World Journal of Surgery, 2011, Vol.35(5), pp.1010-1016
BACKGROUNDThe present study was designed to evaluate the impact of the tyrosine kinase ligands VEGF-A/C/D, PDGF-A/B on tumor dissemination and survival in gastric cancer. This is the first study analyzing all these parameters in a homogeneous patient population undergoing surgery. METHODSThe expression pattern of VEGF-A/C/D and PDGF-A/B was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR) in 69 samples of human gastric adenocarcinoma and correlated with tumor stage and survival. RESULTSExpression of the ligand VEGF-D significantly correlated with distant metastatic disease (P=0.00001) but not with patient survival. However, VEGF-A inversely correlated with M1 and grading, PDGF-A inversely correlated with pT and pN category. In contrast, VEGF-C and PDGF-B did not have an impact on clinicopathological parameters. CONCLUSIONSThe ligand VEGF-D, rather than the other ligands or tyrosine kinase receptors analyzed, is associated with progressive disease in gastric cancer patients undergoing surgery. The VEGF-D ligand might be a helpful marker indicating disseminated disease, and targeting VEGF-D may be a potential therapeutic strategy, although limitations imposed by the selected sample population have to be considered critically.
Adenocarcinoma–Mortality ; Adult–Pathology ; Aged–Surgery ; Aged, 80 and Over–Metabolism ; Female–Mortality ; Humans–Pathology ; Immunohistochemistry–Surgery ; Male–Metabolism ; Middle Aged–Metabolism ; Neoplasm Metastasis–Metabolism ; Platelet-Derived Growth Factor–Metabolism ; Reverse Transcriptase Polymerase Chain Reaction–Metabolism ; Stomach Neoplasms–Metabolism ; Vascular Endothelial Growth Factor A–Metabolism ; Vascular Endothelial Growth Factor C–Metabolism ; Vascular Endothelial Growth Factor D–Metabolism ; Platelet-Derived Growth Factor ; Vascular Endothelial Growth Factor A ; Vascular Endothelial Growth Factor C ; Vascular Endothelial Growth Factor D;
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