Tetrahedron Letters, 26 October 2016, Vol.57(43), pp.4863-4865
A new 16-membered diene macrolide, bafilomycin M ( ), was produced from a sp. GIC10-1, which was originally isolated from a marine sponge sp. The structure of was established by spectroscopic methods and this compound was found to exhibit cytotoxicity toward K-562, HL-60, SUPT-1, and LNCaP tumor cells with IC values 0.060, 0.011, 0.047, and 0.389 μg/mL, respectively.
Bafilomycin ; Streptomyces ; Theonella ; Cytotoxicity ; Chemistry
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