Tetrahedron Letters, 08 January 2014, Vol.55(2), pp.525-527
A simple, green, and efficient protocol is reported for the preparation of aryl-7,8-dihydro[1,2,4]triazolo[4,3- ]-pyrimidine-6-carbonitriles through one-pot multi component reaction using substituted aromatic aldehydes, malononitrile, and 3-amino[1,2,4]triazole. The reaction is catalyzed by boric acid in aqueous micellar condition. Present protocol incorporates environmentally non-hazardous reaction condition, easy work-up, and use of recyclable catalytic system with associated benefits like excellent yield (84–96%) and shorter reaction time (20 min). Proposed methodology offers rapid access to substituted aryl-7,8-dihydro[1,2,4]triazolo[4,3- ]pyrimidine-6-carbonitriles with high atom-economy and catalytic efficiency.
Triazolopyrimidine ; Boric Acid ; Aqueous Micellar Medium ; Atom Economy ; Chemistry
View record in ScienceDirect (Access to full text may be restricted)