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  • Elsevier (CrossRef)  (121)
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  • 1
    Language: English
    In: Current Opinion in Microbiology, April 2013, Vol.16(2), pp.109-111
    Keywords: Bacteria–Genetics ; Bacterial Physiological Phenomena–Genetics ; Gene Expression Regulation, Bacterial–Genetics ; Signal Transduction–Genetics ; Stress, Physiological–Genetics;
    ISSN: 1369-5274
    E-ISSN: 18790364
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  • 2
    Language: English
    In: Cell, 11 April 2013, Vol.153(2), pp.426-437
    Description: Glucose homeostasis is strictly controlled in all domains of life. Bacteria that are unable to balance intracellular sugar levels and deal with potentially toxic phosphosugars cease growth and risk being outcompeted. Here, we identify the conserved haloacid dehalogenase (HAD)-like enzyme YigL as the previously hypothesized phosphatase for detoxification of phosphosugars and reveal that its synthesis is activated by an Hfq-dependent small RNA in Salmonella typhimurium. We show that the glucose-6-P-responsive small RNA SgrS activates YigL synthesis in a translation-independent fashion by the selective stabilization of a decay intermediate of the dicistronic pldB-yigL messenger RNA (mRNA). Intriguingly, the major endoribonuclease RNase E, previously known to function together with small RNAs to degrade mRNA targets, is also essential for this process of mRNA activation. The exploitation of and targeted interference with regular RNA turnover described here may constitute a general route for small RNAs to rapidly activate both coding and noncoding genes. Graphical Abstract Highlights► The bacterial small RNA SgrS posttranscriptionally activates the synthesis of YigL ► YigL is the previously hypothesized phosphatase that prevents phosphosugar toxicity ► SgrS activates yigL by a translation-independent mRNA-stabilization mechanism ► SgrS stabilizes an intermediate in the yigL mRNA decay pathway YigL, a long-sought bacterial phosphatase, regulates glucose-6-phosphate levels. A small regulatory RNA upregulates YigL synthesis by base pairing with the coding sequence of the preceding gene to interfere with endonucleolytic yigL mRNA decay.
    Keywords: Ribonuclease ; Glucose Metabolism ; Homeostasis ; Phosphatases ; Bacteria ; Messenger Rna ; Glucose;
    ISSN: 0092-8674
    E-ISSN: 10974172
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  • 3
    Language: English
    In: Molecular Cell, 7 May 2015, Vol.58(3), pp.389-390
    Description: Natural RNA sponges sequestering cellular noncoding RNA molecules have been found in diverse organisms. In this issue, Lalaouna et al. (2015) report another type of RNA sponge, showing that stable intermediates of bacterial tRNA processing control endogenous small RNAs. Natural RNA sponges sequestering cellular noncoding RNA molecules have been found in diverse organisms. In this issue, Lalaouna et al. (2015) report another type of RNA sponge, showing that stable intermediates of bacterial tRNA processing control endogenous small RNAs.
    Keywords: Transfer RNA ; Antisense RNA;
    ISSN: 1097-2765
    E-ISSN: 10974164
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  • 4
    Language: English
    In: Molecular Cell, 4 February 2016, Vol.61(3), pp.352-363
    Description: Small RNAs (sRNAs) from conserved noncoding genes are crucial regulators in bacterial signaling pathways but have remained elusive in the Cpx response to inner membrane stress. Here we report that an alternative biogenesis pathway releasing the conserved mRNA 3′ UTR of stress chaperone CpxP as an ∼60-nt sRNA provides the noncoding arm of the Cpx response. This so-called CpxQ sRNA, generated by general mRNA decay through RNase E, acts as an Hfq-dependent repressor of multiple mRNAs encoding extracytoplasmic proteins. Both CpxQ and the Cpx pathway are required for cell survival under conditions of dissipation of membrane potential. Our discovery of CpxQ illustrates how the conversion of a transcribed 3′ UTR into an sRNA doubles the output of a single mRNA to produce two factors with spatially segregated functions during inner membrane stress: a chaperone that targets problematic proteins in the periplasm and a regulatory RNA that dampens their synthesis in the cytosol. •RNase E cleaves the 3′ end of cpxP mRNA to release a small RNA, CpxQ•CpxQ together with the Hfq protein represses mRNAs of envelope proteins•CpxQ and the Cpx pathway protect bacteria against inner membrane damage•Cytosolic activity of CpxQ sRNA complements periplasmic function of CpxP protein Chao and Vogel discover that a small RNA cleaved off the 3′ end of an mRNA provides the elusive regulatory noncoding arm of the bacterial Cpx response to inner membrane stress.
    Keywords: Cpx Pathway ; Cpxp ; Cpxq ; 3′ Utr ; Hfq ; Rnase E ; Noncoding RNA ; Nhab ; Envelope Stress ; Membrane Potential
    ISSN: 1097-2765
    E-ISSN: 10974164
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  • 5
    Language: English
    In: Molecular Cell, 10 October 2013, Vol.52(1), pp.4-7
    Description: Three papers in this issue of Molecular Cell report on the structure and functional activity of type III CRISPR-Cas effector complexes, revealing novel and conserved features of the ribonucleoprotein particles that underlie prokaryotic genome defense. The new structures suggest that type I and type III complexes follow the same architectural principles and are most likely descendants of a common ancestor, the differences in RNA and protein sequences and structure of individual components notwithstanding.
    Keywords: Genomics;
    ISSN: 1097-2765
    E-ISSN: 10974164
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  • 6
    Language: English
    In: Molecular Cell, 2011, Vol.41(3), pp.245-246
    Description: Spot42 is a paradigm for small RNAs that fine-tune carbon metabolism. In this issue of Molecular Cell, Beisel and Storz (2011) reveal that this conserved RNA acts through a multioutput feedforward loop to modulate the global dynamics of sugar consumption.
    Keywords: Rna ; Carbon ; Metabolism ; Business Enterprises ; Sugars;
    ISSN: 1097-2765
    E-ISSN: 10974164
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  • 7
    Language: English
    In: Biophysical Journal, 01/2010, Vol.98(3), S1, pp.488a-489a
    ISSN: 00063495
    Source: Elsevier (via CrossRef)
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  • 8
    Language: English
    In: Current Opinion in Microbiology, 2010, Vol.13(1), pp.24-33
    Description: The ubiquitous RNA-binding protein, Hfq, has been shown to be required for the fitness and virulence of an increasing number of bacterial pathogens. Mutants lacking Hfq are often sensitive to host defense mechanisms and highly attenuated in animal models, albeit there is considerable variation in both severity and extent of phenotypes. RNomics and deep sequencing (RNA-seq) approaches discovered the small RNA and mRNA targets of Hfq, and indicated that this protein might impact on the expression of up to 20% of all genes in some organisms, including genes of type 3 secretion systems . Hfq also facilitates post-transcriptional cross-talk between the core and variable genome regions of bacterial pathogens, and might help integrate horizontally acquired virulence genes into existing regulatory networks.
    Keywords: Pathogenic Microorganisms -- Analysis ; Rna -- Analysis;
    ISSN: 1369-5274
    E-ISSN: 18790364
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  • 9
    Language: English
    In: Cell Host & Microbe, 2010, Vol.8(1), pp.116-127
    Description: Bacteria constitute a large and diverse class of infectious agents, causing devastating diseases in humans, animals, and plants. Our understanding of gene expression control, which forms the basis for successful prevention and treatment strategies, has until recently neglected the many roles that regulatory RNAs might have in bacteria. In recent years, several such regulators have been found to facilitate host-microbe interactions and act as key switches between saprophytic and pathogenic lifestyles. This review covers the versatile regulatory RNA mechanisms employed by bacterial pathogens and highlights the dynamic interplay between riboregulation and virulence factor expression.
    Keywords: Pathogenic Microorganisms ; Gene Expression ; Rna;
    ISSN: 1931-3128
    E-ISSN: 19346069
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  • 10
    Language: English
    In: Molecular Cell, 16 September 2011, Vol.43(6), pp.880-891
    Description: Research on the discovery and characterization of small, regulatory RNAs in bacteria has exploded in recent years. These sRNAs act by base pairing with target mRNAs with which they share limited or extended complementarity, or by modulating protein activity, in some cases by mimicking other nucleic acids. Mechanistic insights into how sRNAs bind mRNAs and proteins, how they compete with each other, and how they interface with ribonucleases are active areas of discovery. Current work also has begun to illuminate how sRNAs modulate expression of distinct regulons and key transcription factors, thus integrating sRNA activity into extensive regulatory networks. In addition, the application of RNA deep sequencing has led to reports of hundreds of additional sRNA candidates in a wide swath of bacterial species. Most importantly, recent studies have served to clarify the abundance of remaining questions about how, when, and why sRNA-mediated regulation is of such importance to bacterial lifestyles.
    Keywords: Academic Libraries -- Physiological Aspects ; Protein Binding -- Physiological Aspects ; Rna -- Physiological Aspects ; Proteins -- Physiological Aspects;
    ISSN: 1097-2765
    E-ISSN: 10974164
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