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Berlin Brandenburg

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  • JSTOR Archival Journals  (20)
Type of Medium
Language
Year
  • 1
    Language: English
    In: Journal of Consumer Research, 1 September 1988, Vol.15(2), pp.243-252
    Description: The cognitive tradeoff between price and product quality is used as a basis for hypothesizing interrelationships between two individual difference variables and two price-related responses. Results of a correlational study support the hypothesis of an inverse relationship between price consciousness and product involvement and the hypotheses that price consciousness and product involvement have opposite implications for several price-related constructs. Results also indicate a positive relationship between price acceptability level and the width of the latitude of price acceptance.
    Keywords: Business -- Business information -- Consumer research -- Shoes ; Business -- Industry -- Industrial sectors -- Shoes ; Economics -- Economic disciplines -- Applied economics -- Shoes ; Business -- Business operations -- Commerce -- Shoes ; Business -- Business administration -- Corporate communications -- Shoes ; Behavioral sciences -- Anthropology -- Ethnology -- Shoes ; Behavioral sciences -- Psychology -- Applied psychology -- Shoes ; Business -- Business operations -- Commerce -- Shoes ; Business -- Business operations -- Commerce -- Shoes ; Mathematics -- Applied mathematics -- Statistics -- Shoes
    ISSN: 00935301
    E-ISSN: 15375277
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  • 2
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 29 October 2013, Vol.110(44), pp.17921-6
    Description: Chromatin-based functional genomic analyses and genomewide association studies (GWASs) together implicate enhancers as critical elements influencing gene expression and risk for common diseases. Here, we performed systematic chromatin and transcriptome profiling in human pancreatic islets. Integrated analysis of islet data with those from nine cell types identified specific and significant enrichment of type 2 diabetes and related quantitative trait GWAS variants in islet enhancers. Our integrated chromatin maps reveal that most enhancers are short (median = 0.8 kb). Each cell type also contains a substantial number of more extended (≥ 3 kb) enhancers. Interestingly, these stretch enhancers are often tissue-specific and overlap locus control regions, suggesting that they are important chromatin regulatory beacons. Indeed, we show that (i) tissue specificity of enhancers and nearby gene expression increase with enhancer length; (ii) neighborhoods containing stretch enhancers are enriched for important cell type-specific genes; and (iii) GWAS variants associated with traits relevant to a particular cell type are more enriched in stretch enhancers compared with short enhancers. Reporter constructs containing stretch enhancer sequences exhibited tissue-specific activity in cell culture experiments and in transgenic mice. These results suggest that stretch enhancers are critical chromatin elements for coordinating cell type-specific regulatory programs and that sequence variation in stretch enhancers affects risk of major common human diseases.
    Keywords: Cell Differentiation -- Physiology ; Chromatin -- Physiology ; Diabetes Mellitus, Type 2 -- Physiopathology ; Enhancer Elements, Genetic -- Genetics ; Epigenomics -- Methods ; Gene Expression Regulation -- Physiology ; Insulin-Secreting Cells -- Metabolism
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 3
    Language: English
    In: Science, 17 April 1987, Vol.236(4799), pp.244-245
    Keywords: Applied sciences -- Engineering -- Aerospace engineering ; Physical sciences -- Astronomy -- Space science ; Applied sciences -- Engineering -- Aerospace engineering ; Physical sciences -- Astronomy -- Space science ; Physical sciences -- Physics -- Fundamental forces ; Physical sciences -- Physics -- Fundamental forces ; Applied sciences -- Engineering -- Aerospace engineering ; Physical sciences -- Astronomy -- Astronomical instrumentation ; Applied sciences -- Engineering -- Aerospace engineering ; Philosophy -- Applied philosophy -- Philosophy of science
    ISSN: 00368075
    E-ISSN: 10959203
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  • 4
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 01 October 1996, Vol.93(20), pp.10876-10880
    Description: Erythropoietin (Epo)-responsive anemia is a common and debilitating complication of chronic renal failure and human immunodeficiency virus infection. Current therapy for this condition involves repeated intravenous or subcutaneous injections of recombinant Epo. In this report, we describe the development of a novel muscle-based gene transfer approach that produces long-term expression of physiologically significant levels of Epo in the systemic circulation of mice. We have constructed a plasmid expression vector, pVRmEpo, that contains the murine Epo cDNA under the transcriptional control of the cytomegalovirus immediate early (CMV-IE) promoter, the CMV-IE 5$^{\prime}$ untranslated region, and intron A. A single intramuscular (i.m.) injection of as little as 10 $\mu $g of this plasmid into immunocompetent adult mice produced physiologically significant elevations in serum Epo levels and increased hematocrits from preinjection levels of 48 $\pm $ 0.4% to levels of 64 $\pm $ 3.3% 45 days after injection. Hematocrits in these animals remained elevated at greater than 60% for at least 90 days after a single i.m. injection of 10 $\mu $g of pVRmEpo. We observed a dose--response relationship between the amount of plasmid DNA injected and subsequent elevations in hematocrits. Mice injected once with 300 $\mu $g of pVRmEpo displayed 5-fold increased serum Epo levels and elevated hematocrits of 79 $\pm $ 3.3% at 45 days after injection. The i.m. injected plasmid DNA remained localized to the site of injection as assayed by the PCR. We conclude that i.m. injection of plasmid DNA represents a viable nonviral gene transfer method for the treatment of acquired and inherited serum protein deficiencies.
    Keywords: Biological sciences -- Biology -- Genetics ; Physical sciences -- Chemistry -- Chemical compounds ; Arts -- Literature -- Literary genres ; Health sciences -- Medical diagnosis -- Diagnostic methods ; Biological sciences -- Biology -- Genetics ; Biological sciences -- Biology -- Zoology ; Physical sciences -- Chemistry -- Chemical compounds ; Biological sciences -- Biology -- Anatomy ; Applied sciences -- Laboratory techniques -- Nucleic acid amplification techniques ; Physical sciences -- Chemistry -- Chemical compounds
    ISSN: 00278424
    E-ISSN: 10916490
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  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 01 October 1996, Vol.93(20), pp.10876-10880
    Description: Erythropoietin (Epo)-responsive anemia is a common and debilitating complication of chronic renal failure and human immunodeficiency virus infection. Current therapy for this condition involves repeated intravenous or subcutaneous injections of recombinant Epo. In this report, we describe the development of a novel muscle-based gene transfer approach that produces long-term expression of physiologically significant levels of Epo in the systemic circulation of mice. We have constructed a plasmid expression vector, pVRmEpo, that contains the murine Epo cDNA under the transcriptional control of the cytomegalovirus immediate early (CMV-IE) promoter, the CMV-IE 5$^{\prime}$ untranslated region, and intron A. A single intramuscular (i.m.) injection of as little as 10 $\mu $g of this plasmid into immunocompetent adult mice produced physiologically significant elevations in serum Epo levels and increased hematocrits from preinjection levels of 48 $\pm $ 0.4% to levels of 64 $\pm $ 3.3% 45 days after injection. Hematocrits in these animals remained elevated at greater than 60% for at least 90 days after a single i.m. injection of 10 $\mu $g of pVRmEpo. We observed a dose--response relationship between the amount of plasmid DNA injected and subsequent elevations in hematocrits. Mice injected once with 300 $\mu $g of pVRmEpo displayed 5-fold increased serum Epo levels and elevated hematocrits of 79 $\pm $ 3.3% at 45 days after injection. The i.m. injected plasmid DNA remained localized to the site of injection as assayed by the PCR. We conclude that i.m. injection of plasmid DNA represents a viable nonviral gene transfer method for the treatment of acquired and inherited serum protein deficiencies.
    Keywords: Sciences (General);
    ISSN: 00278424
    E-ISSN: 10916490
    Source: Archival Journals (JSTOR)
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  • 6
    In: Science, Jan 14, 2000, Vol.287(5451), p.234
    Keywords: Conservation of Natural Resources ; Ecosystem;
    ISSN: 0036-8075
    E-ISSN: 10959203
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  • 7
    Language: English
    In: Science, 27 April 1984, Vol.224(4647), pp.338-340
    Keywords: Health sciences -- Medical sciences -- Nutritional science ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Medical sciences -- Pharmaceutics ; Biological sciences -- Biochemistry -- Biomolecules ; Behavioral sciences -- Human behavior -- Recreational drug use ; Biological sciences -- Biology -- Zoology ; Applied sciences -- Food science -- Foodstuffs ; Health sciences -- Health and wellness -- Public health ; Health sciences -- Medical conditions -- Diseases ; Philosophy -- Applied philosophy -- Philosophy of science
    ISSN: 00368075
    E-ISSN: 10959203
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  • 8
    Language: English
    In: Science, 21 August 1964, Vol.145(3634), pp.809-811
    Description: Isolated teeth of multituberculates have been found in association with late Eocene fossil mammals. Previous studies reported that multituberculates were not found in deposits younger than early Eocene age (Gray-bull provincial substage or equivalents). This newly found occurrence indicates that these animals are more likely to be late Eocene in age than reworked early Eocene materials.
    ISSN: 00368075
    E-ISSN: 10959203
    Source: Archival Journals (JSTOR)
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  • 9
    Language: English
    In: Science, 21 August 1964, Vol.145(3634), pp.809-811
    Description: Isolated teeth of multituberculates have been found in association with late Eocene fossil mammals. Previous studies reported that multituberculates were not found in deposits younger than early Eocene age (Gray-bull provincial substage or equivalents). This newly found occurrence indicates that these animals are more likely to be late Eocene in age than reworked early Eocene materials.
    Keywords: Biological sciences -- Biology -- Zoology ; Applied sciences -- Engineering -- Electrical engineering ; Biological sciences -- Biochemistry -- Biomolecules ; Physical sciences -- Physics -- Fundamental forces ; Biological sciences -- Paleontology -- Paleobiology ; Physical sciences -- Earth sciences -- Geology ; Applied sciences -- Engineering -- Electrical engineering ; Applied sciences -- Engineering -- Electrical engineering ; Physical sciences -- Physics -- Microphysics ; Arts -- Applied arts -- Architecture
    ISSN: 00368075
    E-ISSN: 10959203
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  • 10
    Language: English
    In: Science (New York, N.Y.), 10 December 2010, Vol.330(6010), pp.1503-9
    Description: Using data for 25,780 species categorized on the International Union for Conservation of Nature Red List, we present an assessment of the status of the world's vertebrates. One-fifth of species are classified as Threatened, and we show that this figure is increasing: On average, 52 species of mammals, birds, and amphibians move one category closer to extinction each year. However, this overall pattern conceals the impact of conservation successes, and we show that the rate of deterioration would have been at least one-fifth again as much in the absence of these. Nonetheless, current conservation efforts remain insufficient to offset the main drivers of biodiversity loss in these groups: agricultural expansion, logging, overexploitation, and invasive alien species.
    Keywords: Biodiversity ; Conservation of Natural Resources ; Ecosystem ; Vertebrates
    ISSN: 00368075
    E-ISSN: 1095-9203
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