Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Stenzl, Arnulf  (18)
Type of Medium
Language
Year
  • 1
    Language: English
    In: The Journal of Urology, April 2012, Vol.187(4), pp.e535-e535
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
  • 3
    Language: English
    In: The Journal of Urology, April 2018, Vol.199(4), pp.e366-e366
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
  • 5
    In: BJU International, February 2012, Vol.109(4), pp.634-638
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1464-410X.2011.10392.x Keywords: renal cell carcinoma (RCC); XPA-210; proliferation; oncocytoma; biomarker; thymidine kinase 1 Abstract: What's known on the subject? and What does the study add? The exposed proliferation antigen 210 (XPA-210) of the proliferation marker thymidine kinase 1 (TK1) showed higher expression levels in metastatic renal cell carcinoma. The current study used a new XPA-210 antibody to clarify the role of TK1 tissue expression in the largest reported cohort of different renal cell carcinoma types and oncocytomas. OBJECTIVE To determine the clinical role of the exposed proliferation antigen 210 (XPA-210) of the proliferation marker thymidine kinase 1 (TK1) in a large cohort of different renal cell carcinoma (RCC) types, oncocytomas and normal renal tissues samples, as TK1 is reported to be of clinical significance in several cancer entities and is suggested as a prognostic serum biomarker for RCC. PATIENTS AND METHODS Expressions of XPA-210 were determined immunohistochemically in 40 clear cell RCCs (ccRCC), 25 papillary RCCs (papRCC), 17 chromophobe RCC (chRCC), 27 oncocytomas and 64 normal renal parenchyma paraffin-embedded specimens. Immunohistochemistry was performed with a monoclonal anti-XPA-210 antibody. Staining was measured by the percentage of positive cells. Expression was compared between subgroups and correlated with respective clinical data using one-way analysis of variance with post hoc Tukey-Kramer analyses. RESULTS XPA-210 staining in the RCC subgroup was significantly different from the oncocytomas (mean [ sem] 4.1 [0.4] vs 2.2 [0.4]; P = 0.004) and from normal renal tissue (1.0 [0.1]; P 〈 0.001], whereas oncocytomas did not differ from normal renal parenchyma staining (P = 0.18). Subdivided into RCC groups, only ccRCC (mean [ sem] 5.1 [0.6]; P 〈 0.001) and papRCC (4.4 [0.6]; P 〈 0.001) varied from normal renal parenchyma, whereas chRCC (1.4 [0.3]; P = 0.99) did not. RCC XPA-210 staining was significantly associated with higher tumour stage (T = 3, P = 0.002) and grade (G = 3, P = 0.001). CONCLUSIONS The malignant character of RCC is reflected by higher XPA-210 expression as compared with oncocytomas and normal kidney. The ccRCC and papRCC subgroups had higher XPA-210 levels. XPA-210 could be considered a potential marker for the assessment of the proliferative activity in primary RCC. Author Affiliation: (1)Departments of Urology (*)Pathology, Eberhard-Karls University, Tuebingen, Germany ([dagger])Alere North America, Inc., San Diego, CA, USA Article History: Accepted for publication 16 March 2011 Article note: Christian Schwentner, Department of Urology, Eberhard-Karls University Tuebingen, Hoppe-Seyler Strasse 3, 72076 Tuebingen, Germany. e-mail: Christian.schwentner@med.uni-tuebingen.de
    Keywords: Renal Cell Carcinoma Rcc ; Xpa‐210 ; Proliferation ; Oncocytoma ; Biomarker ; Thymidine Kinase 1
    ISSN: 1464-4096
    E-ISSN: 1464-410X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: Anticancer research, November 2011, Vol.31(11), pp.3783-8
    Description: To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. The expressions of PTEN, p-Akt and p27(Kip1) were immunohistochemically assessed in 17 teratomas, 27 embryonal cell carcinomas, 6 yolk sac tumors and 24 benign testicular parenchymas. The cytoplasmic and corresponding nuclear expressions were compared and correlated to tumor entity. PTEN was dramatically reduced in all the NST subgroups. Concentrated nuclear p27(Kip1) and loss of the cytoplasmic form was found in teratomas and embryonal cell carcinomas. Neither altered expression nor negative Akt regulation was found. The yolk sac tumors showed late cytoplasmic shift of PTEN and p27(Kip1). Both, the absence of overexpression of p-Akt and of negative correlations to PTEN and p27(Kip1) suggest that signalling of these parameters in NST might include additional mechanisms such as crosstalk to other pathways rather than classical Akt activation.
    Keywords: Cyclin-Dependent Kinase Inhibitor P27 -- Metabolism ; Neoplasms, Germ Cell and Embryonal -- Metabolism ; Pten Phosphohydrolase -- Metabolism ; Proto-Oncogene Proteins C-Akt -- Metabolism ; Testicular Neoplasms -- Metabolism
    E-ISSN: 1791-7530
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: European Journal of Radiology, 2011, Vol.79(2), pp.189-195
    Description: To evaluate the value of T2w endorectal MRI (eMRI) for correct detection of tumor foci within the prostate regarding tumor size. 70 patients with histologically proven prostate cancer were examined with T2w eMRI before radical prostatectomy at a 1.5 T scanner. For evaluation of eMRI, two radiologists evaluated each tumor focus within the gland. After radical prostatectomy, the prostates were prepared as whole-mount sections, according to transversal T2w eMRI. For each slice, tumor surroundings were marked and compared with eMRI. Based on whole-mount section, 315 slices were evaluated and 533 tumor lesions were documented. Based on the T2w eMRI, 213 tumor lesions were described. In 137/213, histology could prove these lesions. EMRI was able to visualize 0/56 lesions with a maximum size of 〈0.3 cm (detection rate 0%), between 0.3 and 0.5 cm 4/116 (3%), between 1 and 0.5 cm 22/169 (13%), between 2 and 1 cm 61/136 (45%) and for 〉2 cm 50/56 (89%). False positive eMRI findings were: 〈0.3 cm = 0, 0.5–0.3 cm = 12, 0.5–1 cm = 34, 1–2 cm = 28 and 〉2 cm = 2. T2w eMRI cannot exclude prostate cancer with lesions smaller 10 mm and 0.4 cm respectively. The detection rate for lesions more than 20 mm (1.6 cm ) is to be considered as high.
    Keywords: Endorectal Mri ; Detection Rate ; Prostate Cancer ; T2w Mri ; Tumor Size ; Whole-Mount Specimens ; Medicine
    ISSN: 0720-048X
    E-ISSN: 1872-7727
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: World Journal of Urology, 2013, Vol.31(2), pp.351-358
    Description: BACKGROUNDGalactin-3 is a cell adhesion molecule involved in tumor progression. Our aim was to examine Gal-3 expression in tumor, benign tissue adjacent to the tumor (adjacent-benign) and benign prostate specimens and correlated it with biochemical recurrence. MATERIALS AND METHODSTissue microarrays were prepared from 83 tumor, 78 adjacent-benign and 75 benign tissues obtained from 83 patients undergoing prostatectomy for clinically localized prostate cancer. Tissues were stained using a Gal-3 antibody and immunohistochemistry. The staining was graded between 0 and 300 depending upon staining intensity and the area of staining. In 37 patients on whom there was follow-up (Mean: 57.8 months; Median: 68 months), staining intensity was correlated with biochemical recurrence. RESULTSGal-3 showed both nuclear and cytoplasmic localization in benign, adjacent-benign and tumor tissues. Median Gal-3 staining scores significantly decreased from benign (192.5) to adjacent-benign (148.8 p = 0.007) and to tumor (108.8; p 〈 0.0001) tissues. In univariate analysis, age (p = 0.028), Gleason sum (p = 0.007), T stage (p = 0.011), seminal vesicle invasion (p = 0.009), pre-operative prostate-specific antigen (p = 0.045) and Gal-3 staining in tumor tissues (0.018) significantly correlated with biochemical recurrence. In multivariate analysis, Gal-3 expression in tumor (p = 0.04), adjacent-benign (p = 0.037) and benign (p = 0.005) tissues significantly correlated with biochemical recurrence. Gal-3 staining in tumor tissues had 91.7 % sensitivity, 64 % specificity and 73 % accuracy in predicting biochemical recurrence. CONCLUSIONSThis is the first study that showed a decreasing gradient of Gal-3 expression in benign, adjacent-benign and tumor tissues. Gal-3 expression may be useful in predicting biochemical recurrence.
    Keywords: Galectin-3 ; Biochemical recurrence ; Prostate cancer ; Tissue microarray
    ISSN: 0724-4983
    E-ISSN: 1433-8726
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: Anticancer research, October 2012, Vol.32(10), pp.4339-45
    Description: To investigate the expression of the KIT/stem cell factor (SCF) axis in different renal cell carcinoma subtypes with regard to targeted therapies. The expression of KIT and SCF were immunhistochemically assessed in 40 clear cell (ccRCC), 25 papillary (pRCC) and 19 chromophobe carcinomas (chRCC); 27 oncocytomas and 32 benign kidney parenchyma specimens differentiated into distal tubules (DT) and proximal tubules (PT). The expression of KIT was significantly higher in chRCC and oncocytoma compared to ccRCC and pRCC. All tumours exhibited a significant increase of membranous to cytoplasmic KIT expression, with the highest in ccRCC and pRCCs. SCF was expressed in all tumour subgroups, with the highest in oncocytomas and pRCC. SCF correlated positively with the cytoplasmic expression of KIT. A higher tumour stage correlated to lower KIT expression in ccRCC. Simultaneous expression of SCF and KIT in renal tumours, which seems to undergo a shift from the cytoplasm to the cell membrane, suggests paracrine and autocrine mechanisms in KIT activation, with different, as yet unknown, regulatory mechanisms in the different tumour entities.
    Keywords: Carcinoma, Renal Cell -- Pathology ; Kidney Neoplasms -- Pathology ; Proto-Oncogene Proteins C-Kit -- Metabolism ; Stem Cell Factor -- Metabolism
    E-ISSN: 1791-7530
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Urologia Internationalis, May 2010, Vol.84(4), pp.388-394
    Description: Objectives: Endorectal coil magnetic resonance imaging (EC-MRI) is useful to evaluate prostate cancer localization. Herein, we evaluate sensitivity and specificity of EC-MRI in different regions of the prostate by comparing the acquired images to whole-mount sections of the prostate after radical prostatectomy. Methods: 69 patients with localized prostate cancer were included. After virtually dividing the prostate into 12 sectors, results of EC-MRI were compared to corresponding whole-mount sections by contingency analysis. Sensitivity and specificity were calculated for each of the 12 areas as well as for the dorsal and ventral region. Results: Sensitivity right/left was dorsal apex/mid/base 41/41, 60/67 and 73/79%; ventral 33/52, 43/42 and 47/52%. Specificity right/left was dorsal apex/mid/base 92/89, 82/75 and 88/69%; ventral 100/100, 100/92 and 88/83%. Local sensitivity and specificity regarding dorsal versus ventral was 88/100 and 65/87%. Conclusions: Local sensitivity decreased from basodorsal to apicoventral direction, whereas local specificity increased in the same direction. Therefore, prostate cancers demonstrated by MRI are more prone to be detected in the basodorsal region, whereas less false-positive results are found in the apicoventral region. These variations in topographical specificity and sensitivity need to be considered before radical prostatectomy or MRI-guided biopsy.
    Keywords: Original Paper ; Endorectal Coil ; Local Staging ; Magnetic Resonance Imaging ; Radical Prostatectomy ; Endorectal Coil Magnetic Resonance Imaging, Sensitivity and Specificity ; Medicine
    ISSN: 0042-1138
    E-ISSN: 1423-0399
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages