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  • Wiese, Birgitt  (113)
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  • 1
    In: European Journal of Haematology, December 2006, Vol.77(6), pp.463-470
    Description: : Friend leukemia integration‐1 (Fli‐1), a member of the Ets gene family of transcription factors, has been demonstrated to be a target of a leukaemia inducing virus in mice, and is known to be part of a fusion gene in Ewings’ sarcoma in humans. Wild‐type Fli‐1 is involved in lineage commitment of megakaryocytes and myeloid progenitors through induction of Janus kinases (JAKs) following ligand binding to cytokine and growth factor receptors. Proliferation of atypical megakaryocytes is a predominant histopathological feature in Philadelphia chromosome negative chronic myeloproliferative disorders (Ph CMPD) and a potential aberrant expression of Fli‐1 has not been investigated so far. : Fli‐1 expression was investigated by real‐time RT‐PCR and immunohistochemistry in bone marrow cells derived from Ph CMPD ( = 80) and non‐neoplastic haematopoiesis ( = 21) following determination of the JAK2 status. : Fli‐1 mRNA expression was significantly higher in Essential thrombocythaemia (ET) with JAK2 (V617F) compared with other Ph CMPD and control ( 〈 0.001). By immunohistochemistry, Fli‐1 protein could be detected in nuclei of atypical megakaryocytes in Ph CMPD and, less accentuated, in non‐neoplastic megakaryocytes. Fli‐1 protein expression by myeloid progenitors was considerably heterogenous in Ph CMPD independent of an underlying JAK2 (V617F) mutation and without notable differences to non‐neoplastic haematopoiesis. : Fli‐1 is rather constitutively expressed by bone marrow cells in Ph CMPD independent of the underlying JAK2 status. The overall stronger labelling for Fli‐1 in megakaryocytes in Ph CMPD most likely reflects the degree of polyploidisation but aberrant activation of nuclear target genes can not be excluded.
    Keywords: Chronic Myeloproliferative Disorders ; Janus Kinase 2 V617f Mutation ; Fli‐1 Expression ; Real‐Time Rt‐Pcr ; Immunohistochemistry
    ISSN: 0902-4441
    E-ISSN: 1600-0609
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  • 2
    Language: English
    In: Psychology and Aging, 2012, Vol.27(2), pp.353-363
    Description: Midlife motivational abilities, that is, skills to initiate and persevere in the implementation of goals, have been related to mental and physical health, but their association with risk of mild cognitive impairment (MCI) and Alzheimer's disease (AD) has not yet been directly investigated. This relation was examined with data from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). A total of 3,327 nondemented participants (50.3% of a randomly selected sample) aged 75–89 years were recruited in primary care and followed up twice (after 1.5 and 3 years). Motivation-related occupational abilities were estimated on the basis of the main occupation (assessed at follow-up II) using the Occupational Information Network (O* NET) database, which provides detailed information on worker characteristics and abilities. Cox proportional hazards models were used to evaluate the relative risk of developing MCI and AD in relation to motivation-related occupational abilities, adjusting for various covariates. Over the 3 years of follow-up, 15.2% participants developed MCI and 3.0% developed AD. In a fully adjusted model, motivation-related occupational abilities were found to be associated with a reduced risk of MCI (HR: 0.77; 95% CI: 0.64–0.92). Motivation-related occupational abilities were associated with reduced risk of AD in ApoE ε4 carriers (HR: 0.48; CI: 0.25–0.91), but not in noncarriers (HR: 0.99; CI: 0.65–1.53). These results suggest that midlife motivational abilities are associated with reduced risk of MCI in general and with reduced risk of AD in ApoE ε4 carriers. Revealing the mechanisms underlying this association may inform novel prevention strategies for decelerating cognitive decline in old age.
    Keywords: Motivation ; Self-Regulation ; Alzheimer'S Disease ; Dementia ; Mild Cognitive Impairment
    ISSN: 0882-7974
    E-ISSN: 1939-1498
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  • 3
    In: Age and Ageing, 2013, Vol. 42(2), pp.173-180
    Description: Objective: to determine incidence and predictors of late-life depression. this is a 3-year observational cohort study of 3,214 non-demented patients aged 75 and over completing three waves of assessment. The patients were recruited in 138 primary care practices in six urban areas in Germany. Depressive symptoms were measured at baseline, and 18 months and 36 months later using the GDS-15 Geriatric Depression Scale with a cut-off 0–5/6–15. Cox proportional hazard regression models were applied to examine predictors of incident depression, adjusting for sex, age, education, living situation, activities of daily living - and instrumental activities of daily living impairment, somatic comorbidity, alcohol consumption, smoking, mild cognitive impairment and apoE4 status. the incidence of depression was 36.8 (95% CI: 29.6–45.3) per 1,000 person-years in men and 46.0 (95% CI: 39.9–52.8) in women (sex difference = 0.069). The incidence increased from 35.4 (95% CI: 29.7–41.9) per 1000 person-years between the ages of 75 and 79 to 75.2 (95% CI: 53.2–103.2) for subjects 85 years and older. After full adjustment for confounding variables, hazard ratios (HR) for incident depression were significantly higher for subjects 85 years and older (HR: 1.83, 95% CI: 1.24–2.70) and those with mobility impairment (HR: 2.53, 95% CI: 1.97–3.25), vision impairment (HR: 1.41, 95% CI: 1.04–1.91), mild cognitive impairment (HR: 1.52, 95% CI: 1.10–2.10), subjective memory impairment (HR: 1.33, 95% CI: 1.01–1.74) and current smoking (HR: 1.69, 95% CI: 1.13–2.53). the incidence of depression increased significantly with age. In designing prevention programmes, it is important to call more attention on functional impairment, cognitive impairment and smoking.
    Keywords: Incident Depression ; Predictors ; Prospective Longitudinal Study ; Older People
    ISSN: 0002-0729
    E-ISSN: 1468-2834
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  • 4
    Language: English
    In: European archives of psychiatry and clinical neuroscience, November 2010, Vol.260 Suppl 2, pp.S111-5
    Description: An increasing number of longitudinal cohort studies have identified a risk increase for dementia by the chronic use of drugs with anticholinergic properties. The respective data from the German Study on Aging, Cognition and Dementia in Primary Care Patients (AgeCoDe) also showing risk increase (hazard ratio = 2.081) are reported here. The mechanisms by which the risk increase is transported are still unknown. Irritation of compensated alterations of cholinergic transmission at the pre-dementia stage of Alzheimer's disease (AD) or acceleration of neuroinflammation by disturbance of the anti-inflammatory effect of cholinergic innervation are discussed. In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition.
    Keywords: Dementia ; Cholinergic Antagonists -- Adverse Effects
    ISSN: 09401334
    E-ISSN: 1433-8491
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  • 5
    Language: English
    In: Journal of General Internal Medicine, 2009, Vol.24(12), pp.1314-1317
    Description: Byline: Michael Pentzek (1), Angela Fuchs (1), Birgitt Wiese (2), Gabriela Cvetanovska-Pllashniku (3), Franziska Haller (3), Wolfgang Maier (3), Steffi G. Riedel-Heller (4), Matthias C. Angermeyer (5), Horst Bickel (6), Edelgard Mosch (6), Siegfried Weyerer (7), Jochen Werle (7), Hendrik Bussche (8), Marion Eisele (8), Hanna Kaduszkiewicz (8) Keywords: general practice; cognition; dementia; clinical judgment Abstract: Background General practitioners (GP) play an important role in detecting cognitive impairment among their patients. Objectives To explore factors associated with GPs' judgment of their elderly patients' cognitive status. Design Cross-sectional data from an observational cohort study (AgeCoDe study) General practice surgeries in six German metropolitan study centers home visits by interviewers. Participants 138 GPs, 3,181 patients (80.13+-3.61 years, 65.23% female). Measurements General practitioner questionnaire for each patient: familiarity with the patient, patient morbidity, judgment of cognitive status. Home visits by trained interviewers: sociodemographic and clinical data, psychometric test performance. Multivariate regression analysis was used to identify independent associations with the GPs' judgment of "cognitively impaired" vs. "cognitively unimpaired." Results Less familiar patients (adjusted odds ratio [aOR] 2.42, 95% CI 1.35--4.32, for poor vs. very high familiarity), less mobile patients (aOR 1.29, 95% CI 1.13--1.46), patients with impaired hearing (aOR 5.46, 95% CI 2.35--12.67 for serious vs. no problems), and patients with greater comorbidity (aOR 1.15, 95% CI 1.08--1.22) were more likely to be rated as "cognitively impaired" by their GPs. Conclusions The associations between GPs' assessments of cognitive impairment and their familiarity with their patients and patients' mobility, hearing, and morbidity provide important insights into how GPs make their judgments. Author Affiliation: (1) Department of General Practice, University Medical Center Dusseldorf, Moorenstrasse 5, 40225, Dusseldorf, Germany (2) Center of Biometrics and Medical Informatics, Hannover Medical School, 30625, Hannover, Germany (3) Department of Psychiatry, University of Bonn, 53105, Bonn, Germany (4) Public Health Research Unit, Department of Psychiatry, University of Leipzig, 04317, Leipzig, Germany (5) Center for Public Mental Health, 3482, Gosing am Wagram, Austria (6) Clinic and Polyclinic for Psychiatry and Psychotherapy, Munich Technical University, 81675, Munich, Germany (7) Central Institute of Mental Health, 68159, Mannheim, Germany (8) Department for Primary Medical Care, Center of Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany Article History: Registration Date: 02/09/2009 Received Date: 12/01/2009 Accepted Date: 02/09/2009 Online Date: 21/10/2009 Article note: Further members of the AgeCoDe Study Group: Heinz-Harald Abholz, Cadja Bachmann, Michaela Buchwald, Mirjam Colditz, Moritz Daerr, Sandra Eifflander-Gorfer, Sven Heinrich, Frank Jessen, Teresa Kaufeler, Hans-Helmut Konig, Tobias Luck, Melanie Luppa, Manfred Mayer, Julia Olbrich, Heinz-Peter Romberg, Anja Rudolph, Melanie Sauder, Britta Schuermann, Michael Wagner, Anja Wollny, and Thomas Zimmermann.
    Keywords: general practice ; cognition ; dementia ; clinical judgment
    ISSN: 0884-8734
    E-ISSN: 1525-1497
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  • 6
    Language: English
    In: Health and Quality of Life Outcomes, 01 July 2017, Vol.15(1), pp.1-8
    Description: Abstract Background Thus far, only a few longitudinal studies investigated the impact of social engagement on health-related quality of life (HRQoL) and depressive symptoms in old age. Therefore, we aimed to examine the impact of social engagement on HRQoL and depressive symptoms in late life....
    Keywords: Depressive Symptoms ; Eq-Vas ; Geriatric Depression Scale ; Health-Related Quality of Life ; Old Age ; Public Health
    E-ISSN: 1477-7525
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  • 7
    In: Journal of the American Geriatrics Society, January 2012, Vol.60(1), pp.130-135
    Description: OBJECTIVESTo compare the accuracy of commonly used tasks with that of the Visual Association Test (VAT), a conceptually different test involving cued recall of pictorial stimuli, in the recognition of dementia within primary care. DESIGNA cross-sectional diagnostic study of concurrent validity. SETTINGTwenty-nine German primary care practices. PARTICIPANTSFour hundred twenty-three individuals in primary care participating in a longitudinal cohort study. MEASUREMENTSParticipants underwent a comprehensive neuropsychological interview. The validated clinical dementia diagnosis was used as reference standard. Index tests comprised the VAT, Mini-Cog, clock drawing, verbal fluency, episodic memory, and subjective complaints. Validity parameters were calculated; possible confounders of test performance (age, sex, education, comorbidity, depression, language) were evaluated. RESULTSTwenty-one participants (5%) had dementia according to the reference standard. The VAT distinguished dementia from nondementia with a sensitivity of 95.2% (95% confidence interval (CI) = 86.1-100.0), a specificity of 96.0% (95% CI = 94.1-97.9), a positive predictive value (PPV) of 55.6% (95% CI = 39.3-71.8), and a negative predictive value (NPV) of 99.7% (95% CI = 99.2-100.0). The next-most-accurate tasks were the Mini-Cog and immediate and delayed recall. Their sensitivity and NPV are similar to those of the VAT, but their PPV and specificity were significantly lower than those of the VAT. Age and depression affected all test scores. CONCLUSIONThe VAT (cued recall of pictorial material) is superior to other tasks for the recognition of dementia in terms of higher specificity and PPV. Age-specific cutoff scores may improve the validity of all tests.
    Keywords: Dementia ; Primary Care ; Cued Recall ; Memory ; Sensitivity ; Specificity
    ISSN: 0002-8614
    E-ISSN: 1532-5415
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  • 8
    In: Age and Ageing, 2011, Vol. 40(4), pp.456-463
    Description: Objective: to investigate prospectively the relationship between current alcohol consumption (quantity and type of alcohol) and incident overall dementia and Alzheimer dementia. the study is based on individuals (75+) attending general practitioners in Germany: 3,202 subjects free of dementia were studied at baseline, 1.5 years and 3 years later by means of structured clinical interviews including detailed assessment of current alcohol consumption and DSM-IV dementia diagnoses. Associations between alcohol consumption (in grams of ethanol), type of alcohol (wine, beer, mixed alcohol beverages) and incident dementia were examined using Cox proportional hazard models, controlling for several confounders. incident overall dementia occurred in 217 of 3,202 participants over a mean follow-up period of 3 years. Significant relationships were found between alcohol consumption (prevalence at baseline: 50.0%) and incident overall dementia (adjusted hazard ratio (HR) 0.71, 95% CI 0.53–0.96), respectively, incident Alzheimer dementia (adjusted HR 0.58, 95% CI 0.38–0.89). With regard to quantity of alcohol and type of alcohol, all hazard ratios were found to be lower than 1. in agreement with meta-analyses that include younger age groups, our study suggests that light-to-moderate alcohol consumption is inversely related to incident dementia, also among individuals aged 75 years and older.
    Keywords: Incident Dementia ; Alcohol Consumption ; Prospective Longitudinal Study ; Elderly
    ISSN: 0002-0729
    E-ISSN: 1468-2834
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  • 9
    Language: English
    In: Social psychiatry and psychiatric epidemiology, February 2012, Vol.47(2), pp.263-70
    Description: In the last decades, many community-based studies have addressed predictors of nursing home placement (NHP) among the elderly. So far, predictors have not been analyzed separately for different age groups. For a German GP-sample of 3,208 subjects aged 75 years and older, socio-demographic, clinical, and psychometric parameters were requested every 1.5 years over three waves. Logistic regression models determined predictors of NHP for total sample and for two different age groups. A CART analysis identified factors discriminating best between institutionalized and non-institutionalized individuals. Of the overall sample, 4.7% of the sample (n = 150) was institutionalized during the study period. Baseline characteristics associated with a higher risk of NHP for the total sample were age, living without spouse, cognitive and functional impairment and depression. In the CART analysis, age was the major discriminator at the first level (at age 81). In subgroup regression analyses, for the younger elderly (age 75-81) being single as well as cognitive and functional impairment increased the risk of NHP; in the advanced elderly (age 82+) being widowed and subjective memory impairment were significant predictors for NHP, and cognitive and functional impairment became non-significant as predictors of NHP. Predictors of NHP may differ in old age groups. The fact that many predictors show inconsistent results as predictors of NHP in the international literature may be attributed to the lack of differentiation in age groups.
    Keywords: Aging -- Psychology ; Cognition Disorders -- Epidemiology ; Dementia -- Epidemiology ; Institutionalization -- Trends
    ISSN: 09337954
    E-ISSN: 1433-9285
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  • 10
    In: Journal of the American Geriatrics Society, November 2015, Vol.63(11), pp.2408-2410
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/jgs.13802/abstract Byline: Claudia Luck-Sikorski, Melanie Luppa, Kathrin Heser, Markus Bleckwenn, Tina Posselt, Annette Ernst, Jochen Werle, Dagmar Weeg, Edelgard Mosch, Birgitt Wiese, Susanne Steinmann, Angela Fuchs, Michael Pentzek, Hans-Helmut Konig, Christian Brettschneider, Martin Scherer, Wolfgang Maier, Siegfried Weyerer, Steffi G. Riedel-Heller ***** No abstract is available for this article. ***** Article Note: Shared last authorship
    Keywords: Heart Failure – Prognosis ; Heart Failure – Psychological Aspects ; Heart Failure – Health Aspects ; Elderly – Psychological Aspects ; Elderly – Health Aspects ; Mortality – Psychological Aspects ; Depression (Mood Disorder) – Prognosis ; Depression (Mood Disorder) – Psychological Aspects ; Depression (Mood Disorder) – Health Aspects;
    ISSN: 0002-8614
    E-ISSN: 1532-5415
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