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  • Directory of Open Access Journals (DOAJ)  (93)
Type of Medium
Language
Year
  • 1
    Language: English
    In: PLoS ONE, 2011, Vol.6(5), p.e20506
    Description: There are at least 250 enzymes in Mycobacterium tuberculosis ( M. tuberculosis ) involved in lipid metabolism. Some of the enzymes are required for bacterial survival and full virulence. The esterase Rv0045c shares little amino acid sequence similarity with other members of the esterase/lipase family. Here, we report the 3D structure of Rv0045c. Our studies demonstrated that Rv0045c is a novel member of α/β hydrolase fold family. The structure of esterase Rv0045c contains two distinct domains: the α/β fold domain and the cap domain. The active site of esterase Rv0045c is highly conserved and comprised of two residues: Ser154 and His309. We proposed that Rv0045c probably employs two kinds of enzymatic mechanisms when hydrolyzing C-O ester bonds within substrates. The structure provides insight into the hydrolysis mechanism of the C-O ester bond, and will be helpful in understanding the ester/lipid metabolism in M. tuberculosis .
    Keywords: Research Article ; Biology ; Medicine ; Infectious Diseases ; Biophysics ; Biochemistry
    E-ISSN: 1932-6203
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  • 2
    In: Discrete Dynamics in Nature and Society, 2018, Vol.2018, 8 pages
    Description: This paper describes the peak, fat tail, and skewness characteristics of asset price via a Lévy process. It applies asymmetric GARCH model to depict asset price’s random volatility characteristics and builds a GARCH-Lévy option pricing model with random jump characteristics. It also uses circular maximum likelihood estimation technology to improve the stability of model parameter estimation. In order to test the model’s pricing results, we use Hong Kong Hang Seng Index (HSI) price data and its option data to carry out empirical studies. Results prove that the pricing bias of EGARCH-Lévy model is lower than that of standard Heston-Nandi (HN) model in the financial industry. For short-term, middle-term, and long-term European-style options, the pricing error of EGARCH-Lévy model is the lowest.
    Keywords: Engineering;
    ISSN: 1026-0226
    E-ISSN: 1607-887X
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  • 3
    Language: English
    In: Diagnostic Pathology, 01 June 2012, Vol.7(1), p.77
    Description: Abstract Paragangliomas are rare neoplasms arising from undifferentiated cells of the primitive neural crest. We report a case of a 57-year-old patient with renal pigmented paraganglioma that was an incidental finding. Histopathological examination...
    Keywords: Pigmented Paraganglioma ; Kidney ; Differential Diagnosis
    ISSN: 1746-1596
    E-ISSN: 1746-1596
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  • 4
    Language: English
    In: Shock and Vibration, 01 January 2018, Vol.2018
    Description: In soft soil areas, such as the Nanjing, it is very important to quantitatively analyze the dynamic behaviors of soft soils during the metro train operation. A nonlinear coupling model of wheel-track and a finite element calculation model of tunnel and soil were established based on the mechanical...
    Keywords: Engineering ; Physics
    ISSN: 1070-9622
    E-ISSN: 1875-9203
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  • 5
    Language: English
    In: Journal of Big Data, 2017, Vol.4(1), pp.1-25
    Description: Outliers are samples that are generated by different mechanisms from other normal data samples. Graphs, in particular social network graphs, may contain nodes and edges that are made by scammers, malicious programs or mistakenly by normal users. Detecting outlier nodes and edges is important for data mining and graph analytics. However, previous research in the field has merely focused on detecting outlier nodes. In this article, we study the properties of edges and propose effective outlier edge detection algorithm. The proposed algorithms are inspired by community structures that are very common in social networks. We found that the graph structure around an edge holds critical information for determining the authenticity of the edge. We evaluated the proposed algorithms by injecting outlier edges into some real-world graph data. Experiment results show that the proposed algorithms can effectively detect outlier edges. In particular, the algorithm based on the Preferential Attachment Random Graph Generation model consistently gives good performance regardless of the test graph data. More important, by analyzing the authenticity of the edges in a graph, we are able to reveal underlying structure and properties of a graph. Thus, the proposed algorithms are not limited in the area of outlier edge detection. We demonstrate three different applications that benefit from the proposed algorithms: (1) a preprocessing tool that improves the performance of graph clustering algorithms; (2) an outlier node detection algorithm; and (3) a novel noisy data clustering algorithm. These applications show the great potential of the proposed outlier edge detection techniques. They also address the importance of analyzing the edges in graph mining—a topic that has been mostly neglected by researchers.
    Keywords: Outlier detection ; Graph mining ; Outlier edge
    E-ISSN: 2196-1115
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  • 6
    Language: English
    In: PLoS ONE, 01 January 2014, Vol.9(11), p.e110773
    Description: Brain derived neurotrophic factor (BDNF) has been known to play an important role in various mental disorders or diseases such as Alzheimer's disease (AD). The aim of our study was to assess whether BDNF promoter methylation in peripheral blood was able to predict the risk of AD. A total of...
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: Scientific Reports, 01 August 2018, Vol.8(1), pp.1-6
    Description: Abstract This clinical retrospective study explored factors associated with distal tibiofibular syndesmosis ossification (TFSO) after ankle fracture fixation. Between August 2012 and January 2015, 172 patients with ankle fractures (121 men)...
    Keywords: Biology
    E-ISSN: 2045-2322
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  • 8
    Language: English
    In: Sustainability, 01 January 2018, Vol.10(1), p.221
    Description: The spatial behavior of tourists is an important part of the research on congestion management and sustainable planning of tourism destinations. Combined with user-generated content (UGC) and site-based survey data, this study conducted an overlaying analysis between street network configurations...
    Keywords: Space Syntax ; Spatial Configuration ; Online Attention ; Tourist Flow ; Mountain Tourism ; China ; Environmental Sciences ; Economics
    E-ISSN: 2071-1050
    Source: Directory of Open Access Journals (DOAJ)
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  • 9
    Language: English
    In: Virology Journal, 01 January 2013, Vol.10(1), p.26
    Description: Abstract Background Porcine epidemic diarrhea virus (PEDV) is an important pathogen in swine and is responsible for substantial economic losses. Previous studies suggest that the PEDV E protein plays an important role in the viral assembly process. However, the subcellular localization and...
    Keywords: Pedv ; E Protein ; Er Stress ; Il-8 ; Nf-Κb ; Bcl-2 ; Medicine ; Biology
    ISSN: 1743-422X
    E-ISSN: 1743-422X
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  • 10
    Language: English
    In: Frontiers in Psychology, Sept 25, 2018
    Keywords: Deep Learning ; Dynamic Features ; Facial Recognition ; Lip Corners ; Smiles;
    ISSN: 1664-1078
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