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  • Protzel, C.  (56)
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  • 1
    Language: English
    In: European Urology Supplements, August 2012, Vol.11(3), pp.52-59
    Description: Significant advances in molecular medicine have made renal cell carcinoma (RCC) the prototype solid organ malignancy for targeted medical cancer treatment. Theseis new options have made it possible to prolong the life of patients with metastatic disease. However, we are far away from thoroughly understanding the molecular processes of RCC development let alone from being able to cure advanced renal cancer. RCC is the most common renal neoplasia and it remains a very aggressive and often fatal disease. There are several known histologic subtypes of this heterogeneous tumor entity with associated distinct molecular alterations and different clinical outcomes . The clear cell renal cell carcinoma (ccRCC) is the most common and apparently most aggressive RCC subtype with the highest rates of local invasion, metastasis and mortality. It constitutes 70–80% of all renal cancers . It is estimated that more than 30% of patients with RCC have metastatic disease at the time of diagnosis and 30% of organ-confined RCCs will develop metastatic disease after local treatment . Thus, RCC remains a very major challenge. Renal cancer has an increased incidence while mortality remains stable. Advances in molecular characterization of renal cancer have led to a better understanding of the pathogenesis which yet has to translate into improved survival.
    Keywords: Renal Cancer ; Etiology ; Vhl Gene ; Hypermethylation ; Folliculin ; Medicine
    ISSN: 1569-9056
    E-ISSN: 1878-1500
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  • 2
    Language: English
    In: European Urology, December 2016, Vol.70(6), pp.1078-1079
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.eururo.2016.08.035 Byline: Chris Protzel, Oliver W. Hakenberg Author Affiliation: Urology Department, University of Rostock, Rostock, Germany
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
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  • 3
    Language: English
    In: The Journal of Urology, 2001, Vol.166(4), pp.1399-1400
    Description: Byline: CHRIS PROTZEL, JOHANNES B. DAHM, KLAUS J. KLEBINGAT Keywords: ureter; stents; abnormalities Author Affiliation: From the Departments of Urology and Cardiology, Ernst Moritz Arndt University, Greifswald, Germany Article Note: (footnote) Accepted for publication May 18, 2001.
    Keywords: Ureter ; Stents ; Abnormalities ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 4
    Language: English
    In: International Journal of Molecular Sciences, 01 September 2013, Vol.14(10), pp.19494-19505
    Description: Penile cancer is a rare tumor. There is a limited understanding of the biological mediators of prognostic and therapeutic importance in penile cancer. However, there exists some fundamental understanding of the major pathways involved in the development of penile pre-neoplastic lesions and neoplasms. The aim of the present review is to highlight our current state of molecular knowledge in penile cancer to foster the necessary tools for researchers to pave major advancements in our current treatment paradigms and cancer specific outcomes.
    Keywords: Penile Cancer ; Pathways ; Carcinogenesis ; Progression ; Metastasis ; Biology
    ISSN: 1422-0067
    E-ISSN: 1422-0067
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  • 5
    In: BJU International, August 2015, Vol.116(2), pp.196-201
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/bju.13009/abstract Byline: Jared M. Gopman, Rosa S. Djajadiningrat, Adam S. Baumgarten, Patrick N. Espiritu, Simon Horenblas, Yao Zhu, Chris Protzel, Julio M. Pow-Sang, Timothy Kim, Wade J. Sexton, Michael A. Poch, Philippe E. Spiess Keywords: complications; inguinal lymph node dissection; penile cancer Objectives To assess the potential complications associated with inguinal lymph node dissection (ILND) across international tertiary care referral centres, and to determine the prognostic factors that best predict the development of these complications. Materials and Methods A retrospective chart review was conducted across four international cancer centres. The study population of 327 patients underwent diagnostic/therapeutic ILND. The endpoint was the overall incidence of complications and their respective severity (major/minor). The Clavien-Dindo classification system was used to standardize the reporting of complications. Results A total of 181 patients (55.4%) had a postoperative complication, with minor complications in 119 cases (65.7%) and major in 62 (34.3%). The total number of lymph nodes removed was an independent predictor of experiencing any complication, while the median number of lymph nodes removed was an independent predictor of major complications. The American Joint Committee on Cancer stage was an independent predictor of all wound infections, while the patient's age, ILND with Sartorius flap transposition, and surgery performed before the year 2008 were independent predictors of major wound infections. Conclusions This is the largest report of complication rates after ILND for squamous cell carcinoma of the penis and it shows that the majority of complications associated with ILND are minor and resolve without prolonged morbidity. Variables pertaining to the extent of disease burden have been found to be prognostic of increased postoperative morbidity.
    Keywords: Complications ; Inguinal Lymph Node Dissection ; Penile Cancer
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 6
    Language: English
    In: The Journal of Urology, August 2016, Vol.196(2), pp.570-578
    Description: Penile squamous cell carcinoma is a rare but aggressive cancer. Little is known about pivotal events in tumor pathogenesis and metastasis. Lymph node metastasis is the prevailing prognostic factor while clinical detection in patients remains difficult. Our aim was to identify distinct miRNAs that are differentially expressed in metastatic vs nonmetastatic penile carcinoma, which may serve as diagnostic biomarkers for disease progression. TaqMan® arrays and quantitative polymerase chain reaction were applied to analyze miRNA profiles in penile squamous cell carcinoma specimens and glans tissue from 24 patients. The prognostic value of deregulated miRNAs was analyzed using the Kaplan-Meier method. The Spearman test was applied to determine a potential linkage between distinctive miRNAs in individual patients. Loss of miR-1 (p = 0.0048), miR-101 (p = 0.0001) and miR-204 (p = 0.0004) in metastasizing tumors and associated metastases (p = 0.0151, 0.0019 and 0.0003, respectively) distinguished patients with metastatic and nonmetastatic penile squamous cell carcinoma. These 3 miRNAs showed a coherent expression pattern. Consistently, patients with low levels of all 3 miRNAs had worse survival (p = 0.03). We identified a coordinately regulated miRNA target hub that is over expressed in penile squamous cell carcinoma and associated with lymphovascular invasion. Our results provide evidence of a novel multiple miRNA based signature associated with lymph node metastasis and unfavorable prognosis of penile squamous cell carcinoma. The integrated loss of miR-1, miR-101 and miR-204 may predict the formation of metastases in penile cancer at an early stage.
    Keywords: Penile Neoplasms ; Carcinoma, Squamous Cell ; Neoplasm Metastasis ; Micrornas ; Mortality ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 7
    Language: English
    In: European Urology, June 2015, Vol.67(6), pp.e111-e111
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.eururo.2014.12.016 Byline: Oliver W. Hakenberg, Chris Protzel Author Affiliation: Department of Urology, University Hospital Rostock, Rostock, Germany Article History: Accepted 4 December 2014
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
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  • 8
    Language: English
    In: Therapeutic Advances in Urology, June 2012, Vol.4(3), pp.133-138
    Description: Penile cancer is an aggressive disease and after systemic progression it is virtually incurable. While this squamous cell cancer responds to chemotherapy, successful treatment of lymphatic metastases can only be achieved with aggressive surgical treatment in combination with chemotherapy. However, because penile carcinoma is relatively rare there is a paucity of clinical data on the chemotherapy for this aggressive disease. Recent advances have included the establishment of less toxic regimens incorporating taxanes, while cisplatinum remains central to all regimens. Multi-institutional studies are urgently needed to advance the multimodal care for patients with penile cancer.
    Keywords: Penis ; Neoplasm ; Penile Cancer ; Lymph Node ; Metastasis ; Chemotherapy ; Medicine
    ISSN: 1756-2872
    E-ISSN: 1756-2880
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  • 9
    In: Der Klinikarzt, 2017, Vol.46(09)
    In: Der Klinikarzt, 2017, Vol.46(09), pp.430-433
    Description: Die organerhaltende Therapie des Peniskarzinoms erscheint als eine sichere Methodik in der Behandlung des Primärtumors. Sie spielt aufgrund der enormen psychoonkologischen und sozialen Tragweite der Chirurgie am äußeren Genitale eine entscheidende Rolle für die Lebensqualität der Patienten. Die organerhaltende Therapie sollte stadienadaptiert erfolgen. Eine intraoperative Kontrolle der Tumorfreiheit der Schnittränder erscheint effizient.
    ISSN: 0341-2350
    E-ISSN: 1439-3859
    Source: Thieme Publishing Group
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  • 10
    Language: English
    In: European Urology, February 2010, Vol.57(2), pp.e12-e13
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
    Source: ScienceDirect Journals (Elsevier)
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