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  • 2008  (2)
  • Health Reference Center Academic (Gale)  (2)
  • 1
    Language: English
    In: Phytomedicine, 2008, Vol.15(1), pp.79-83
    Description: are widely used as traditional medicine in Lebanon for treatment of different infection diseases. In the present study we reported the phytochemical composition analyzed by GC–MS of wood essential oil and cones and leaves ethanol extracts. The main components of wood essential oil were himachalol (22.50%), -himachalene (21.90%), and -himachalene (10.50%). Leaves ethanol extract was characterized by a high content of germacrene (29.40%). The same extract obtained from cones essentially contained -pinene (51.0%) and -myrcene (13.0%). Moreover, we investigated extracts, essential oil, and identified compounds for their antiviral activities against herpes simplex virus type 1 (HSV-1). Cytotoxicity was evaluated by MTT assay in Vero cells. Cones and leaves ethanol extracts exhibited an interesting activity with IC of 0.50 and 0.66 mg/ml, respectively, at non-cytotoxic concentration. A comparable activity was found when essential oil was tested (IC of 0.44 mg/ml).
    Keywords: Cedrus Libani A. Rich ; Antiviral Activity ; Herpes Simplex Virus (Hsv-1) ; Gc–MS Analysis ; Medicine ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0944-7113
    E-ISSN: 1618-095X
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  • 2
    Language: English
    In: Apoptosis, 2008, Vol.13(1), pp.119-131
    Description: Myrtucommulone (MC) is a unique, nonprenylated acylphloroglucinol contained in the leaves of myrtle ( Myrtus communis ). Here, we addressed the potential of MC to induce apoptosis of cancer cells. MC potently induced cell death of different cancer cell lines (EC 50 3–8 μM) with characteristics of apoptosis, visualized by the activation of caspase-3, -8 and -9, cleavage of poly(ADP-ribose)polymerase (PARP), release of nucleosomes into the cytosol, and DNA fragmentation. MC was much less cytotoxic for non-transformed human peripheral blood mononuclear cells (PBMC) or foreskin fibroblasts (EC 50 cell death = 20–50 μM), and MC up to 30 μM hardly caused processing of PARP, caspase-3, -8 and -9 in human PBMC. MC-induced apoptosis was mediated by the intrinsic rather than the extrinsic death pathway. Thus, MC caused loss of the mitochondrial membrane potential in MM6 cells and evoked release of cytochrome c from mitochondria. Interestingly, Jurkat cells deficient in caspase-9 were resistant to MC-induced cell death and no processing of PARP or caspase-8 was evident. In cell lines deficient in either CD95 (Fas, APO-1) signalling, FADD or caspase-8, MC was still able to potently induce cell death and PARP cleavage. Conclusively, MC induces apoptosis in cancer cell lines, with marginal cytotoxicity for non-transformed cells, via the mitochondrial cytochrome c/Apaf-1/caspase-9 pathway.
    Keywords: Cancer ; Apoptosis ; Mitochondria ; Caspase ; Myrtucommulone
    ISSN: 1360-8185
    E-ISSN: 1573-675X
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