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  • Lanitis, Sophocles  (19)
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  • 1
    Language: English
    In: Gastroenterology, May 2010, Vol.138(5), pp.1667, 2025
    Keywords: Alphapapillomavirus -- Isolation & Purification ; Anus Diseases -- Virology ; Anus Neoplasms -- Virology ; Carcinoma, Squamous Cell -- Virology ; Condylomata Acuminata -- Virology ; Hypercalcemia -- Virology ; Papillomavirus Infections -- Virology ; Paraneoplastic Syndromes -- Virology
    E-ISSN: 1528-0012
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  • 2
    Language: English
    In: Gastroenterology, 2010, Vol.138(5), pp.1667,2025-1667,2025
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: Gastroenterology, 2010, Vol.139(4), pp.e5-e7
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 4
    Language: English
    In: Surgical endoscopy, July 2013, Vol.27(7), pp.2526-41
    Description: The aim of this study is to evaluate the most cost-effective treatment strategy using preperitoneal mesh for patients with recurrent inguinal hernia. Currently, the issue of cost-effectiveness is entirely unresolved. A decision analysis was carried out based on the results of a systematic literature review of articles concerning recurrent inguinal hernia repair that were published between 1979 and 2011. A virtual cohort was programmed to undergo three different treatment procedures: (1) laparoscopic totally extraperitoneal hernia repair (TEP), (2) open preperitoneal mesh repair according to Stoppa, and (3) open preperitoneal mesh repair according to Nyhus. We carried out a base-case analysis and varied all variables over a broad range of reasonable hypotheses in multiple one-way and two-way sensitivity analyses. The average cost-effectiveness ratio of Nyhus, Stoppa, and TEP per quality-adjusted life year was US $ ($)1,942, $1,948, and $2,011, respectively. In terms of the incremental cost-effectiveness ratio (ICER), Stoppa was dominated. The choice between TEP or Nyhus procedure depends on the combination of a specific center's rates of recurrence and morbidity as disclosed by three-way sensitivity analysis. Nyhus and TEP repairs are possible optimal choices depending primarily on the institution's rates of recurrence and morbidity. Based on our net benefit-related decision analysis, a hypothetical "fixed budget trade-off" suggests potential annual incremental health system cost savings of $200,000 attained by shifting care for 1,000 patients from TEP to Nyhus repair (depending on clinical end-points, which is a decisive factor).
    Keywords: Decision Trees ; Surgical Mesh ; Hernia, Inguinal -- Economics ; Laparoscopy -- Economics
    ISSN: 09302794
    E-ISSN: 1432-2218
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  • 5
    In: Plastic and Reconstructive Surgery, 2010, Vol.126(4), pp.195e-197e
    Keywords: Breast Neoplasms -- Surgery ; Mastectomy, Segmental -- Methods ; Minimally Invasive Surgical Procedures -- Methods ; Wound Healing -- Physiology;
    ISSN: 0032-1052
    E-ISSN: 15294242
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  • 6
    In: The Indian Journal of Medical Research, 2012, Vol.136(2), p.272-279
    Description: Background & objectives: Ischaemia/reperfusion (I/R) associated with major liver surgery compromises liver function. Ischaemic preconditioning (IPC) may be effective in minimizing hepatic I/R injury. This study aimed to investigate the impact of liver ischaemic manipulations on lipid metabolism in rat during the process of liver recovery after liver surgery. Methods: Sixty three male Wistar rats were assigned to three groups: the sham group, the I/R group which underwent warm ischaemia and reperfusion (I/R), and the IPC group. The animals were subdivided in 3 groups [1st, 3rd and 7th postoperative day (PO)]. Hepatic lipase (HL) and total lipase (TL) activity and the levels of aspartate and alanine transaminases (AST, ALT), triglycerides, HDL and cholesterol were measured in plasma. Results: There was no significant difference in the activity of HL and TL between the groups. Significant higher levels of HDL (P〈0.0001) were observed in the IPC group when compared to the other groups on the 3rd PO day. Triglycerides (P〈0.0001) and HDL (P=0.003) in the IPC group were higher than the sham group on the 7th PO day while HDL was also higher in the I/R group. Significantly higher cholesterol levels were found in the I/R and IPC groups on the 7th PO day, which were not observed in the sham group. There was a similar curve for triglycerides in the sham and IPC groups while there were significantly higher levels of triglycerides on day 7 for the I/R group. The levels of HDL in the IPC group were higher on the 3rd and 7th PO day, compared to day 1. Interpretation & conclusion: Warm ischaemia and I/R injury do not seem to affect lipolytic enzyme activity after the 1st PO day despite the effects on plasma lipids. IPC seems to prevent accumulation of triglycerides and cholesterol in plasma. Key words Hepatic lipase--lipid metabolism--preconditioning--rat liver--warm ischaemia
    Keywords: Cholesterol;
    ISSN: 0971-5916
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  • 7
    In: The Journal of Trauma: Injury, Infection, and Critical Care, 2011, Vol.71(6), pp.E123-E127
    Description: BACKGROUND:: The purpose of this study was to identify which age-related groups of hemodynamically stable blunt trauma patients will present a positive cost-to-benefit ratio, in regard to the screening of incidental findings on Focused Assessment with Sonography for Trauma (FAST). METHODS:: We conducted a prospective study using retrospective data taken from the trauma registry of 6,041 consecutive hemodynamically stable blunt trauma patients who underwent FAST at our Level I urban trauma hospital during the year 2009. A receiver operating characteristic curve was used to determine whether age level is useful in detecting organ-/system-specific incidental findings in trauma patients undergoing FAST and to establish the required diagnostic cutoff value of this selected test. A cost-benefit analysis was then performed for the age-specific cutoff values of each organ/system evaluated by FAST. RESULTS:: We found 522 incidental findings in 468 patients (7.8%). Further diagnostic workup was instructed in 35% (168 of 468) of patients with incidental findings. The cost-benefit analysis for the age-specific cutoff values found in the receiver operating characteristic curve analysis showed that the project of screening for incidental findings on FAST was viable only when the ultrasound operator additionally searches the liver/biliary tree (≥43 years) and the kidneys (≥56 years). CONCLUSIONS:: A systematic examination of the liver and biliary tree and both kidneys of specific age groups during FAST screening of hemodynamically stable blunt trauma patients may disclose a potentially unknown pathology with a positive cost-to-benefit ratio.
    Keywords: Health Care Costs ; Incidental Findings ; Ultrasonography, Doppler -- Economics ; Wounds, Nonpenetrating -- Diagnostic Imaging;
    ISSN: 0022-5282
    E-ISSN: 15298809
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  • 8
    In: British Journal of Medicine and Medical Research, 01/10/2014, Vol.4(36), pp.5756-5769
    Description: Aims: Currently there is not a single conventional marker to reliably assess liver function recovery after hepatectomy. Our aim was to investigate the potential role of circulating lipid levels as markers of liver function recovery. The study was conducted in the experimental laboratory of the Aretaieion Hospital. Methodology: 48 male Wistar rats (240-350 g) were assigned in 2 groups; the sham operated group (A=21) and the 70% hepatectomy group (B=27). There were 3 subgroups according to the day the animals were killed (1st, 3rd and 7th postoperative day [PO]). We measured the levels of AST, ALT, albumin, total protein, triglycerides, HDL and cholesterol in plasma and correlated them with the steps of liver regeneration Results: Significant differences between the groups were observed in the levels of HDL (P=0.001) and cholesterol (P=0.001) on the 1st PO day, and in triglycerides (P=0.045) on the 7th PO day. Conclusion: Cholesterol, and in a lesser degree HDL levels seem to reflect well liver function recovery after hepatectomy. In this experiment they were more sensitive than albumin in assessing the deterioration of liver function as well as the subsequent recovery during regeneration hence they may represent a more accurate marker of liver function. Rise in plasma triglyceride levels reflect the completion of the regenerative process.
    Keywords: Alanine Aminotransferase ; Aspartate Aminotransferase ; Blood Lipids ; High Density Lipoprotein ; Human Diseases ; Liver ; Liver Diseases ; Liver Function ; Serum Albumin ; Surgery ; Triacylglycerols ; Glutamate Pyruvate Transaminase ; Glutamic Pyruvic Transaminase ; Got ; Gpt ; Triglycerides ; Man ; Homo ; Hominidae ; Primates ; Mammals ; Vertebrates ; Chordata ; Animals ; Eukaryotes ; Balkans ; Southern Europe ; Europe ; Developed Countries ; European Union Countries ; Mediterranean Region ; OECD Countries;
    ISSN: British Journal of Medicine and Medical Research
    E-ISSN: 22310614
    Source: CrossRef
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  • 9
    Language: English
    In: International Journal of Surgery, August 2015, Vol.20, pp.35-40
    Description: Intraoperative wound infiltration with local anaesthetic is commonly used. Apart from the obvious immediate action it has been supported that a possible down regulation of pain receptors may lead to longer effects. Our aim was to compare the use of local anaesthetic versus placebo in order to assess if indeed there is a late beneficial effect. We conducted an RCT involving 400 consecutive general surgery patients randomized in 2 groups: Group A = placebo, Group B = wound infiltration with 15 ml of ropivacaine 10%. We recorded the preoperative and postoperative pain for the 1st week as well as the type and quantity of the analgesia used during the study period. No significant difference was found between the groups in all known confounding factors recorded. No significant difference was found in the intensity of postoperative pain. More people of group A required NSAIDs during the first 3 PO days while more people of Group B required stronger painkillers. For those patients who underwent a non urgent operation and especially laparoscopic surgery higher pain score was recorded in the group B from the 3 PO day onwards. Intraoperative local infiltration of the wound with local anaesthetic offers no further benefit for the general surgery apart from that of the immediate PO period. There is no late effect for pain control. Considering that during the immediate postoperative period stronger systematic painkillers are given the intraoperative, infiltration of the wound with the local anaesthetic under study offers no obvious benefit.
    Keywords: Local Anaesthetic ; Wound Infiltration ; Pain ; Determinants of Pain ; Surgery
    ISSN: 1743-9191
    E-ISSN: 1743-9159
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  • 10
    Language: English
    In: The Korean journal of pain, October 2015, Vol.28(4), pp.265-74
    Description: Postoperative (PO) pain interferes with the recovery and mobilization of the surgical patients. The impact of the educational status has not been studied adequately up to now. This prospective study involved 400 consecutive general surgery patients. Various factors known to be associated with the perception of pain including the educational status were recorded as was the preoperative and postoperative pain and the analgesia requirements for the 1(st) PO week. Based on the educational status, we classified the patients in 3 groups and we compared these groups for the main outcomes: i.e. PO pain and PO analgesia. There were 145 patients of lower education (junior school), 150 patients of high education (high school) and 101 of higher education (university). Patients of lower education were found to experience more pain than patients of higher education in all postoperative days (from the 2(nd) to the 6(th)). No difference was identified in the type and quantity of the analgesia used. The subgroup analysis showed that patients with depression and young patients (〈 40 years) had the maximum effect. The educational status may be a significant predictor of postoperative pain due to various reasons, including the poor understanding of the preoperative information, the level of anxiety and depression caused by that and the suboptimal request and use of analgesia. Younger patients (〈 40), and patients with subclinical depression are mostly affected while there is no impact on patients over 60 years old.
    Keywords: Analgesia ; Anxiety ; Depression ; Educational Status ; General Surgery ; Postoperative Pain ; Predictive Value of Tests ; Questionnaires
    ISSN: 2005-9159
    E-ISSN: 20930569
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