Food Chemistry, 01 September 2013, Vol.140(1-2), pp.305-314
roots showed oestrogenic and anti-platelet activities. ► Twenty-six compounds were isolated and divided into 10 different skeletons. ► The biosynthetic pathway of the isolated dihydrobenzofuroisocoumarins was proposed. can be used to develop nutritional dietary supplements. The ethanolic extract of (Liliaceae) roots showed potential oestrogenic and anti-platelet activities. Twenty-six compounds were isolated and classified as 10 skeletons, including two unusual new dihydrobenzofuroisocoumarins, (+)-platyphyllarin A ( ) and B ( ), one new butanoate, ethyltributanoate ( ), and two new homoisoflavanones, (−)-liriopein A ( ) and B ( ), along with 21 known compounds, including six homoisoflavonoids, one chalcone, six amides, one lignan, one fatty acid derivative, one alkaloid, three benzenoids, and two steroids. The biosynthetic pathway of compounds and was proposed in the current investigation. The oestrogenic activity of the isolates was evaluated utilising the pER8:GUS reporter assay system in transgenic plant as well as the SEAP reporter assay system in MCF-7 breast cancer cell-line; the anti-platelet activity was evaluated using the anti-platelet aggregation assay. Several components exhibited significant oestrogenic and anti-platelet activities; demonstrating for the first time the potential use of as a nutritional supplement for cardiovascular and endocrine diseases.
Liriope Platyphylla ; Dihydrobenzofuroisocoumarin ; Homoisoflavonoid ; Oestrogenic Activity ; Anti-Platelet Effect ; Arabidopsis Per8:Gus Reporter Assay ; Chemistry ; Diet & Clinical Nutrition ; Economics
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