constituents, revealed antiviral activity against HSV‐1 with an value of 200 μg/ml and a SI of 5.
    Keywords: Severe Acute Respiratory Syndrome Sars ; Antiviral Activity ; Cytotoxic Activity ; Essential Oils ; Laurus Nobilis ; Ssp. ; Thuja Orientalis ; Ssp. ; Pistacia Palaestina ; Salvia Officinalis ; Satureja Thymbra
    ISSN: 1612-1872
    E-ISSN: 1612-1880
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