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  • Wen, Zhi-Hong  (60)
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  • 1
    Language: English
    In: Tetrahedron, 25 November 2012, Vol.68(47), pp.9694-9700
    Description: Nine new steroids, sclerosteroids A–I ( , , , – ), along with 18 known metabolites ( – , , – ), were isolated from the soft coral These structures were elucidated on the basis of detailed spectroscopic analysis. The absolute configurations of sugar moieties in steroidal glycosides – were determined by HPLC analysis of the -tolylthiocarbamate derivatives of the liberated sugars from hydrolysis of these steroidal giycosides. Cytotoxic and anti-inflammatory activities of these compounds were measured in vitro.
    Keywords: Scleronephthya Gracillimum ; Sclerosteroids ; O-Tolylthiocarbamate ; Cytotoxic Activity ; Anti-Inflammatory Activity ; Chemistry
    ISSN: 0040-4020
    E-ISSN: 1464-5416
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  • 2
    Language: English
    In: Bioorganic & Medicinal Chemistry Letters, 01 July 2016, Vol.26(13), pp.3060-3063
    Description: Chemical investigation on the EtOAc-soluble fraction from the MeOH/DCM extract of a gorgonian sp. afforded two new sterols, 11-acetoxy-24 -methyl-3 ,5 ,6 -trihydroxy-9,11-secocholest-7-en-9-one ( ) and 5 ,6 -epoxy-(22 ,24 )-ergosta-8,22-diene-3 ,7 -diol ( ). The structures of sterols and were elucidated on the basis of spectroscopic analysis and by comparison of their spectroscopic data with those of related analogues. Both and were shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.
    Keywords: Pinnigorgia ; Gorgonian ; Sterol ; Anti-Inflammatory Activity ; Inos ; Cox-2 ; Medicine ; Chemistry ; Anatomy & Physiology
    ISSN: 0960-894X
    E-ISSN: 1464-3405
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  • 3
    Language: English
    In: Tetrahedron, 18 February 2016, Vol.72(7), pp.944-951
    Description: Eight new briarane diterpenoids, designated briarenolides M–T ( – ), were isolated from an octocoral identified as sp. The structures of briaranes – were established by spectroscopic methods and by comparison of the spectroscopic data with those of known analogues. The relationship between H and C NMR chemical shifts of 2-hydroxybriaranes possessing of (A) a Δ -conjugated diene moiety or (B) a Δ -conjugated diene moiety are described. Briarenolides M ( ), P ( ), S ( ), and T ( ) were found to inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase (iNOS) protein and briarenolides N ( ), P ( ), and T ( ) were found to inhibit the accumulation of the pro-inflammatory cyclooxygenase-2 (COX-2) protein in LPS (lipopolysaccharide)-stimulated RAW264.7 macrophage cells.
    Keywords: Briarane ; Briarenolide ; Briareum ; Anti-Inflammatory ; Inos ; Cox-2 ; Chemistry
    ISSN: 0040-4020
    E-ISSN: 1464-5416
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  • 4
    Language: English
    In: Tetrahedron Letters, 14 September 2016, Vol.57(37), pp.4239-4242
    Description: Two new eunicellin-type diterpenoids, cladieunicellins R ( ) and S ( ), were isolated from the octocoral and their structures were elucidated by spectroscopic methods. Eunicellin was proven to be the first 2,6-hemiketal eunicellin and was found to exhibit moderate cytotoxicity toward the MOLT-4, K562, and SUP-T1 cells.
    Keywords: Cladiella Tuberculosa ; Eunicellin ; Cladieunicellin ; Cytotoxicity ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 5
    Language: English
    In: Tetrahedron Letters, 29 October 2014, Vol.55(44), pp.6065-6067
    Description: A novel 6,12-dichlorobriarane diterpenoid, briarenolide J ( ), was isolated from an octocoral identified as sp. The structure of briarane was elucidated by spectroscopic methods. Briarenolide J ( ) is the first metabolite of a briarane-related natural product found to possess a chlorine atom at C-12 and this compound was found to display inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils with IC values of 14.98 and 9.96 μM, respectively.
    Keywords: Briareum ; Octocoral ; Briarane ; Briarenolide ; Diterpenoid ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 6
    In: Organic & Biomolecular Chemistry, 2011, Vol.9(9), pp.3272-3278
    Description: Seven new polyoxygenated steroids, hirsutosterols A–G ( 1–7 ), were isolated from the Formosan soft coral Cladiella hirsuta . Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configurations of 1 and 5 were determined by Mosher's method. Sterols 4–6 possess hydroxy groups at C-9 and C-11 and might be oxidatively cleaved to the corresponding 9,11-secosterols. Hirsutosterol A ( 1 ) was found to exhibit a stronger cytotoxicity against a limited panel of cancer cell lines.
    Keywords: Anthozoa -- Chemistry ; Oxygen -- Chemistry ; Steroids -- Chemistry;
    ISSN: 1477-0520
    E-ISSN: 1477-0539
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  • 7
    Language: English
    In: Marine Drugs, 01 January 2013, Vol.11(1), pp.136-145
    Description: Three new steroidal carboxylic acids, paraminabic acids A–C (1–3) were isolated from a Formosan soft coral Paraminabea acronocephala. The structures of these compounds were established by extensive spectroscopic analysis and chemical methods. Application of the PGME method allowed the establishment of the absolute configurations at C-25 and C-24 for 1 and 2, respectively. Compound 3 showed potent cytotoxicity toward Hep3B, MDA-MB-231, MCF-7, and A-549 cancer cell lines, with IC50 values ranging from 2.05 to 2.83 μg/mL. Compounds 2 and 3 were found to inhibit the accumulation of the pro-inflammatory iNOS protein.
    Keywords: Paraminabea Acronocephala ; Paraminabic Acid ; Soft Coral ; Cytotoxicity ; Anti-Inflammatory Activity ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1660-3397
    E-ISSN: 1660-3397
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  • 8
    Language: English
    In: ChemInform, September 2016, Vol.47(42), pp.no-no
    Description: Two new sterols (I) and (II) are isolated from a gorgonian Pinnigorgia sp.
    Keywords: Steroids ; Antiinflammatory Activity ; Structure Organic Substances
    ISSN: 0931-7597
    E-ISSN: 1522-2667
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  • 9
    In: Organic & Biomolecular Chemistry, 2011, Vol.9(3), pp.834-844
    Description: New eunicellin-base diterpenoids, klysimplexins I–T ( 1–12 ), were isolated from a cultured soft coral Klyxum simplex . Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute stereochemistry of 4 was determined by Mosher's method. Compounds 9 and 12 have been shown to exhibit cytotoxicity toward a limited panel of cancer cell lines. Compounds 2–6 , 10 and 11 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. Compounds 10 and 11 also could effectively reduce the level of COX-2 protein.
    Keywords: Chemistry;
    ISSN: 1477-0520
    E-ISSN: 1477-0539
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  • 10
    Language: English
    In: Marine Drugs, 01 February 2017, Vol.15(2), p.44
    Description: The structures, names, bioactivities, and references of 124 briarane-type natural products, including 66 new metabolites, isolated between 2014 and 2016 are summarized in this review article. All of the briarane diterpenoids mentioned in this review were isolated from octocorals, mainly from Briareum violacea, Dichotella gemmacea, Ellisella dollfusi, Junceella fragilis, Junceella gemmacea, and Pennatula aculeata. Some of these compounds exhibited potential biomedical activities, including anti-inflammatory activity, antibacterial activity, and cytotoxicity towards cancer cells.
    Keywords: Briarane ; Octocoral ; Briareum ; Dichotella ; Ellisella ; Junceella ; Pennatula ; Pharmacy, Therapeutics, & Pharmacology
    E-ISSN: 1660-3397
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