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  • Elsevier (CrossRef)  (144)
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  • 1
    Language: English
    In: Clinical Neurology and Neurosurgery, 2010, Vol.112(3), pp.252-257
    Description: The authors discuss a rare case of hemorrhage in a filum terminale ependymoma presenting with acute paraparesis and transient hydrocephalic dementia in association with long-term phenprocoumon anticoagulation. The CT scan of the brain revealed the presence of blood in both occipital horns and communicating hydrocephalus. The symptoms gradually resolved after tumor removal and there was no need for shunting. This is a complex clinical presentation of a spinal cord tumor associated hemorrhage, which further illustrates the possibility of retrograde passage of blood from the lumbosacral region to the ventricles.
    Keywords: Intraventricular Hemorrhage ; Hydrocephalus ; Filum Terminale Ependymoma ; Oral Anticoagulation ; Hemorrhagic Spinal Cord Tumor ; Medicine
    ISSN: 0303-8467
    E-ISSN: 1872-6968
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  • 2
    Language: English
    In: International Journal of Surgery, September 2016, Vol.33, pp.72-77
    Description: Based upon our excellent previous experience with 151 adult patients and 39 children whom had the peritoneal catheter in ventriculoperitoneal shunting placed laparoscopically, we continued following this technique as a first-line-procedure in ventriculoperitoneal shunting. Now we analyzed our experience with additional 405 cases for a better comprehension of the complications, advantages and disadvantages of this procedure on this high number of patients. A strict interdisciplinary setting with the maximum of medical intraoperative competence was our goal and therefore better results. N = 405 patients with intraperitoneal shunt insertion from the years 2006–2013 (Follow-up period ranges from 2 to 9 years with a 5,9-year mean follow-up period) were retrospectively analyzed with a special focus on the possible peritoneal catheter complications after laparoscopical shunt insertion. In our department all the peritoneal catheters in ventriculoperitoneal shunting are inserted laparoscopically, when there is no contraindication for this technique. We had 0% peritoneal catheter misplacement rate with help of the laparoscopic technique. In two cases (0.49%) injury of the small bowel could be repaired immediately with no further action required. In two cases umbilical hernias have been accidently discovered and the repair of the hernias took place in the same surgical session. As this technique helps us to control the shunt position intraperitoneally by direct laparoscopic vision, the patients spared an extra radiation exposure, to control the position of the peritoneal catheter. A diagnostic laparoscopy is also possible if needed. The time of the operation is shortened in comparison with the needed time, which is mentioned in literature, for the open laparotomy and of course the needed anesthesia and its possible risks and complications decreased. No revision surgeries were required because of any misplacement of the peritoneal catheter, no additional technique related risks compared to the open surgical technique, no abdominal x-rays were needed, the operation time is shortened and the dose of anesthesia needed is decreased and of course its possible side effects' rate is also decreased. Another great benefit of this technique is the possibility of accidental diagnosis of intra-abdominal pathologies. Also, if a surgical treatment of this accidentally discovered intra-abdominal pathologies is needed, it can take place in the same surgical session. No prolonged surgery time as the laparoscopic technique is much easier, controllable and fast.
    Keywords: Hydrocephalus ; Ventriculoperitoneal Shunt ; Laparoscopy ; Peritoneal Catheter ; Complications
    ISSN: 1743-9191
    E-ISSN: 1743-9159
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  • 3
    Language: English
    In: Clinical Neurology and Neurosurgery, April 2015, Vol.131, pp.64-68
    Description: There is a number of different methods to localize a glioma intraoperatively. Neuronavigation, intraoperative MRI, 5-aminolevulinic acid, as well as intraoperative sonography. Every method has its advantages and disadvantages. Low grade gliomas do not show a specific signal with 5-aminolevulinic acid and are difficult to distinguish macroscopically from normal tissue. In the present study we stress out the importance of intraoperative diagnostic ultrasound for localization of low grade gliomas. We retrospectively evaluated the charts and MRIs of 34 patients with low grade gliomas operated in our department from 2011 until December 2014. The efficacy of ultrasound as an intraoperative navigational tool was assessed. In 15 patients ultrasound was used and in 19 not. Only histologically proven low grades gliomas (astrocytomas grade II) were evaluated. In none of the patients where ultrasound (combined with neuronavigation) was used ( = 15) to find the tumors, the target was missed, whereas the exclusive use of neuronavigation missed the target in 5 of 19 cases of small subcortical low grade gliomas. Intraoperative ultrasound is an excellent tool in localizing low grade gliomas intraoperatively. It is an inexpensive, real time neuronavigational tool, which overcomes brain shift. Even when identifying the tumors with ultrasound is very reliable, the extend of resection and the decision to remove any residual tumor with the help of ultrasound is at the moment unreliable.
    Keywords: Intraoperative Sonography ; Low Grade Glioma ; Neuronavigation ; Medicine
    ISSN: 0303-8467
    E-ISSN: 1872-6968
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  • 4
    Language: English
    In: Journal of Catalysis, 2011, Vol.277(2), pp.196-207
    Description: The catalytic performance of VZrON and novel P-containing VZrPON oxynitrides is compared in the ammoxidation of 3-picoline. Due to higher VO dispersion, lower V valence state and a pronounced formation of P N instead of V N bonds VZrPON catalysts are less active but slightly more selective. ► P incorporation raises V dispersion, forms P N and suppresses V N moieties. ► P lowers activity and improves selectivity only slightly. ► 3-CP selectivity rises with rising N surface concentration. ► Impact of N surface sites on selectivity dominates over surface acidity. Novel P-containing oxynitrides VZrPON were tested besides their VZrPO oxide precursors in the ammoxidation of 3-picoline and compared with P-free VZrON catalysts for analysing the influence of both incorporated P and N on the catalytic performance. Results of XRD, XPS, P and V MAS NMR as well as of simultaneous in situ-EPR/UV–vis/Raman studies during nitridation have shown that the incorporation of phosphorus enhances the V dispersion, reduces vanadium partially even down to V and leads to the formation of a crystalline ZrV P O phase for Zr/V ⩾ 0.5 with V sites surrounded by four O atoms only. N is preferentially incorporated in the vicinity of P, thus, suppressing the formation of V N moieties. These facts may be a reason why the incorporation of P does not markedly improve the catalytic performance of VZrPON catalysts.
    Keywords: Vanadium Zirconium Phosphorus Oxynitrides ; In Situ-Epr/Uv–Vis/Raman Spectroscopy ; Ammoxidation ; 3-Picoline ; Engineering ; Chemistry
    ISSN: 0021-9517
    E-ISSN: 1090-2694
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  • 5
    Language: English
    In: Immunobiology, 2011, Vol.216(3), pp.334-342
    Description: Posttrauma apoptosis resistance of neutrophils (PMN) is related to overshooting immune responses, systemic inflammatory response syndrome (SIRS) and multiple organ failure (MOF). Recently, we have shown that the apoptosis resistance in circulating PMN from severely injured patients which is known to be mediated by high serum levels of pro-inflammatory cytokines can be overcome by the activation of Fas death receptor. Here, we aimed to study whether stimulation of surface Fas leads to the inactivation of hyperactivated PMN from critically ill patients with SIRS. PMN from 23 multiple trauma patients (mean injury severity score (ISS) 34 ± 1.9) were isolated at day 1 after admission to the trauma center. PMN from 17 volunteer blood donors served as controls. Neutrophil activity has been determined after short (1 h) and long-term (4 h) stimulation of freshly isolated PMN with immobilized agonistic anti-Fas antibodies. We found neutrophil chemotactic migration in response to IL-8, phagocytosis and oxidative burst to be significantly inhibited in control cells already after short-term (1 h) Fas stimulation. In contrast, inactivation of trauma PMN by agonistic anti-Fas antibodies was found to be efficient only after long-term (4 h) incubation of cells with agonistic antibodies. Thus, in trauma PMN down-regulation of neutrophil activity seems to be delayed when compared to cells isolated from healthy controls, suggesting impaired susceptibility for Fas stimulation in these cells. Interestingly, whereas Fas-mediated inhibition of phagocytosis and oxidative burst could be prevented by the broad range caspase inhibitor t-butoxycarbonyl-aspartyl(O-methyl)-fluoromethyl ketone (BocD-fmk), the chemotactic activity in response to IL-8 was unaffected. In conclusion, we demonstrate that stimulation of neutrophil Fas does not only initiate apoptosis but also induces inhibition of neutrophil functions, partially by non-apoptotic signaling.
    Keywords: Caspases ; Chemotaxis ; Neutrophils ; Oxidative Burst ; Phagocytosis ; Sirs ; Biology
    ISSN: 0171-2985
    E-ISSN: 1878-3279
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  • 6
    Language: English
    In: Vaccine, 17 April 2014, Vol.32(19), pp.2231-2240
    Description: Currently, the need for cooled storage and the impossibility of terminal sterilisation are major drawbacks in vaccine manufacturing and distribution. To overcome current restrictions a preclinical safety and efficacy study was conducted to evaluate new influenza A vaccine formulations regarding thermal resistance, resistance against irradiation-mediated damage and storage stability. We evaluated the efficacy of novel antigen stabilizing and protecting solutions (SPS) to protect influenza A(H1N1)pdm09 split virus antigen under experimental conditions and . Original or SPS re-buffered vaccine (Pandemrix) was spray-dried and terminally sterilised by irradiation with 25 kGy (e-beam). Antigen integrity was monitored by SDS-PAGE, dynamic light scattering, size exclusion chromatography and functional haemagglutination assays. screening experiments revealed a number of highly stable compositions containing glycyrrhizinic acid (GA) and/or chitosan. The most stable composition was selected for storage tests and assessment of seroconversion in non-human primates (Macaca fascicularis) using a prime-boost strategy. Redispersed formulations with original adjuvant were administered intramuscularly. Storage data revealed high stability of protected vaccines at 4 °C and 25 °C, 60% relative humidity, for at least three months. Animals receiving original Pandemrix exhibited expected levels of seroconversion after 21 days (prime) and 48 days (boost) as assessed by haemagglutination inhibition and microneutralisation assays. Animals vaccinated with spray-dried and irradiated Pandemrix failed to exhibit seroconversion after 21 days whereas spray-dried and irradiated, SPS-protected vaccines elicited similar seroconversion levels to those vaccinated with original Pandemrix. Boost immunisation with SPS-protected vaccine resulted in a strong increase in seroconversion but had only minor effects in animals treated with non SPS-protected vaccine. In conclusion, utilising the SPS formulation technology, spray-drying and terminal sterilisation of influenza A(H1N1)pdm09 split virus vaccine is feasible. Findings indicate the potential utility of such formulated vaccines e.g. for needle-free vaccination routes and delivery to countries with uncertain cold chain facilities.
    Keywords: Thermal Stability ; Viruses ; Irradiation ; Excipients ; Stabilising and Protecting Solution (Sps) ; Dry Powder Vaccine ; Medicine ; Biology ; Veterinary Medicine ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0264-410X
    E-ISSN: 1873-2518
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  • 7
    Language: English
    In: European Journal of Pharmacology, 2010, Vol.645(1), pp.39-46
    Description: Using animal models, volatile anesthetics have been recognized for their neuroprotective effects. Nevertheless, there is still disagreement about the optimal duration and timing of conditioning with the volatile anesthetic sevoflurane in the human system. In the study presented, we employed a human neuronal cell culture model to investigate the effects of hypoxia and to evaluate potential cytoprotective properties of different sevoflurane conditioning strategies. Sevoflurane was applied to human IMR-32 cells in which hypoxic conditions were induced for 2 h using our recently described two-enzyme model (Zitta et al., Eur. J. Pharmacol., 2010). Cellular effects of hypoxia and sevoflurane conditioning were evaluated by lactate dehydrogenase (LDH) measurements, brightfield microscopy, ELISAs, cytometric bead arrays, Westernblotting and RT-PCR. Hypoxia increased the release of LDH into the culture medium after 24 h (normoxia: 0.15 ± 0.02 a.u; hypoxia: 0.69 ± 0.08 a.u, P 〈 0.001) and expression of hypoxia associated genes HIF-1alpha, VEGF, catalase. Cytoprotective effects were observed in cultures that received sevoflurane for 30 min before hypoxia (preconditioning: 0.41 ± 0.07 a.u., P 〈 0.01) and for 30 min during the hypoxic period (intraconditioning: 0.20 ± 0.01 a.u., P 〈 0.001). Application of sevoflurane after the hypoxic insult did not lead to cytoprotection (postconditioning: 0.73 ± 0.12 a.u., P 〉 0.05). Conditioning with sevoflurane for a total of 3 h before, during and after hypoxia, however, resulted in an enhanced release of LDH (periconditioning: 0.97 ± 0.10 a.u., P 〈 0.01) and additional cell damage. Hypoxia and sevoflurane intraconditioning were associated with changes in erk1/2 phosphorylation (T202/Y204) and HIF-1alpha protein levels, whereas phosphorylation of akt (S473) was not significantly altered. Our results suggest short pre- and intraconditioning with sevoflurane as most potent strategies to reduce hypoxia induced neuronal cell damage.
    Keywords: Hypoxia ; Pharmacological Conditioning ; Volatile Anesthetic ; Sevoflurane ; Cell Culture ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0014-2999
    E-ISSN: 1879-0712
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  • 8
    Language: English
    In: Phytochemistry, 2009, Vol.70(4), pp.517-522
    Description: plants growing in hydroponic systems produce increased amounts of kalopanaxsaponin I upon treatment with methyl jasmonate. To further address this observation on molecular level we cloned and functionally characterized the gene ( ), which encodes one of the key enzymes of triterpene saponin biosynthesis. Hydroponically cultivated L. plants treated with methyl jasmonate (MeJA) showed a twelve-fold increase in levels of the monodesmosidic triterpene saponins α-hederin and kalopanaxsaponin I (KsI) in the leaves. We will demonstrate that these two saponins accounted for approximately 10% of the dry plant matter, of which 93% was KsI and 7% α-hederin. To address the molecular basis of saponin induction by MeJA, we cloned and characterized the gene ( ) encoding one of the key enzymes in triterpene saponin biosynthesis. As expected, transcription was induced by MeJA and led to the production of β-amyrin when over-expressed in yeast.
    Keywords: Nigella Sativa ; Ranunculaceae ; Hydroponics ; Methyl Jasmonate ; Saponin ; Hederins ; Kalopanaxsaponin I ; Β-Amyrin Synthase ; Botany
    ISSN: 0031-9422
    E-ISSN: 1873-3700
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  • 9
    Language: English
    In: Materials Today, September 2012, Vol.15(9), pp.394-404
    Description: The demand to develop convergent technology platforms, such as bio-functionalized medical devices, is rapidly increasing. However, the loss of biological function of the effector molecules during sterilization represents a significant and general problem. Therefore, we have developed and characterized a nano-coating (NC) formulation capable of maintaining the functionality of proteins on biological-device combination products. As a proof of concept, the NC preserved the structural and functional integrity of an otherwise highly fragile antibody immobilized on polyurethane during deleterious sterilizing irradiation (≥ 25 kGy). The NC procedure enables straight-forward terminal sterilization of bio-functionalized materials while preserving optimal conditioning of the bioactive surface.
    Keywords: Engineering
    ISSN: 1369-7021
    E-ISSN: 1873-4103
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  • 10
    Language: English
    In: Computer Communications, 1998, Vol.21(12), pp.1080-1089
    Description: Despite the increased bandwidth and the Quality of Service (QoS) capabilities of ATM networks, measurements show that only a fraction of the available bandwidth can be used by applications with current approaches for realizing data communications over ATM employing the TCP/IP protocol suite [1, 2] . This is largely due to the unsuited protocol mechanisms and the lack of QoS support on transport level. Native Mode ATM offers full access to ATM's Quality of Service capabilities in homogenous ATM networks and provides support for a wide range of information streams with different properties and requirements [6] . In order to exploit the capabilities of ATM networks, and to optimally use the available resources, in the network and end system, new transport protocols are inevitable. In this paper we propose the transport protocols ADTS (ATM Data Transfer Service), which uses efficient protocol mechanisms suitable for ATM systems with a minimum of protocol processing overhead. We discuss implementation issues and present performance results obtained with a reference implementation of the ADTS protocol.
    Keywords: Quality of Service ; Atm Networks ; Tcp/Ip Protocols ; Atm Data Transfer Service ; Engineering
    ISSN: 0140-3664
    E-ISSN: 1873-703X
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