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  • Singh, A.
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  • 1
    Language: English
    In: Science (New York, N.Y.), 25 January 2013, Vol.339(6118), pp.446-8
    Description: The human genome contains ~50 genes that were derived from transposable elements or transposons, and many are now integral components of cellular gene expression programs. The human THAP9 gene is related to the Drosophila P-element transposase. Here, we show that human THAP9 can mobilize Drosophila P-elements in both Drosophila and human cells. Chimeric proteins formed between the Drosophila P-element transposase N-terminal THAP DNA binding domain and the C-terminal regions of human THAP9 can also mobilize Drosophila P elements. Our results indicate that human THAP9 is an active DNA transposase that, although "domesticated," still retains the catalytic activity to mobilize P transposable elements across species.
    Keywords: DNA Transposable Elements ; Transposases -- Genetics
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 2
    Language: English
    In: Tetrahedron Letters, 15 May 2013, Vol.54(20), pp.2525-2527
    Description: Adenine was formed when an aqueous solution of CH COONH /NH HCO was subjected to mass spectrometer/refluxed for 72 h/heated in a closed vessel for a long time. Since these salts are sources of CO and NH and H O is available from the reaction medium, adenine might get formed by the combination of CO , H O and NH . The occurrence of this reaction in the gas phase as well as in the aqueous phase points towards the possibility of similar reactions during the primitive earth conditions.
    Keywords: Adenine ; Gas Phase Reactions ; Mass Spectrometer ; Solution Phase Reaction ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 3
    Language: English
    In: Food Chemistry, 15 April 2013, Vol.137(1-4), pp.62-67
    Description: ► Higher level of sitosterol was found to limit polymerization in frying oils. ► A corresponding increase in the extent of TG ester hydrolysis was observed. ► Conjugation in steradienes may be responsible for the antioxidative effect. ► Atmospheric moisture may catalyze the conversion of sterol to steradiene. ► Sitosterol was found was more potent than sitostanol in limiting TG polymerization. The antioxidative effect of sitosterol at 1, 2 and 5% levels, in triolein, refined canola, high oleic sunflower and flaxseed oils, continuously heated for a period of up to 72 h at frying temperature of 180 °C, was studied. High Pressure Size Exclusion Chromatography (HPSEC) was used to monitor changes in peak areas of triacylglycerol (TG) polymer, monomer and ester hydrolysis products. The presence of enhanced levels of sitosterol was found to significantly decrease TG polymer formation in triolein and the vegetable oil samples after heating at 180 °C for a period of 72 h. A corresponding increase in the level of intact TG monomer and the extent of TG ester hydrolysis was observed in all samples with enhanced levels of sitosterol. Conversion of sterol to steradiene, by the 1, 2 elimination of water, may be responsible for the antioxidative effect of sitosterol at frying temperatures.
    Keywords: Vegetable Oils ; Frying ; Tg Polymer ; Sitosterol ; Steradiene ; Antioxidant ; Chemistry ; Diet & Clinical Nutrition ; Economics
    ISSN: 0308-8146
    E-ISSN: 1873-7072
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  • 4
    Language: English
    In: Journal of Hydrology, 2011, Vol.406(3), pp.245-255
    Description: ► Various alternatives are evaluated to mitigate the problem of waterlogging. ► Rice crop should be replaced by ‘sorghum’ to overcome the problem of waterlogging. ► The lining of canal irrigation systems is recommended to reduce seepage rates. ► The policies should be implemented in such a way that achieves long-term goals. Accurate estimation of the groundwater recharge is essential for efficient and sustainable groundwater management in arid and semi-arid regions, as water resources are critical to economic development in these areas. Various techniques are available to quantify recharge. The hydrological budget model proposed herein is unique, simple, and easy to apply. It uses data on groundwater level, groundwater extraction, and distributed specific yield information for estimating groundwater recharge. The Model is employed to estimate the seasonal long-term (35 years, e.g., from 1974 to 2009) groundwater recharge of an irrigated semi-arid area located in Haryana State of India, where groundwater levels are rising, continuously. The results are analysed to provide an overview of the process dynamics that led to imbalance of the system. Groundwater recharge analysis during the study period reveals that percolation from irrigated fields is the main recharge component with 49% contribution to the total recharge. An annual groundwater table rise of 0.14 m has been estimated for the study area. Various are evaluated to mitigate the problems of waterlogging and salinisation, considering the socio-economic issues which have wider policy significance on sustainability. Several suitable water management strategies such as reduction in rice area, increase in pumping volume and using the groundwater conjunctively with higher quality canal water, and lining of canal networks are suggested to bring the watertable down to a safe limit and to prevent further rising of the watertable. Among the potential solution alternatives studied, the one which considers 10% reduction in rice area along with 2% increase in pumping volume and 20% canal lining, yields best result for mitigating the waterlogging problems.
    Keywords: Groundwater Recharge ; Groundwater Management ; Waterlogging ; Water Balance ; Hydrologic Budget ; Geography
    ISSN: 0022-1694
    E-ISSN: 1879-2707
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  • 5
    Language: English
    In: Journal of the American Chemical Society, 27 May 2015, Vol.137(20), pp.6464-7
    Description: The presence of antimony, as a dopant in the colloidal growth reaction for CuIn(1-x)Ga(x)S2 (CIGS) nanocrystals, causes end-to-end fusion of nanorod pairs into nanodumbbells at high yield. The influence of the dopant on shape is indirect; antimony catalyzes the incorporation of gallium, which is found in high concentration at the junction between the fused nanorods.
    Keywords: Copper Compounds – Chemical Properties ; Catalysis – Research ; Gallium – Chemical Properties;
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 6
    Language: English
    In: Computers in Human Behavior, January 2016, Vol.54, pp.290-300
    Description: Challenged by competitive pressures, and enabled by information technologies (IT), organizations are forming strategic partnerships that share, collaborate, and make collective decisions across the supply chain (SC). To study this phenomenon, researchers have focused on one or some of these five salient factors: Information Technology Integration (IT), Inter-organizational Trust (TR), Relational Governance (RG), Transaction Cost (TC), and Supply Chain Performance (PE). In this study, we develop a research model that includes all these five factors by synthesizing and integrating theoretical perspectives: transaction cost economics, and relational governance. Our theoretical model clarifies the intricate relationships between the five factors by positioning two common resources for the supply chain: Inter-organizational Trust and IT, as the independent variables that influence outcome measures: performance, and reduction in transaction costs. Relational governance, which facilitates joint decision making, is theorized as playing a central role between the resources and the outcome measures. Data collected from 167 purchasing and supply chain managers provides strong support to our research model. Our findings should help researchers as well as practitioners to develop a more complete and transparent understanding of the relevant mechanisms with which the partnership resources, exert their beneficial effects on supply chain outcomes.
    Keywords: Trust ; Relational Governance ; Inter-Organizational Information Systems ; Supply Chain Performance ; Transaction Cost ; Computer Science ; Psychology
    ISSN: 0747-5632
    E-ISSN: 1873-7692
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  • 7
    Language: English
    In: Biophysical Journal, 05 September 2012, Vol.103(5), pp.1087-1096
    Description: Homogeneous cell populations can exhibit considerable cell-to-cell variability in protein levels arising from the stochastic nature of the gene-expression process. In particular, transcriptional bursting of mRNAs from the promoter has been implicated as a major source of stochasticity in the expression of many genes. In eukaryotes, transcribed pre-mRNAs have to be exported outside the nucleus and in many cases, export rates can be slow and comparable to mRNA turnover rates. We investigate whether such export processes can be effective mechanisms in buffering protein levels from transcriptional bursting of pre-mRNAs in the nucleus. For a stochastic gene-expression model with both transcriptional bursting and export, we derive an exact solution of the steady-state probability-generating function for both the nuclear and the cytoplasmic mRNA levels. These formulas reveal that decreasing export rates can dramatically reduce variability in cytoplasmic mRNA levels. However, our results also show that decreasing export rates enhance mRNA autocorrelation times, which function to increase heterogeneity in protein levels. Our overall analysis concludes that under physiologically relevant parameter regimes, a pre-mRNA export step can decrease steady-state variability at the mRNA level but not at the protein level. Finally, we reinforce previous observations that saturation in the pre-mRNA transport machinery can be an important mechanism in suppressing protein variability from underlying transcriptional bursts.
    Keywords: Biology
    ISSN: 0006-3495
    E-ISSN: 1542-0086
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  • 8
    In: International Journal of Geriatric Psychiatry, June 2013, Vol.28(6), pp.654-655
    Description: Byline: Arun Singh, George S. Alexopoulos ***** No abstract is available for this article. *****
    Keywords: Antidepressants ; Depression (Mood disorder);
    ISSN: 0885-6230
    E-ISSN: 1099-1166
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  • 9
    Language: English
    In: Journal of Applied Physics, 15 January 2011, Vol.109(2)
    Description: Results on two series of lead-free piezoelectric solid solutions of 1 − x − y ( Bi 0.5 Na 0.5 ) TiO 3 − x ( Bi 0.5 K 0.5 TiO 3 ) − y ( Na 0.5 K 0.5 ) NbO 3 (BNT-BKT-KNN) ceramics, synthesized in the vicinity of ferroelectric rhombohedral ( x = 0.17 ) and ferroelectric tetragonal ( x = 0.20 ) phase boundary of 1 − x ( BNT ) – xBKT are presented. Orthorhombic KNN in stoichiometric proportion as third component with 0.0 ≤ y ≤ 0.06 is added to prepare these two series (i) with x = 0.17 and (ii) with x = 0.20 . Addition of KNN up to a critical y is observed to improve tetragonality in both series and solid solubility of KNN was verified at least up to y = 0.1 in this system. Depolarization temperature T d of these stoichiometric BNT-BKT-KNN series were found to be considerably lower than that of their parent BNT-BKT compositions. As a result of this, coexistence of polar and nonpolar phases for compositions at morphotropic phase boundary (MPB) were indicated at room temperature, resulting in pinched polarization versus electric field ( P - E ) loops and large strain (strain of ∼ 0.80 % was observed for y = 0.01 sample in ×20 series and strain of 0.50% was seen for y = 0.04 sample in ×17 series) The MPB of ×17 and ×20 series found to be at y = 0.04 and y = 0.01 , respectively.
    Keywords: Articles
    ISSN: 0021-8979
    E-ISSN: 1089-7550
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  • 10
    Language: English
    In: Journal of General Internal Medicine, 2012, Vol.27(12), pp.1721-1721
    Description: An elderly male with metastatic pancreatic adenocarcinoma and no prior history of pedal edema presented with painful, confluent, macular erythema on bilateral lower extremities with grade III lower extremity edema for 1 week following two cycles of gemcitabine. He was afebrile with local warmth and tenderness and a total leukocyte count of 5000 cells/mm3. An initial diagnosis of cellulitis was made after a negative Doppler ultrasound for DVT was completed. The patient was started on cefazolin. However, failure of the antibiotic trial and absent systemic manifestations led to the presumptive diagnosis of gemcitabine associated pseudocellulitis. The symptoms promptly resolved with withdrawal of the offending agent (Fig. 1).
    Keywords: Medicine;
    ISSN: 0884-8734
    E-ISSN: 1525-1497
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