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  • Shibata, Hiroshi  (20)
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  • 1
    Language: English
    In: Neuroscience Research, Nov, 2014, Vol.88, p.58(9)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.neures.2014.08.002 Byline: Hisanori Tokuda, Masanori Kontani, Hiroshi Kawashima, Yoshinobu Kiso, Hiroshi Shibata, Noriko Osumi Abstract: * ARA and DHA ingestion recovered decreases in hippocampal ARA and DHA in aged rats (82a[bar]85 characters). * ARA ingestion ameliorated an age-dependent decrease in the hippocampal NSPCs number (83a[bar]85 characters). * The number of newborn neurons was correlated with DHA contents in red blood cells (83a[bar]85 characters). * ARA may maintain an NSPC pool, while DHA may support NN production and/or survival (83a[bar]85 characters). Author Affiliation: (a) Institute for Health Care Science, Suntory Wellness Ltd., Osaka, Japan (b) Department of Developmental Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan Article History: Received 8 June 2014; Revised 23 July 2014; Accepted 6 August 2014
    Keywords: Omega 3 Fatty Acids ; Neurosciences ; Arachidonic Acid ; Unsaturated Fatty Acids
    ISSN: 0168-0102
    Source: Cengage Learning, Inc.
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  • 2
    Language: English
    In: Neuroscience Research, November 2014, Vol.88, pp.58-66
    Description: Hippocampal neurogenesis affects learning and memory. We evaluated in rats effects of ingestion of arachidonic acid (ARA) and/or docosahexaenoic acid (DHA) on age-related decreases in proliferating neural stem/progenitor cells (NSPCs) or newborn neurons (NNs). Rats were fed with ARA- and/or DHA-containing diet from 2 to 18 months old and then sacrificed 1 day or 4 weeks after 5-bromo-2-deoxyuridine (BrdU) injections at 2, 6 and 18 months. The numbers of NSPCs (SOX2+/BrdU+) and NNs (NeuN+/BrdU+) were determined immunohistochemically. The number of BrdU+ cells 1 day after BrdU injections decreased with age, but increased 65% after ARA ingestion compared to the control at 18 months. The SOX2+/BrdU+ cell ratio was unchanged by aging or ingestion of ARA or DHA. The number of NeuN+/BrdU+ cells 4 weeks after BrdU injections decreased with age, but increased 34% (yet not statistically significant) after DHA ingestion compared to the control at 18 months. These results indicate that ARA ingestion can ameliorate the age-related decrease in the number of NSPCs in rats. The functions of ARA and DHA in hippocampal neurogenesis appear to be different in aged rats; ARA may maintain an NSPC pool, whereas DHA may support NN production and/or survival.
    Keywords: Hippocampal Neurogenesis ; Neural Stem Cell ; Arachidonic Acid ; Docosahexaenoic Acid ; Aging ; Medicine ; Anatomy & Physiology
    ISSN: 0168-0102
    E-ISSN: 1872-8111
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  • 3
    Language: English
    In: The Tohoku journal of experimental medicine, September 2016, Vol.240(1), pp.31-7
    Description: Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients for normal brain development. The principal dietary n-6 and n-3 PUFAs are linoleic acid (LA) and α-linolenic acid (ALA), respectively, We have previously shown that maternal dietary imbalance between these PUFAs, i.e., rich in LA and poor in ALA, affected brain development and increased anxiety-related behavior in the mouse offspring. Here we further addressed sex difference in anxiety-related behavior in the offspring exposed to maternal LA:ALA imbalance. We fed pregnant mice a LA excess/ALA deficient (LA(ex)/ALA(def)) diet, and raised their offspring on a well-balanced LA:ALA diet from an early lactation period. When the offspring were grown to adulthood, they were subjected to behavioral and biochemical analyses. We found that both male and female offspring exposed to the LA(ex)/ALA(def) diet showed increased anxiety-related behavior compared to those exposed to the control diet, which was differently observed between the sexes. The female offspring also exhibited hyperactivity by maternal intake of the LA(ex)/ALA(def) diet. On the other hand, abnormal depressive behavior was undetected in both sexes. We also found that the ratio of n-6 to n-3 PUFAs in the brain was unaffected regardless of maternal diet or offspring's sex. Since the n-6/n-3 ratio is known to influence emotional behavior, it is reasonable to assume that LA:ALA imbalance exposed during brain development is the key for causing enhanced anxiety in adulthood. The present study indicates that maternal dietary imbalance between LA and ALA increases offspring's anxiety-related behavior with a sex-dependent manner.
    Keywords: Maternal Nutritional Physiological Phenomena ; Sex Characteristics ; Anxiety -- Physiopathology ; Linoleic Acid -- Metabolism ; Alpha-Linolenic Acid -- Metabolism
    ISSN: 00408727
    E-ISSN: 1349-3329
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  • 4
    In: STEM CELLS, February 2016, Vol.34(2), pp.470-482
    Description: Omega‐6 (‐6) and omega‐3 (‐3) polyunsaturated fatty acids (PUFAs) are essential nutrients. Although several studies have suggested that a balanced dietary ‐6:‐3 ratio is essential for brain development, the underlying cellular and molecular mechanism is poorly understood. Here, we found that feeding pregnant mice an ‐6 excess/‐3 deficient diet, which reflects modern human diets, impairsed neocortical neurogenesis in the offspring. This impaired neurodevelopment occurs through a precocious fate transition of neural stem cells from the neurogenic to gliogenic lineage. A comprehensive mediator lipidomics screen revealed key mediators, epoxy metabolites, which were confirmed functionally using a neurosphere assay. Importantly, although the offspring were raised on a well‐balanced ‐6:‐3 diet, they exhibited increased anxiety‐related behavior in adulthood. These findings provide compelling evidence that excess maternal consumption of ‐6 PUFAs combined with insufficient intake of ‐3 PUFAs causes abnormal brain development that can have long‐lasting effects on the offspring's mental state. S C Omega‐6 and omega‐3 polyunsaturated fatty acids are essential nutrients. Although several studies have suggested that a balanced dietary omega‐6:omega‐3 ratio is essential for normal brain development, the underlying cellular and molecular mechanism is poorly understood. Here we shows that maternal consumption of an omega‐6 rich/omega‐3 poor diet impairs offspring's neocortical neuronal layer formation, and reveals its cellular and molecular mechanism; epoxy metabolites of omega‐6 and omega‐3 regulate the fate of neural stem cells (NSCs). We also show that these offspring demonstrate increased anxiety‐related behavior. Our results raise important concerns regarding the increased consumption of such a modern diet, particularly during pregnancy.
    Keywords: Neural Stem Cells ; Arachidonic Acid ; Docosahexaenoic Acid ; Epoxides ; Anxiety ; Metabolomics
    ISSN: 1066-5099
    E-ISSN: 1549-4918
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  • 5
    Language: English
    In: Stem Cells, Feb, 2016, Vol.34(2), p.470(14)
    Keywords: Metabolites ; Omega 6 Fatty Acids ; Pregnant Women ; Epoxy Resins ; Brain ; Omega 3 Fatty Acids ; Stem Cells ; Unsaturated Fatty Acids
    ISSN: 1066-5099
    Source: Cengage Learning, Inc.
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  • 6
    Language: Japanese
    In: 食品衛生学雑誌, 2014, Vol.55(2), pp.117-134
    Description: ガラス製,陶磁器製またはホウロウ引きの器具・容器包装,ならびに金属缶のカドミウム(Cd)および鉛(Pb)溶出試験における各測定法の性能を評価するため,試験室間共同試験を行った.当試験には17機関が参加し,濃度非明示の8濃度16検体についてフレーム方式原子吸光光度法(AAS),電気加熱方式原子吸光光度法(GF-AAS),誘導結合プラズマ発光強度測定法(ICP-OES)および誘導結合プラズマ質量分析法(ICP-MS)によりCdおよびPbの定量を行った.その結果,AAS,ICP-OESおよびICP-MS(内標法)では真度が93~105%,併行精度(RSD〈sub〉r〈/sub〉)が0.7~8.4%,室間再現精度(RSD〈sub〉r〈/sub〉)が2.6~19.3%であり,規格試験法として十分な性能を有していることが判明した.一方,GF-AASではいくつかの結果でRSD〈sub〉r〈/sub〉が10%を超えており,適切な精度管理が必要であった.
    Description: An interlaboratory study was performed to evaluate a migration test method of cadmium (Cd) and lead (Pb), based on the Japanese Food Sanitation Law for glassware, ceramicware, enamelware and metal cans. Seventeen laboratories participated, and quantified Cd and Pb in eight test solutions as blind duplicates using flame atomic absorption spectrometry (AAS), graphite furnace atomic absorption spectrometry (GF-AAS), inductively coupled plasma-optical emission spectrometry (ICP-OES) or induced coupled plasma-mass spectrometry (ICP-MS). Statistical analysis revealed that the trueness, repeatability (RSD〈sub〉r〈/sub〉) and reproducibility (RSD〈sub〉r〈/sub〉) were 93–105%, 0.7–8.4% and 2.6–19.3% by using AAS, ICP-OES and ICP-MS (internal standard method). The performance of these methods is sufficient for testing specifications. However, some of the RSD〈sub〉r〈/sub〉 values exceeded 10% in GF-AAS, and careful control of accuracy is required.
    Keywords: カドミウム ; 鉛 ; 溶出試験 ; 原子吸光光度法 ; 誘導結合プラズマ発光強度測定法 ; 誘導結合プラズマ質量分析法 ; 試験室間共同試験 ; Cadmium ; Lead ; Migration Test ; Atomic Absorption Spectrometry ; Induced Coupled Plasma-Optical Emission Spectrometry ; Induced Coupled Plasma-Mass Spectrometry ; Interlaboratory Study
    ISSN: 0015-6426
    E-ISSN: 18821006
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  • 7
    Language: English
    In: Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2014, Vol.55(6), pp.269-278
    Description: Based on the Japanese Food Sanitation Law, the performances of official and alternative material test methods for cadmium (Cd) and lead (Pb) in food contact plastics were compared. Nineteen laboratories participated to an interlaboratory study, and quantified Cd and Pb in three PVC pellets. in the official method, a sample is digested with H2SO4, taken up in HCl, and evaporated to dryness on a water bath, then measured by atomic absorption spectrometry (AAS) or inductively coupled plasma-optical emission spectrometry (ICP-OES). Statistical treatment revealed that the trueness, repeatability (RSDr) and reproducibility (RSDr) were 86-95%, 3.1-9.4% and 8.6-22.1%, respectively. The values of the performance parameters fulfilled the requirements , and the performances met the test specifications. The combination of evaporation to dryness on a hot plate and measurement by AAS or ICP-OES is applicable as an alternative method. However, the trueness and RSDr were inferior to those of the official method. The performance parameters obtained by using the microwave digestion method (MW method) to prepare test solution were better than those of the official method. Thus, the MW method is available as an alternative method. Induced coupled plasma-mass spectrometry (ICP-MS) is also available as an alternative method. However, it is necessary to ensure complete digestion of the sample.
    Keywords: Public Health;
    ISSN: 0015-6426
    E-ISSN: 1882-1006
    Source: CrossRef
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  • 8
    Language: English
    In: Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2015, Vol.56(3), pp.123-131
    Description: Using six kinds of zinc solution in water and 4% acetic acid as samples, an interlaboratory study was performed to evaluate a zinc (Zn) test method for food-contact rubber products, based on the Japanese Food Sanitation Law. Eighteen laboratories participated, and quantified Zn in six test solutions as blind duplicates using flame atomic absorption spectrometry, induced coupled plasma-optical emission spectrometry or induced coupled plasma-mass spectrometry. Statistical analysis revealed that the trueness, repeatability (RSDr) and reproducibility (RSDr) were 97-103%, 0.7-4.9% and 1.7-8.9% by all measuring methods. The values of the performance parameter fulfilled the target value (trueness: 80-110%, RSDr: 10%, RSDr: 25%). The performance of these methods is sufficient for testing the adherence of samples to the specifications.
    Keywords: Public Health;
    ISSN: 0015-6426
    E-ISSN: 1882-1006
    Source: CrossRef
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  • 9
    Language: Japanese
    In: 食品衛生学雑誌, 2016, Vol.57(5), pp.169-178
    Description: 〈p〉食品衛生法におけるポリスチレン製器具・容器包装の揮発性物質試験の性能を評価するため,ポリスチレン,アクリロニトリル・スチレン共重合樹脂,アクリロニトリル・ブタジエン・スチレン共重合樹脂のペレットを検体として試験室間共同試験を行った.当試験には21機関が参加し,3検体(各2測定)について規制対象であるスチレン,トルエン,エチルベンゼン,イソプロピルベンゼンおよびプロピルベンゼンの含有量をGC-FID,GC-MSおよびヘッドスペース(HS)-GCにより定量した.GC-FIDを用いた方法による併行精度(RSDr)は1.0~2.6%,室間再現精度(RSDr)は2.5~5.8%であり,その性能は目標値を満たしており,規格試験法として十分であった.GC-MSにおけるRSDrは1.4~7.8%,RSDrは4.9~13%,HS-GCにおけるRSDrは2.0~2.6%,RSDrは3.3~6.9%であり,それらの定量値はGC-FIDとほぼ同等であった.そのため,これらは規格試験法の代替法として適用可能であった.〈/p〉
    Description: 〈p〉Using polystyrene, acrylonitrile-styrene resin and acrylonitrile–butadiene–styrene resin pellets as samples, an interlaboratory study was performed to evaluate the volatiles test method, based on the specifications described in the Japanese Food Sanitation Law for food-contacting polystyrene products. The study was conducted with the participation of twenty-one laboratories. Each laboratory quantified the contents of styrene, toluene, ethylbenzene, isopropylbenzene and propylbenzene in three test pellets using GC-FID, GC-MS or headspace-GC-FID. Statistical analysis revealed that the repeatability (RSDr) and reproducibility (RSDr) were 1.0–2.6 and 2.5–5.5% for the GC-FID method. The values of the performance parameters fulfilled the requirements (RSDr: 10%, RSDr: 25%), and the performance is sufficient for specifications testing. The RSDr and RSDr of results obtained using the GC-MS and HS-GC methods were 1.4–7.8 and 4.9–13%(GC-MS), and 2.0–2.6 and 3.3–6.9%(HS-GC-FID), respectively. The quantified levels were similar to those obtained with GC-FID. The study suggests that the GC-MS and HS-GC methods can be employed as alternative methods to the GC-FID method.〈/p〉
    Keywords: 器具・容器包装 ; ポリスチレン ; 揮発性物質 ; エチルベンゼン ; スチレン ; ガスクロマトグラフィー ; ヘッドスペースガスクロマトグラフィー ; 試験室間共同試験 ; Food Contact Utensils And Packages ; Polystyrene ; Volatile Substance ; Ethylbenzene ; Styrene ; Gc ; Headspace Gc ; Interlaboratory Study
    ISSN: 0015-6426
    E-ISSN: 18821006
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  • 10
    Language: Japanese
    In: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 2016, Vol.57(5), pp.169-178
    Description: Using polystyrene, acrylonitrile-styrene resin and acrylonitrile-butadiene-styrene resin pellets as samples, an interlaboratory study was performed to evaluate the volatiles test method, based on the specifications described in the Japanese Food Sanitation Law for food-contacting polystyrene products. The study was conducted with the participation of twenty-one laboratories. Each laboratory quantified the contents of styrene, toluene, ethylbenzene, isopropylbenzene and propylbenzene in three test pellets using GC-FID, GC-MS or headspace-GC-FID. Statistical analysis revealed that the repeatability (RSDr) and reproducibility (RSDr) were 1.0-2.6 and 2.5-5.5% for the GC-FID method. The values of the performance parameters fulfilled the requirements (RSDr: 10%, RSDr: 25%), and the performance is sufficient for specifications testing. The RSDr and RSDr of results obtained using the GC-MS and HS-GC methods were 1.4-7.8 and 4.9-13%(GC-MS), and 2.0-2.6 and 3.3-6.9%(HS-GC-FID), respectively. The quantified levels were similar to those obtained with GC-FID. The study suggests that the GC-MS and HS-GC methods can be employed as alternative methods to the GC-FID method.
    Keywords: Cooking and Eating Utensils ; Food Packaging ; Acrylic Resins -- Chemistry ; Butadienes -- Chemistry ; Gas Chromatography-Mass Spectrometry -- Methods ; Polystyrenes -- Chemistry ; Volatile Organic Compounds -- Analysis
    E-ISSN: 1882-1006
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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