Journal of Neuroimmunology, 15 August 2015, Vol.285, pp.156-160
Multiple sclerosis (MS) is associated with Epstein–Barr virus (EBV) infection. A characteristic feature of MS is an intrathecal synthesis of immunoglobulin (Ig)G. In 90 patients with clinically isolated syndromes/early relapsing–remitting MS, serum antibodies to Epstein–Barr nuclear antigen-1, but not to EBV viral capsid antigen, rubella, or varicella zoster virus, were higher ( = 0.03) in those with than those without a calculated intrathecal IgG synthesis 〉 0% and correlated with the percentage (r = 0.27, = 0.009) and concentration (r = 0.27, = 0.012) of intrathecally produced IgG. These findings suggest a link between EBV infection and the events leading to intrathecal IgG synthesis in patients with MS.
Multiple Sclerosis ; Epstein–Barr Virus ; Intrathecal Immunoglobulin G ; Oligoclonal Bands ; Epstein–Barr Nuclear Antigen-1 ; Antibodies ; Medicine ; Anatomy & Physiology
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