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  • J-STAGE (Japan Science and Technology Agency)  (99)
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  • 1
    Language: Japanese
    In: 日本臨床細胞学会雑誌, 2014, Vol.53(5), pp.356-361
    Description: 〈b〉目的〈/b〉 : 甲状腺細胞診検査における偽陰性率を低減させることを目的として血中 TSH 値について検討した.〈br〉〈b〉方法〈/b〉 : 甲状腺穿刺細胞診検査が施行され, その後甲状腺切除術および病理組織検査が行われた 276 例を対象として, 術前の血中 TSH 値と病理診断との関係について総計学的に解析した.〈br〉〈b〉成績〈/b〉 : 病理診断が良性の 156 例と悪性の 120 例の間で TSH の平均値に有意差を認めた (p=0.011, t 検定). TSH 1.8μIU/m〈i〉l〈/i〉 以上の 79 例では 1.8 未満の 197 例に比べ有意に悪性が多く (p〈0.001, χ〈sup〉2〈/sup〉検定), オッズ比は 5.06 倍であった. 術前の細胞診検査が陰性であった 170 例においても, TSH 1.8 以上の 30 例では 1.8 未満の 140 例に比べ有意に悪性が多く (p=0.020, χ〈sup〉2〈/sup〉検定), オッズ比は 3.25 倍であった. 細胞診検査が陰性であった 170 例に対して TSH 1.8 以上を悪性の疑いと判定することにより偽陰性例は 19 例から 12 例に減少した.〈br〉〈b〉結論〈/b〉 : 細胞診検査が陰性の症例においても, TSH 1.8 以上は悪性を疑う所見として再検査や外科手術を促すことが細胞診検査の偽陰性率を低下させる有効な手段である.
    Description: 〈b〉〈i〉Objectives〈/i〉〈/b〉 : The serum levels of thyroid stimulating hormone (TSH) were investigated in relation to thyroid malignancy, in order to lower the false-negative rate in thyroid fine-needle aspiration cytology.〈br〉〈b〉〈i〉Study Design〈/i〉〈/b〉 : The preoperative serum TSH levels of 276 thyroid patients were tested. All patients had fine-needle aspiration cytology, then underwent surgical treatments, the histological diagnoses were confirmed, and the significance of the TSH levels was statistically investigated.〈br〉〈b〉〈i〉Results〈/i〉〈/b〉 : TSH levels were significantly different between benign and malignant thyroid diseases (p=0.011, t test). Thyroid cancers were more frequent in those with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 compared to those with TSH levels less than 1.8μIU/m〈i〉l〈/i〉 (p〈0.001, χ〈sup〉2〈/sup〉 test). The odds ratio was 5.06. Furthermore, even in 170 patients with a negative diagnosis based on the cytology, thyroid cancers were more frequent also in those with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 (p=0.020, χ〈sup〉2〈/sup〉 test), and the odds ratio was 3.25. By combining the serum TSH test for 170 patients with negative cytology diagnosis, false-negative cases were reduced to 12 cases from 19 cases.〈br〉〈b〉〈i〉Conclusion〈/i〉〈/b〉 : Even if the result of cytology examinations are negative, patients with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 have a higher risk of malignancy, and should be further examined or surgically treated. This may result in fewer false-negative cases in thyroid cytology.
    Keywords: Thyroid Cancer ; Fine-Needle Aspiration Cytology (Fna) ; Tsh ; False-Negative
    ISSN: 0387-1193
    E-ISSN: 18827233
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  • 2
    Language: Japanese
    In: 理学療法科学, 1996, Vol.11(1), pp.7-10
    Description: この研究の目的は脳卒中片麻痺患者の歩行パターン(前型・揃い型・後型)に関節モーメントが及ぼす影響を検討することである。被験者は歩行に介助を要しない17名の脳卒中片麻痺患者とした。それぞれの被験者について関節モーメントと歩行パターンを測定し,その関連性について検討した。その結果,足接地直後の股関節伸展モーメントと歩行パターンの間に高い相関関係を認めた。この事から揃い型や後型のような歩行パターンは足接地直後の股関節伸展モーメントの低下によって出現すると考える。
    Description: The primary purpose of this study was to examine the relationship between lower limb joint moment and gait patterns of hemiplegic patients after stroke. Subjects consisted of 17 hemiplegic patients after stroke, all those need no assistance in independent gait. Their patterns of gait were classified into three types according to the relative positions between affected and unaffected feet in stepping unaffected heel on the floor; forward, even, and backward. The gait pattern was found highly correlated to the joint moment of hip extension immediately after stepping on the floor. This suggests that abnormal gait patterns such as even or backward may be induced by a decrease in the joint moment of hip extension just after stepping on the floor.
    Keywords: 脳卒中片麻痺 ; 歩行パターン ; 伸展モーメント ; Hemiplegia After Stroke ; Gait Pattern ; Extension Moment
    ISSN: 1341-1667
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  • 3
    Language: Japanese
    In: 日本内分泌・甲状腺外科学会雑誌, 2014, Vol.31(2), pp.108-114
    Description: 甲状腺外科学会病理小委員会では甲状腺細胞診の報告様式を現在の甲状腺癌取扱い規約の様式から甲状腺細胞診ベセスダシステムへ移行することを検討中である。本稿では,取扱い規約とベセスダシステムの報告様式の違いを紹介すると共に,自験例の診断成績を用いて甲状腺細胞診ベセスダシステムの妥当性について検討した。取扱い規約とベセスダシステムの主な違いは,①細胞学的に鑑別困難な症例を,濾胞性腫瘍を疑う群(FN/SFN)とそうでない群(AUS/FLUS)の2つの診断カテゴリーに分けた点,②不適正の判定基準を明確にした点,③各診断カテゴリーについて悪性の危険度を数値で示した点の3点である。両者の基本的な考え方は類似しているので,大きな混乱なくベセスダシステムへの移行が可能と考えている。
    Keywords: 甲状腺癌 ; 穿刺吸引細胞診 ; 報告様式 ; 甲状腺癌取扱い規約 ; 甲状腺ベセスダシステム ; Thyroid Cancer ; Fine-Needle Aspiration Cytology ; Reporting System ; Japanese General Rules For Thyroid Cancer ; Bethesda System For Thyroid Cancer
    ISSN: 2186-9545
    ISSN: 03871193
    E-ISSN: 18827233
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  • 4
    Language: English
    In: Chemical and Pharmaceutical Bulletin, 1998, Vol.46(4), pp.733-735
    Description: Synthesis of (2S, 3S)-3-amino-2-hydroxy-4-phenylbutyric acid was achieved by the highly diastereoselective cyanohydrin formation of (S)-2-N, N-dibenzylamino-3-phenylpropanal with acetone cyanohydrin in the presence of trimethyl-aluminum as a key step.
    Keywords: Kni-227 ; Hiv Protease Inhibitor ; 3-Amino-2-Hydroxy-4-Phenylbutyric Acid ; Acetone Cyanohydrin ; Diastereoselective Reaction
    ISSN: 0009-2363
    E-ISSN: 13475223
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  • 5
    Language: Japanese
    In: 日本消化器病学会雑誌, 2014, Vol.111(2), pp.288-295
    Description: 症例は82歳女性.20年来の気管支拡張症の加療歴あり.食欲不振,下痢のため入院.S状結腸鏡で多発する発赤とびらんを認め,病理所見から続発性/反応性AAアミロイドーシスと診断された.上部消化管内視鏡では食道に暗褐色調粘膜を認め,急性壊死性食道炎と診断した.また,胃に多発するびらん,十二指腸に広範な地図状びらんを認めた.アミロイドーシスの急性壊死性食道炎合併例は既報がなく,極めてまれと考えられた.〈br〉
    Description: An 82-year-old woman with a history of bronchiectasis for 20 years was admitted to our hospital with anorexia and diarrhea. Sigmoidoscopy showed multiple mucosal erythematous areas and erosions. Histologic examination with Congo red stain revealed massive amyloid deposition around the submucosal vessels as well as in the parenchyma of the mucosa and submucosa. With immunohistochemistry, the diagnosis of secondary/reactive AA amyloidosis was confirmed. Esophagogastroduodenoscopy demonstrated diffuse dark brown mucosa, establishing the diagnosis of acute necrotizing esophagitis. Ischemia associated with amyloid deposition of the vessels in the esophagus was considered to be a possible etiology of acute necrotizing esophagitis. Additionally, gastric outlet obstruction and gastroesophageal reflux associated with gastroduodenal erosions caused by amyloid deposition were supposed to be another factor. Amyloid deposition in the esophageal mucosa may cause a reduction in mucosal defense that is responsible for the pathogenesis. We report the first case of acute necrotizing esophagitis associated with amyloidosis.〈br〉
    Keywords: アミロイドーシス ; 気管支拡張症 ; 急性壊死性食道炎
    ISSN: 0446-6586
    Source: Japan Science and Technology Agency
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  • 6
    Language: Japanese
    In: 理学療法科学, 2003, Vol.18(3), pp.131-134
    Description: ここでは脳卒中片麻痺患者の歩行時の関節モーメントに着目し,片麻痺歩行の力学的特長,関節モーメント低下の原因,臨床応用などについて検討した。〈br〉
    Description: Paying our attention to joint moment during gait of hemiplegic patients after stroke, we examined mechanical characteristics of hemiplegic gait, causes for decrease in joint moment and clinical applicability of our results.〈br〉
    Keywords: 脳卒中片麻痺 ; 歩行 ; 関節モーメント ; Hemiplegia After Stroke ; Gait ; Joint Moment
    ISSN: 1341-1667
    Source: Japan Science and Technology Agency
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  • 7
    Language: Japanese
    In: 理学療法科学, 1995, Vol.10(1), pp.45-48
    Description: 健常人10名に対し,6段階の高さに設定した手すりを用いて椅子からの立ち上がり動作を行い,その時の股関節,膝関節,足関節の各モーメントを測定した。手すりの高さと各モーメントのピークの関係を検討したところ,膝関節,足関節に関しては有意な差は認められなかった。股関節のピークモーメントにおいては,手すりの高さの変化に対して3つのパターンが認められた。これは手すりの使い方がいくつかのパターンとして股関節に反映されたものと思われる。
    Description: Ten healthy adult subjects performed standing-up movements from a chair with the aid of handrails of six different heights, and the moments of hip, knee, and ankle joints were measured. There was no significant difference in the peak moments of knee and ankle joints between the 6 handrails. The peak moment of hip joint indicated three patterns according to changes in height of handrails. This is considered to be reflected by different ways to use handrails.
    Keywords: 立ち上がり動作 ; 手すり ; モーメント ; Standing-Up Movement ; Handrail ; Moment
    ISSN: 1341-1667
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  • 8
    Language: Japanese
    In: 日本公衆衛生雑誌, 2002, Vol.49(8), pp.729-738
    Description: 〈b〉目的〈/b〉 冠動脈疾患や 2 型糖尿病の発症予防には,その背景因子である「死の四重奏」(上半身肥満,高血圧,高トリグリセライド血症,耐糖能低下)やインスリン抵抗性の関与が推測されているマルチプルリスクファクター症候群の予防を目的とした危険因子の改善が重要である。都市部の地域において HbA1c 値と動脈硬化危険因子との関連性について報告がみられないことから神奈川県 2 市で検討を行い,さらに地域における集団の違いがこれらの関連に与える影響を分析した。〈br/〉〈b〉方法〈/b〉 平成10年度に基本健康診査で全受診者に HbA1c 値を測定していた神奈川県中央部の隣接する 2 市の40歳から79歳までの男女を対象とした。HbA1c 値の関連因子として年齢,Body Mass Index(BMI),収縮期血圧値(SBP 値),拡張期血圧値(DBP 値),血清総コレステロール値(TC 値),HDL コレステロール値(HDL-C 値),血清トリグリセライド値(TG 値),GOT 値,GPT 値,尿酸値,γGTP 値を取り上げ,これらの因子と HbA1c 値との間の相関係数を求めた。次に HbA1c 値との間で有意な相関関係が得られた因子と 2 市を区別する変数を独立変数に,HbA1c 値の指導区分で要指導以上かそうでないかを従属変数としてロジスティック回帰分析を行った。地域の違いが各因子の HbA1c 値への関連に影響を与えるか交互作用項を追加して分析した。〈br/〉〈b〉結果〈/b〉 1. 男性において,両地域に共通して年齢,BMI, TC 値,γGTP 値について HbA1c 値との間で有意な正の関連が,尿酸値に有意な負の関連が認められた。〈br/〉 2. 女性において交互作用項を含むモデルでロジスティック回帰分析を行った場合,両地域に共通して年齢,BMI, SBP 値,TC 値,TG 値,GPT 値,γGTP 値について HbA1c 値との間に有意な正の関連を,GOT 値について有意な負の関連を認めた。TC 値については交互作用項が有意なことから HbA1c 値との関連の程度が地域集団の違いにより異なると考えられた。〈br/〉〈b〉結論〈/b〉 男性で HbA1c 値に対する正の関連因子として認められた TC 値,女性での BMI, TC 値についてはこれまでの本邦の報告と一致し,女性に認められた TG 値は欧米での報告と一致していた。男性での γGTP 値,女性での GPT 値,γGTP 値については HbA1c 値に対する正の関連因子として今回の検討で初めて認められた。HbA1c 値が従来から言われてきた肥満だけでなく脂質代謝,肝機能検査値,血圧の複数因子との関連が認められたことから,地域住民の HbA1c 値と動脈硬化危険因子との関連を検討することは住民の複数危険因子の評価に有用と考えられた。
    Description: 〈b〉Purpose〈/b〉 To prevent coronary heart disease and type 2 diabetes mellitus, we need to focus on “the deadly quartet” (coexistence of upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertention), and the multiple risk factor syndrome related to insulin resistance. As few urban community-based population studies have evaluated the correlation between glycated hemoglobin A1c (HbA1c) levels and risks of life-style related disease, we investigated this parameter and its correlation with atherosclerotic risk factors in participants of health check ups in two communities in Kanagawa prefecture. We also examined whether these correlations were affected by difference between the two groups.〈br/〉〈b〉Methods〈/b〉 The study populations comprised male and female residents aged 40-79 in two communities (A and B cities) in 1998.〈br/〉Age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), HDL-cholesterol (HDL-C), triglycerides (TG), GOT, GPT, Uric acid (UA), and γGTP were considered as atherosclerotic risk factors. Firstly we calculated correlation coefficients with HbA1c level. Secondly, logistic regression analyses were performed with HbA1c as the dependent variable, and risk factors correlated with HbA1c significantly and variable for each community as independent variables. To assess whether community differences affect associations between HbA1c levels and risk factors, we added interaction terms as independent variables in the logistic regression analysis.〈br/〉〈b〉Results〈/b〉 1. There were no significant interaction terms while significant positive associations were observed between HbA1c and age, BMI, and levels of TC and γGTP for men in both communities. A significant negative association was observed between HbA1c and UA..〈br/〉 2. Age, BMI, and the levels of SBP, TG, GPT, and γGTP were positively associated, and GOT was negatively associated with the HbA1c levels in women in both communities. Each community had its own association between TC and HbA1c.〈br/〉〈b〉Conclusions〈/b〉 The findings that TC is associated with HbA1c in men, and that BMI and the level of TC are linked with HbA1c in women are consistent with previous results for Japanese. The association between HbA1c and TG in women was newly observed for Japanese. Furthermore, the levels of γGTP in both sexes and also GPT in women are associated with HbA1c. From these results, investigating linkage between HbA1c level and atherosclerotic risk factors was thought to be appropriate for estimating accumulation of multiple risk factors in the community.
    Keywords: HbA1c 値 ; マルチプルリスクファクター症候群 ; 基本健康診査 ; 動脈硬化危険因子 ; Hba1c ; Health Checkup ; Multiple Risk Factor Syndrome ; Atherosclerotic Risk Factors
    ISSN: 0546-1766
    E-ISSN: 21878986
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  • 9
    Language: Japanese
    In: 日本食生活学会誌, 2018, Vol.29(2), pp.111-118
    Description: 〈p〉 When people share big plates of food, from which everyone takes as much as he/she wants to eat, the last portion on the plate is often left untouched due to everyone’s hesitation. This study observed eating behavior in 21 groups; each group had three people sharing five big plates of food. In total, 11 groups, with all members familiar with each other (friend condition), and 10 groups, with all members unfamiliar with each other (stranger condition), participated in the study. In each group, the members were all of the same gender and, with the exception of one group, all were of the same age. By comparing these two conditions, this study aimed to examine whether people change their serving behavior depending on their relationship with the people they are sharing the food with. It was shown that in both the conditions, people stopped helping themselves to certain foods, that is, fried chicken and fried rice, at the final stage of the meal. The total amount of food eaten by each individual was less equal in the friend condition than in the stranger one. Deciding who would eat the remaining food by "janken” was only observed in the friend condition. These results suggested that when people share food with strangers, food is more equally distributed amongst the members compared to when people share it with friends.〈/p〉
    Keywords: 共食 ; 共食い ; 行動 ; 場面 ; 対面 ; 友人 ; 友達 ; 料理;
    ISSN: 1346-9770
    E-ISSN: 18812368
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  • 10
    Language: English
    In: Quarterly Report of RTRI, 2016, Vol.57(1), pp.29-35
    Description: This study aims to develop a model of passenger behavior when choosing trains from among various types of train service such as local and rapid services in urban railways, in order to evaluate passenger flows. This paper describes an online survey method for obtaining passenger activity data using departure information display images. A disaggregate demand model was developed for train choice behavior based on the survey data which were collected using the method. The developed model is put into practice by means of an application named "Train-Choice Model Viewer", which can calculate the time series data of passengers' volume at stations and in trains. It makes it possible to simulate the congestion level on each train and in each station when the time schedule is input.
    Keywords: Train Choice Behavior ; Urban Railways ; Passengers&Amp;#X27; Flow ; Departure Information Displays
    ISSN: 0033-9008
    E-ISSN: 18801765
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